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T-Cells in Multiple Sclerosis

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Abstract

Multiple sclerosis (MS) is a multifocal demyelinating disease of the central nervous system pathologically characterized by lesions of infiltrating macrophages and T cells. Multiple lines of evidence implicate that T cells play a central role in both mediating and regulating MS pathophysiology, and efforts to develop rational therapeutic strategies for MS have focused on understanding factors which control T cell function. T cells are a highly heterogeneous population comprised of multiple cell subtypes which mediate both adaptive immunity and specific tolerance. Much has been learned about the molecular signals that induce T cell activation and differentiation, and several effective treatments for MS act by altering these activation and differentiation pathways. In recent years, increasing recognition has been given to T cell subsets which serve immunosuppressive or regulatory functions, and it has been discovered that patients with MS have a functional defect in these cells. Current work is beginning to shed light on interactions of pathogenic and regulatory T cells with the intrinsic cells of the CNS to provide a more comprehensive picture of MS pathogenesis.

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  1. Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Christopher Severson & David A. Hafler

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  1. Christopher Severson
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  2. David A. Hafler
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Severson, C., Hafler, D.A. (2009). T-Cells in Multiple Sclerosis. In: Results and Problems in Cell Differentiation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/400_2009_12

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  • DOI: https://doi.org/10.1007/400_2009_12

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