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Recent Advances in Molecular Pathobiology of Gastric Carcinoma

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The Diversity of Gastric Carcinoma

Conclusion

In the course of multistep carcinogenesis of the stomach, various alterations of oncogenes, tumor suppressor genes, DNA repair genes, growth factors/receptors, cell-cycle regulators, and cell adhesion molecules are accumulated. Some of these changes occur commonly in both well-differentiated and poorly differentiated types and some differ depending on the histological types. Among various epigenetic alterations, modified gene expression through DNA methylation and chromatin remodeling by histone modification are the most important events. Genetic polymorphism is a crucial endogenous cause and fundamental factor of cancer risk. Using genomic science including novel techniques for global analysis of gene expression and bioinformatics, the individual character of each person and cancer can be dissected precisely, which is directly connected to personalized medicine and cancer prevention. Understanding of the diversity of gastric cancer must be critical in the era of genomic medicine at the clinical setting.

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Author information

Authors and Affiliations

  1. Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Wataru Yasui, Naohide Oue & Hirofumi Nakayama

  2. Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Yasuhiko Kitadai

Authors
  1. Wataru Yasui
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  2. Naohide Oue
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  3. Yasuhiko Kitadai
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  4. Hirofumi Nakayama
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Editor information

Editors and Affiliations

  1. Departments of Gastrointestinal Surgery, Surgical Metabolic Care and Endocrine Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Michio Kaminishi M.D., Ph.D.

  2. Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan

    Kaiyo Takubo M.D., Ph.D.

  3. Department of Gastrointestinal Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Ken-ichi Mafune M.D., Ph.D., F.A.C.S.

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Yasui, W., Oue, N., Kitadai, Y., Nakayama, H. (2005). Recent Advances in Molecular Pathobiology of Gastric Carcinoma. In: Kaminishi, M., Takubo, K., Mafune, Ki. (eds) The Diversity of Gastric Carcinoma. Springer, Tokyo. https://doi.org/10.1007/4-431-27713-7_3

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  • DOI: https://doi.org/10.1007/4-431-27713-7_3

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-21139-6

  • Online ISBN: 978-4-431-27713-2

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