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Chemokines in leukocyte transendothelial migration

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Book cover Chemokine Biology — Basic Research and Clinical Application

Part of the book series: Progress in Inflammation Research ((PIR))

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Conclusions

Chemokines function at all stages of leukocyte transendothelial migration. However, chemokines do not work alone. Selectins enhance chemokine-induced leukocyte transendothelial migration. Activation of p38 MAPK plays an important role in chemokine-induced transmigration. Unraveling the mechanisms of leukocyte transendothelial migration and the signaling pathways involved is now a major area of interest. Interactions between chemokines, adhesion molecules, the cytoskeleton, signaling kinases and other signaling factors need further exploration to provide new clues for novel therapies for the treatment of inflammatory diseases.

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Author information

Authors and Affiliations

  1. Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta, T2N 4N1, Canada

    Lixin Liu & Paul Kubes

Authors
  1. Lixin Liu
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  2. Paul Kubes
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Editor information

Editors and Affiliations

  1. Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland

    Bernhard Moser

  2. NitroMed, Inc., 12 Oak Park Drive, Bedford, MA, 01730, USA

    Gordon L. Letts

  3. Bone and Inflammation, Eli Lilly and Company Lilly Corporate Center, Indianapolis, IN, 46285, USA

    Kuldeep Neote

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© 2006 Birkhäuser Verlag Basel/Switzerland

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Liu, L., Kubes, P. (2006). Chemokines in leukocyte transendothelial migration. In: Moser, B., Letts, G.L., Neote, K. (eds) Chemokine Biology — Basic Research and Clinical Application. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7423-3_7

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