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Dioxygen Activation by Biomimetic Iron Complexes of α-Keto Acids and α-Hydroxy Acids

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Book cover Molecular Design in Inorganic Biochemistry

Part of the book series: Structure and Bonding ((STRUCTURE,volume 160))

Abstract

A subset of the large family of nonheme iron oxygenases carries out the oxidative decarboxylation of α-ketocarboxylate and α-hydroxycarboxylate substrates in the presence of O2. Iron complexes of α-ketocarboxylates and α-hydroxycarboxylates supported by tridentate and tetradentate ligands have been synthesized to act as functional models for these enzymes, and several have been structurally characterized. From studies of these model complexes and their reactivity toward various probe substrates, insights into the reaction mechanisms have been obtained, where iron(III)-superoxo and iron(IV)-oxo species have been implicated as key oxidants.

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Acknowledgments

The authors are supported respectively by the DST, Govt. of India (Project: SR/S1/IC-51/2010), and the US National Science Foundation (Grant CHE-1058248). We thank Dr. Caleb Allpress for a careful reading of the final manuscript.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Indian Association for the Cultivation of Science, 2A&2B Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, India

    Tapan Kanti Paine

  2. Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN, 55455, USA

    Lawrence Que Jr.

Authors
  1. Tapan Kanti Paine
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  2. Lawrence Que Jr.
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Correspondence to Lawrence Que Jr. .

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Editors and Affiliations

  1. Department of Chemistry, University of North Carolina, Charlotte, North Carolina, USA

    Daniel Rabinovich

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Paine, T.K., Que, L. (2014). Dioxygen Activation by Biomimetic Iron Complexes of α-Keto Acids and α-Hydroxy Acids. In: Rabinovich, D. (eds) Molecular Design in Inorganic Biochemistry. Structure and Bonding, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/430_2014_144

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