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Advances in Respiratory Cancerogenesis

Volume 911 of the series Advances in Experimental Medicine and Biology pp 17-22

Date:

Polymorphisms of Selected DNA Repair Genes and Lung Cancer in Chromium Exposure

  • E. HalasovaAffiliated withDivision of Molecular Medicine, Biomedical Center Martin, Comenius University in BratislavaDepartment of Medical Biology, Comenius University in Bratislava
  • , T. MatakovaAffiliated withDepartment of Medical Biochemistry, Comenius University in Bratislava Email author 
  • , M. SkerenovaAffiliated withDepartment of Clinical Biochemistry, University Hospital Martin
  • , M. KrutakovaAffiliated withDivision of Molecular Medicine, Biomedical Center Martin, Comenius University in Bratislava
  • , P. SlovakovaAffiliated withDivision of Molecular Medicine, Biomedical Center Martin, Comenius University in Bratislava
  • , A. DzianAffiliated withClinic of Thoracic Surgery and University Hospital Martin, Comenius University in Bratislava
  • , S. JavorkovaAffiliated withClinic of Paediatrics, Central Military Hospital
  • , M. PecAffiliated withDepartment of Medical Biology, Comenius University in Bratislava
  • , K. KypusovaAffiliated withDepartment of Medical Biology, Comenius University in Bratislava
    • , J. HamzikAffiliated withClinic of Thoracic Surgery and University Hospital Martin, Comenius University in Bratislava

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Abstract

Chromium is a well-known mutagen and carcinogen involved in lung cancer development. DNA repair genes play an important role in the elimination of genetic changes caused by chromium exposure. In the present study, we investigated the polymorphisms of the following DNA repair genes: XRCC3, participating in the homologous recombination repair, and hMLH1 and hMSH2, functioning in the mismatch repair. We focused on the risk the polymorphisms present in the development of lung cancer regarding the exposure to chromium. We analyzed 106 individuals; 45 patients exposed to chromium with diagnosed lung cancer and 61 healthy controls. Genotypes were determined by a PCR-RFLP method. We unravelled a potential for increased risk of lung cancer development in the hMLH1 (rs1800734) AA genotype in the recessive model. In conclusion, gene polymorphisms in the DNA repair genes underscores the risk of lung cancer development in chromium exposed individuals.

Keywords

Carcinogens Chromium exposure DNA repair Genes Genotype Lung cancer Polymorphism