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An Oligonucleotide Carrier Based on β-1,3-Glucans

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Non-viral Gene Therapy

6 Conclusions

This study demonstrates the potential of SPG as an oligonucleotide carrier, for example, in antisense and CpG DNAs. The most distinguishing feature of this carrier compared to other cation types is that the driving force of the complexation is hydrogen bonds instead of electrostatic forces. Therefore, the total charge of the SPG/nucleotide complex is negative and there is no DNA-compaction problem in this system. Using chemically modified SPG, the antisense effect and CpG immunostimulatory response can be enhanced.

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Author information

Authors and Affiliations

  1. Department of Chemical Process & Environments, The University of Kitakyushu, 1-1 Hibikino, Wakamatu-ku, Kitakyushu, Fukuoka, 808-0135, Japan

    Kazuo Sakurai

  2. Faculty of Engineering, Department of Chemistry & Biochemistry, Graduate School of Engineering, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan

    Seiji Shinkai

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  1. Kazuo Sakurai
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  2. Seiji Shinkai
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Editor information

Editors and Affiliations

  1. Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

    Kazunari Taira Ph.D

  2. Gene Function Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba Science City, 305-8562, Japan

    Kazunari Taira Ph.D

  3. Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

    Kazunori Kataoka Ph.D

  4. Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan

    Takuro Niidome Ph.D

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Sakurai, K., Shinkai, S. (2005). An Oligonucleotide Carrier Based on β-1,3-Glucans. In: Taira, K., Kataoka, K., Niidome, T. (eds) Non-viral Gene Therapy. Springer, Tokyo. https://doi.org/10.1007/4-431-27879-6_9

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