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Stress-Activated Protein Kinases pp 187–204Cite as

Regulation of MAPK Signaling in Yeast

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Part of the book series: Topics in Current Genetics ((TCG,volume 20))

Abstract

Mitogen activated protein kinase (MAPK) pathways orchestrate the response of cells to their changing extracellular environment. Budding yeast has proven to be a useful model system to elucidate the basic principles of these complex signal transduction processes. Yeast cells use six MAP-kinases, which respond to diverse conditions such as pheromone signals, osmolarity, cell wall stress and nutritional status. Depending on the external and internal conditions, multiple signals must be integrated leading to a defined output and different signaling kinetics. In this review, we will discuss the molecular architecture of the mating and high-osmolarity-glycerol (HOG) MAPK pathways, and compare their underlying signaling parameters. These two pathways use shared components and by contrasting their activation and regulation we try to deduce common and specific principles for MAPK signaling in yeast. Among those, we will summarize and discuss recent findings, which shed light on positive and negative feedback mechanisms. Finally, we will highlight the importance of quantitative measurements in single cells, which are necessary to unravel stochastic cell-to-cell variations and account for the dynamic signaling kinetics.

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Author information

Authors and Affiliations

  1. Competence Center for Systems Physiology and Metabolic Disease (CC-SPMD), Institute of Biochemistry, ETH Zürich, 8093, Zürich, Switzerland

    Fabian Rudolf

  2. Institute of Biochemistry, ETH Zürich, 8093, Zürich, Switzerland

    Serge Pelet & Matthias Peter

Authors
  1. Fabian Rudolf
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  2. Serge Pelet
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  3. Matthias Peter
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Correspondence to Matthias Peter .

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Francesc Posas Angel R. Nebreda

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© 2007 Springer-Verlag Berlin Heidelberg

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Rudolf, F., Pelet, S., Peter, M. (2007). Regulation of MAPK Signaling in Yeast. In: Posas, F., Nebreda, A.R. (eds) Stress-Activated Protein Kinases. Topics in Current Genetics, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4735_2007_0250

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