Summary
Therapeutic delivery of bone marrow derived mononuclear cells (BMMNCs) into ischemic tissues would be able to improve blood flow. Vascular endothelial growth factor (VEGF) is known as a potent angiogenic growth factor. We injected sFLT-1 expressing plasmid into mice anterotibial muscle. One week after gene transfer, gap unilateral femoral arterial segments were removed and murine BMMNCs (1×104 cells) were delivered into the thigh muscle to make BMMNC delivery model. SFLT-1 gene transfer inhibited BMMNCs delivery-induced blood flow recovery. This finding suggests that the effect of BMMNCs delivery is at least partially mediated via VEGF.
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© 2005 Springer-Verlag Tokyo
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Maeda, Y., Ikeda, U. (2005). The Role of Vascular Endothelial Growth Factor (VEGF) on Therapeutic Angiogenesis Using Bone Marrow Cells. In: Mori, H., Matsuda, H. (eds) Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches. Springer, Tokyo. https://doi.org/10.1007/4-431-27378-6_14
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DOI: https://doi.org/10.1007/4-431-27378-6_14
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-23925-3
Online ISBN: 978-4-431-27378-3
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