Summary
A nationwide survey documented 117 cases of Creutzfeldt-Jakob disease (CJD) transmitted from cadaveric dura mater grafts in Japan to September 2004. Of these, 110 patients were identified to have received the same type of lyophilized cadaveric dura mater graft during the period between 1978 and 1991. Incubation period from grafting to onset of symptoms varied from 16 months to 23 years, with most patients developing neurological symptoms after 2 to 15 years. We conducted q retrospective review of the full medical records of 107 of dura-related CJD (dCJD) patients. Patients were divided into two groups by site of neurosurgical or orthopedic procedure (supratentorial vs. infratentorial). Hemiparesis or hemianopsia developed as an initial manifestation in 31.9% of 47 patients with supratentorial grafts but did not develop among any of the infratentorial group (p<0.0001). Conversely, brainstem symptoms (nystagmus, diplopia, ipsilateral hearing loss, facial paresis or paresthesia) were noted in 25.0% of the infratentorial group, but were not seen in the supratentorium group (p<0.0001).
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© 2005 Springer-Verlag Tokyo
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Sato, T. et al. (2005). Dura mater related Creutzfeldt-Jakob disease in Japan: Relationship between sites of grafts and clinical features. In: Kitamoto, T. (eds) Prions. Springer, Tokyo. https://doi.org/10.1007/4-431-29402-3_3
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DOI: https://doi.org/10.1007/4-431-29402-3_3
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-25539-0
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