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Bifunctional Molecular Catalysis pp 55–84Cite as

Bond Activation by Metal-Ligand Cooperation: Design of “Green” Catalytic Reactions Based on Aromatization-Dearomatization of Pincer Complexes

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Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 37))

Abstract

We have developed a new mode of bifunctional catalysis based on metal–ligand cooperation, involving aromatization–dearomatization of pyridine- and acridine-derived pincer complexes. This type of metal–ligand cooperation is involved in the recently discovered environmentally benign reactions of alcohols, catalyzed by PNP and PNN pincer complexes of ruthenium, including: (a) dehydrogenation of secondary alcohols to ketones, (b) dehydrogenative coupling of primary alcohols to form esters and H2, (c) unprecedented amide synthesis: catalytic coupling of amines with alcohols, with liberation of H2, (d) direct synthesis of imines from alcohols and amines with H2 liberation, (e) direct conversion of alcohols to acetals with H2 liberation, (f) selective synthesis of primary amines from alcohols and ammonia, and (g) hydrogenation of esters to alcohols under mild conditions. These reactions are very efficient, proceed under neutral conditions, and produce no waste.

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Acknowledgments

Our research described in this review was supported by the Israel Science Foundation, by the MINERVA Foundation, by the DIP program for German-Israeli Cooperation, by the European Research Council under the FP7 framework (ERC No 246837), and by the Kimmel Center for Molecular design. D.M. is the holder of the Israel Matz Professorial Chair of Organic Chemistry.

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Authors and Affiliations

  1. Department of Organic Chemistry, The Weizmann Institute of Science, 76100, Rehovot, Israel

    Chidambaram Gunanathan & David Milstein

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  1. Chidambaram Gunanathan
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  2. David Milstein
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Correspondence to David Milstein .

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Editors and Affiliations

  1. Graduate School of Science & Engineering, Dept. Applied Chemistry, Tokyo Institute of Technology, Ookayama 2-12-1, Tokyo, 152-8550, Japan

    Takao Ikariya

  2. Institute of Microbial Chemistry, Kamioosaki 3-14-23, Tokyo, 141-0021, Japan

    Masakatsu Shibasaki

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Gunanathan, C., Milstein, D. (2011). Bond Activation by Metal-Ligand Cooperation: Design of “Green” Catalytic Reactions Based on Aromatization-Dearomatization of Pincer Complexes. In: Ikariya, T., Shibasaki, M. (eds) Bifunctional Molecular Catalysis. Topics in Organometallic Chemistry, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3418_2011_6

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