Chapter

Luminescent and Photoactive Transition Metal Complexes as Biomolecular Probes and Cellular Reagents

Volume 165 of the series Structure and Bonding pp 1-45

Date:

Photo-Controlled Release of NO and CO with Inorganic and Organometallic Complexes

  • Agustin E. PierriAffiliated withDepartment of Chemistry and Biochemistry, University of California, Santa Barbara
  • , Dayana A. MuizziAffiliated withDepartment of Chemistry and Center for Photochemical Sciences, Bowling Green State University
  • , Alexis D. OstrowskiAffiliated withDepartment of Chemistry and Center for Photochemical Sciences, Bowling Green State University Email author 
  • , Peter C. FordAffiliated withDepartment of Chemistry and Biochemistry, University of California, Santa Barbara Email author 

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Abstract

The photochemical delivery of bioactive small molecules to physiological targets provides the opportunity to control the location, timing, and dosage of such delivery. We will discuss recent developments of the synthesis and studies of various metal complexes designed for targeted release of the bioregulatory diatomics nitric oxide and carbon monoxide. Of considerable interest are those systems where the NO or CO precursor and/or the photochemical product is luminescent such that imaging techniques allow one to identify the release location.

Keywords

Carbon monoxide Luminescence Near-infrared excitation Nitric oxide PhotoCORM PhotoNORM Photoreaction