Concluding remarks
Thus, TIR8 represents a negative pathway of regulation of the IL-1R/TLR system, with a unique pattern of expression in epithelial cells and DC, crucial for tuning inflammation at mucosal surfaces, in particular in the gastrointestinal tract. Further research is needed to explore the role of TIR8 in controlling inflammation at other mucosal tissues and to investigate its expression and involvement in the pathogenesis of human diseases, in particular in inflammatory bowel disease.
Keywords
- Dextran Sodium Sulfate
- Endotoxin Tolerance
- Receptor Accessory Protein
- Negative Regulatory Function
- TIR8 Gene
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Garlanda, C. et al. (2006). Tuning of inflammatory cytokines and toll-like receptors by TIR8/SIGIRR, a member of the IL-1 receptor family with unique structure and regulation. In: O’Neill, L.A., Brint, E. (eds) Toll-like Receptors in Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7441-1_11
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