Summary
Therapeutic angiogenesis has been successfully induced by various methods, and developed clinically as a new treatment for ischemic diseases. We have tried to induce therapeutic angiogenesis for the treatment of ischemic heart disease by the implantation of bone marrow mononuclear cells (BM-MNCs), because BM-MNCs consist of complex populations, including the endothelial progenitor and angiogenic cytokine-producing cells. Using the ischemic heart model in rats and dogs, we have demonstrated that the intramyocardial implantation of BM-MNCs is a feasible and safe method for inducing therapeutic angiogenesis and improving deteriorated cardiac function. Then, we performed the intramyocardial implantation of autologous BM-MNCs in eight patients with ischemic heart disease who underwent coronary arterial bypass graft (CABG) simultaneously. A specific increase in myocardial perfusion was seen in five patients, and two patients showed improved left ventricular wall motion, 1 and 12 months after treatment. No postoperative complications, new-onset malignant arrhythmias, mass formation or calcification, or any other abnormal signs related with this new therapy were detected in any of the patients by 3 years follow-up examination. Although further investigation on the safety and effect of cell-based therapy are required, our preliminary results indicated that the intramyocardial injection of BM-MNCs is a feasible and safe method of inducing therapeutic angiogenesis and improving cardiac function in patients with severe ischemic heart disease.
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© 2005 Springer-Verlag Tokyo
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Li, TS., Matsuzaki, M., Hamano, K. (2005). Angiogenesis Induced by Intramyocardial Implantation of Autologous Bone Marrow Mononuclear Cells for the Treatment of Ischemic Heart Disease. In: Mori, H., Matsuda, H. (eds) Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches. Springer, Tokyo. https://doi.org/10.1007/4-431-27378-6_17
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DOI: https://doi.org/10.1007/4-431-27378-6_17
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-23925-3
Online ISBN: 978-4-431-27378-3
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