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Functions of stress-activated MAP kinases in the immune response

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Book cover Stress-Activated Protein Kinases

Part of the book series: Topics in Current Genetics ((TCG,volume 20))

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Abstract

The stress-activated protein kinases (SAPK) represent one group of mitogen-activated protein kinases (MAPKs) that are activated by antigen receptors, Toll-like receptors, cytokine receptors, and physical-chemical changes in the environment. The SAPK are established to be important mediators of intracellular signaling during both adaptive and innate immune responses. Here, we summarize recent findings concerning the role of two sub-groups of SAPK – cJun NH2-terminal kinase (JNK) and p38 MAPK.

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Authors and Affiliations

  1. Immunology Program, Department of Medicine, University of Vermont, 05405, Burlington, VT, USA

    Mercedes Rincón

  2. Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 01605, Worcester, MA, USA

    Roger J. Davis

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  1. Mercedes Rincón
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Correspondence to Mercedes Rincón .

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Francesc Posas Angel R. Nebreda

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Rincón, M., Davis, R.J. (2007). Functions of stress-activated MAP kinases in the immune response. In: Posas, F., Nebreda, A.R. (eds) Stress-Activated Protein Kinases. Topics in Current Genetics, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4735_2007_0253

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