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Lymphocyte migration to the brain

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Book cover Lymphocyte Trafficking in Health and Disease

Part of the book series: Progress in Inflammation Research ((PIR))

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Conclusion

Lymphocyte migration to the CNS is a tightly regulated process, which involves many cellular signaling cascades and molecules. Under normal conditions, lymphocyte migration to the CNS is limited and restricted to the perivascular spaces and CSF, but is thought to be important for CNS immunosurveillance. Here, the CP is most likely the “port of entry” for CD4+ central-memory T cells. Under pathological conditions, traffic signals are altered and expression of many adhesion molecules and chemokines permit lymphocytes to enter the CNS parenchyma where they need interaction with APCs to persist. The specific molecular mechanisms differ, depending on CNS site and stimuli, and need further exploration for better understanding and novel treatments of neuroinflammation.

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Authors and Affiliations

  1. Neuroinflammation Research Center, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Ineke M. Dijkstra & Richard M. Ransohoff

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  1. Ineke M. Dijkstra
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  1. Department of Pediatrics, University of Brescia, c/o Spedali Civili, 25123, Brescia, Italy

    Raffaele Badolato

  2. Section of General Pathology and Immunology, University of Brescia, Vle Europa 11, 25123, Brescia, Italy

    Silvano Sozzani

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Dijkstra, I.M., Ransohoff, R.M. (2006). Lymphocyte migration to the brain. In: Badolato, R., Sozzani, S. (eds) Lymphocyte Trafficking in Health and Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7442-X_8

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