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Transition-Metal-Catalyzed Difluoromethylation, Difluoromethylenation, and Polydifluoromethylenation Reactions

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Organometallic Fluorine Chemistry

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Abbreviations

bpy:

2,2′-Bipyridyl

Bu:

Butyl

cat:

Catalyst

d:

Day(s)

DBU:

1,8-Diazabicyclo [5.4.0]undec-7-ene

DCE:

1,2-Dichloroethane

DME:

1,2-Dimethoxyethane

DMF:

Dimethylformamide

DMPU:

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

DMSO:

Dimethyl sulfoxide

equiv.:

Equivalent(s)

Et:

Ethyl

h:

Hour(s)

i-Pr:

Isopropyl

M:

Metal

Me:

Methyl

MeCN:

Acetonitrile

min:

Minute(s)

mol:

Mole(s)

NMP:

N-Methyl-2-pyrrolidone

Ph:

Phenyl

rt:

Room temperature

tbpy:

4,4′-Di-tert-butyl-2,2′-dipyridyl

t-Bu:

tert-butyl

TFA:

Trifluoroacetic acid

THF:

Tetrahydrofuran

TMEDA:

N,N-N′,N′-Tetramethylethylenediamine

TMS:

Trimethylsilyl

Xantphos:

4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene

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  1. Lehigh University, 6 E. Packer Ave., Bethlehem, PA, 18015, USA

    Bo Chen & David A. Vicic

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  1. Institut für Chemie, Humboldt-Universität zu Berlin, Berlin, Germany

    Thomas Braun

  2. Dartmouth College, Hanover, New Hampshire, USA

    Russell P. Hughes

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Chen, B., Vicic, D.A. (2014). Transition-Metal-Catalyzed Difluoromethylation, Difluoromethylenation, and Polydifluoromethylenation Reactions. In: Braun, T., Hughes, R. (eds) Organometallic Fluorine Chemistry. Topics in Organometallic Chemistry, vol 52. Springer, Cham. https://doi.org/10.1007/3418_2014_87

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