Abstract
Chromium is a well-known mutagen and carcinogen involved in lung cancer development. DNA repair genes play an important role in the elimination of genetic changes caused by chromium exposure. In the present study, we investigated the polymorphisms of the following DNA repair genes: XRCC3, participating in the homologous recombination repair, and hMLH1 and hMSH2, functioning in the mismatch repair. We focused on the risk the polymorphisms present in the development of lung cancer regarding the exposure to chromium. We analyzed 106 individuals; 45 patients exposed to chromium with diagnosed lung cancer and 61 healthy controls. Genotypes were determined by a PCR-RFLP method. We unravelled a potential for increased risk of lung cancer development in the hMLH1 (rs1800734) AA genotype in the recessive model. In conclusion, gene polymorphisms in the DNA repair genes underscores the risk of lung cancer development in chromium exposed individuals.
Keywords
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Acknowledgements
This work was supported by the Ministry of Health of the Slovak Republic Grants 2012/25-UKMA-2, APVV-0412-11, and VEGA 1/0336/12.
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The authors declare no conflicts of interest in relation to this article.
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Halasova, E. et al. (2016). Polymorphisms of Selected DNA Repair Genes and Lung Cancer in Chromium Exposure. In: Pokorski, M. (eds) Advances in Respiratory Cancerogenesis. Advances in Experimental Medicine and Biology(), vol 911. Springer, Cham. https://doi.org/10.1007/5584_2016_218
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DOI: https://doi.org/10.1007/5584_2016_218
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