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Stress Vulnerability Induced by Neonatal Isolation and the Disturbance Between the Phosphorylation and Dephosphorylation of CREB

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PTSD

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References

  • Abel T, Lattal KM (2001) Molecular mechanisms of memory acquisition, consolidation and retrieval. Curr Opin Neurobiol 11:180–187

    Article  PubMed  CAS  Google Scholar 

  • Bito H, Desseroth K, Tsien RW (1996) CREB phosphorylation and dephosphorylation: a Ca2+-and stimulus duration-dependent switch for hippocampal gene expression. Cell 87:1203–1214

    Article  PubMed  CAS  Google Scholar 

  • Bremner JD, Narayan M, Staib LH, Southwick SM, McGlashan T, Charney DS (1999) Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry 156:1787–1795

    PubMed  CAS  Google Scholar 

  • Caldji C, Francis D, Sharma S, Plotsky PM, Meaney MJ (2000) The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat. Neuropsychopharmacology 22:219–229

    Article  PubMed  CAS  Google Scholar 

  • Fairbank JA, Schlenger WE, Saigh PA, Davidson RT (1995) An epidemiologic profile of post-traumatic stress disorder. In: Friedman MJ, Charney DS, Deutch AY, (eds) Neurobiology and clinical consequences of stress. Lippincott-Raven, Philadelphia, pp 415–427

    Google Scholar 

  • Francis DD, Caldji C, Champagne F, Plotsky PM, Meaney MJ (1999) The role of corticotropin-releasing factor—norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress. Biol Psychiat 46:1153–1166

    Article  PubMed  CAS  Google Scholar 

  • Genoux D, Haditsch U, Knobloch M, Michalon A, Storm D, Mansuy IM (2002) Protein phosphatase 1 is a molecular constraint on learning and memory. Nature 418:970–975

    Article  PubMed  CAS  Google Scholar 

  • Kaufman J, Plotsky PM, Nemeroff CB, Charney DS (2000) Effects of early adverse experiences on brain structure and function: clinical implications. Biol Psychiat 48:778–790

    Article  PubMed  CAS  Google Scholar 

  • Kehoe P, Bronzino JD (1999) Neonatal stress alters LTP in freely moving male and female adult rats. Hippocampus 9:651–658

    Article  PubMed  CAS  Google Scholar 

  • Ladd CO, Owens MJ, Nemeroff CB (1996) Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation. Endocrinol 137:1212–1218

    Article  CAS  Google Scholar 

  • Lin C-H, Yeh S-H, Lu H-Y, Gean P-W (2003) The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory. J Neurosci 23:8310–8317

    PubMed  CAS  Google Scholar 

  • Lisman JE (1994) The CaM kinase II hypothesis for the storage of synaptic memory. Trends Neurosci 17:406–412

    Article  PubMed  CAS  Google Scholar 

  • Liu D, Caldji C, Sharma S, Plotsky PM, Meaney MJ (2000) Influence of neonatal rearing conditions on stress-induced adrenocorticotropin responses and norepinepherine release in the hypothalamic paraventricular nucleus. J Neuroendocrinol 12:5–12

    Article  PubMed  Google Scholar 

  • Mansuy IM, Mayford M, Jacob B, Kandel ER, Bach ME (1998) Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92:39–49

    Article  PubMed  CAS  Google Scholar 

  • Mathews RP, Guthrie CR, Wailes LM, Zhao X, Means AR, McKnight GT (1994) Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol Cell Biol 14:6107–6116

    Google Scholar 

  • Morinobu S, Russel DS, Sugawara S, Takahashi M, Fujimaki K (2000) Regulation of phosphorylation of cyclic AMP response element-binding protein by paroxetine treatments. Clin Neuropharmacol 23:106–109

    Article  PubMed  CAS  Google Scholar 

  • Morinobu S, Fujimaki K, Kawano K, Tanaka K, Takahashi J, Ohkawa M, Yamawaki S, Kato N (2003) Influence of immobilization stress on the expression and phosphatase activity of protein phosphatase 2A in the rat brain. Biol Psychiat 54:1060–1066

    Article  PubMed  CAS  Google Scholar 

  • Pine DS, Cohen JA (2002) Trauma in children and adolescents: risk and treatment of psychiatric sequelae. Biol Psychiat 51:519–531

    Article  PubMed  Google Scholar 

  • Plotsky PM, Meaney MJ (1993) Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Mol Brain Res 18:195–200

    Article  PubMed  CAS  Google Scholar 

  • Prins A, Kaloupek DG, Keane TM (1995) Psychophysiological evidence for autonomic arousal and startle in traumatized adult populations. In: Friedman MJ, Charney DS, Deuth AY (eds) Neurobiological and clinical consequences of stress. Lippincott-Raven, Philadelphia, pp 291–314

    Google Scholar 

  • Rothbaum BD, Davis M (2003) Applying learning principles to the treatment of post-trauma reactions. Ann N Y Acad Sci 1008:112–121

    Article  PubMed  Google Scholar 

  • Southwick SM, Davis M, Horner B, Cahill L, Morgan CA, Gold PE, Bremmenr JD, Charney DC (2002) Relationship of enhanced norepinephrine activity during memory consolidation to enhanced long-term memory in humans. Am J Psychiat 159:1420–1422

    Article  PubMed  Google Scholar 

  • Stemmer PM, Wang X, Krinks MH, Klee CB (1995) Factors responsible for the Ca2+-dependent inactivation of calcineurin in brain. FEBS Lett 374:237–240

    Article  PubMed  CAS  Google Scholar 

  • Takahashi J, Tanaka K, Morinobu S, Fujimaki K, Li S-T, Kato K, Ohkawa M, Yamawaki S, Kato N (2001) The influence of restraint stress on the expression and the serine/threonine phosphatase activity of calcineurin in the rat brain. Synapse 40:130–136

    Article  PubMed  CAS  Google Scholar 

  • Timmusk T, Palm K, Metsis M, Reitam T, Paalmee V, Sarma M, Persson H (1993) Multiple promoters direct tissue specific expression of the rat BDNF gene. Neuron 10:475–489

    Article  PubMed  CAS  Google Scholar 

  • Waltereit R, Weller M (2003) Signaling from cAMP/PKA to MAPK and synaptic plasticity. Mol Neurobiol 27:99–106

    Article  PubMed  CAS  Google Scholar 

  • Westphal RS, Anderson KA, Means AR, Wadzinski BE (1998) A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A. Science 280:1258–1261

    Article  PubMed  CAS  Google Scholar 

  • Westphal RS, Coffee RL Jr, Marotta A, Pelech SL, Wadzinski BE (1999) Identification of kinase-phosphatase signaling modulates composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A. J Biol Chem 274:687–692

    Article  PubMed  CAS  Google Scholar 

  • Winder DG, Mansuy IM, Osman M, Moallem TM, Kandel ER (1998) Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell 92:25–37

    Article  PubMed  CAS  Google Scholar 

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© 2006 Springer-Verlag Tokyo

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Morinobu, S. et al. (2006). Stress Vulnerability Induced by Neonatal Isolation and the Disturbance Between the Phosphorylation and Dephosphorylation of CREB. In: Kato, N., Kawata, M., Pitman, R.K. (eds) PTSD. Springer, Tokyo. https://doi.org/10.1007/4-431-29567-4_4

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