Skip to main content
SpringerLink
Log in

Traffic of T lymphocytes

  • Chapter
Book cover Chemokine Biology — Basic Research and Clinical Application

Part of the book series: Progress in Inflammation Research ((PIR))

  • 572 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Moser B, Wolf M, Walz A, Loetscher P (2004) Chemokines: multiple levels of leukocyte migration control. Trends Immunol 25: 75–84

    Article  CAS  PubMed  Google Scholar 

  2. Sallusto F, Mackay CR (2004) Chemoattractants and their receptors in homeostasis and inflammation. Curr Opin Immunol 16: 724–731

    Article  CAS  PubMed  Google Scholar 

  3. Von Andrian H, Mackay CR (2000) T-cell function and migration. Two sides of the same coin. N Engl J Med 343: 1020–1034

    Google Scholar 

  4. Von Andrian UH, Mempel TR (2003) Homing and cellular traffic in lymph nodes. Nat Rev Immunol 3: 867–878

    Google Scholar 

  5. Butcher EC, Williams M, Youngman K, Rott L, Briskin M (1999) Lymphocyte trafficking and regional immunity. Adv Immunol 72: 209–253

    CAS  PubMed  Google Scholar 

  6. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708–712

    Article  CAS  PubMed  Google Scholar 

  7. Gunn MD, Tangemann K, Tam C, Cyster JG, Rosen SD, Williams LT (1998) A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci USA 95: 258–263

    Article  CAS  PubMed  Google Scholar 

  8. Stein JV, Rot A, Luo Y, Narasimhaswamy M, Nakano H, Gunn MD, Matsuzawa A, Quackenbush EJ, Dorf ME, Von Andrian UH (2000) The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J Exp Med 191: 61–75

    Google Scholar 

  9. Baekkevold ES, Yamanaka T, Palframan RT, Carlsen HS, Reinholt FP, Von Andrian UH, Brandtzaeg P, Haraldsen G (2001) The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J Exp Med 193: 1105–1112

    Article  CAS  PubMed  Google Scholar 

  10. Muller G, Hopken UE, Stein H, Lipp M (2002) Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors. J Leukoc Biol 72: 1–8

    CAS  PubMed  Google Scholar 

  11. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K (2000) Immunobiology of dendritic cells. Annu Rev Immunol 18: 767–811

    Article  CAS  PubMed  Google Scholar 

  12. Steinman RM, Hawiger D, Nussenzweig MC (2003) Tolerogenic dendritic cells. Annu Rev Immunol 21: 685–711

    Article  CAS  PubMed  Google Scholar 

  13. Schaerli P, Ebert L, Willimann K, Blaser A, Roos RS, Loetscher P, Moser B (2004) A Skin-selective homing mechanism for human immune surveillance T cells. J Exp Med 199: 1265–1275

    Article  CAS  PubMed  Google Scholar 

  14. D’Ambrosio D, Sinigaglia F, Adorini L (2003) Special attractions for suppressor T cells. Trends Immunol 24: 122–126

    CAS  PubMed  Google Scholar 

  15. Kunkel EJ, Butcher EC (2002) Chemokines and the tissue-specific migration of lymphocytes. Immunity 16: 1–4

    Article  CAS  PubMed  Google Scholar 

  16. Olaussen RW, Farstad IN, Brandtzaeg P, Rugtveit J (2001) Age-related changes in CCR9+ circulating lymphocytes: are CCR9+ naive T cells recent thymic emigrants? Scand J Immunol 54: 435–439

    Article  CAS  PubMed  Google Scholar 

  17. Okada T, Ngo VN, Ekland EH, Forster R, Lipp M, Littman DR, Cyster JG (2002) Chemokine requirements for B cell entry to lymph nodes and Peyer’s patches. J Exp Med 196: 65–75

    Article  CAS  PubMed  Google Scholar 

  18. Phillips R, Ager A (2002) Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells. Eur J Immunol 32: 837–847

    Article  CAS  PubMed  Google Scholar 

  19. Lanzavecchia A, Sallusto F (2002) Progressive differentiation and selection of the fittest in the immune response. Nat Rev Immunol 2: 982–987

    Article  CAS  PubMed  Google Scholar 

  20. Schaerli P, Loetscher P, Moser B (2001) Cutting edge: induction of follicular homing precedes effector Th cell development. J Immunol 167: 6082–6086

    CAS  PubMed  Google Scholar 

  21. Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG (1999) In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med 190: 1123–1134

    Article  CAS  PubMed  Google Scholar 

  22. Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (1998) B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 187: 655–660

    Article  CAS  PubMed  Google Scholar 

  23. Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (1998) A B-cell-homing chemokine made in lymphoid follicles activates Burkitt’s lymphoma receptor-1. Nature 391: 799–803

    CAS  PubMed  Google Scholar 

  24. Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B (2000) CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 192: 1553–1562

    Article  CAS  PubMed  Google Scholar 

  25. Muller G, Hopken UE, Lipp M (2003) The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity. Immunol Rev 195: 117–135

    Article  PubMed  Google Scholar 

  26. Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M (1996) A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87: 1037–1047

    PubMed  Google Scholar 

  27. Gulbranson-Judge A, MacLennan I (1996) Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c. Eur J Immunol 26: 1830–1837

    CAS  PubMed  Google Scholar 

  28. Garside P, Ingulli E, Merica RR, Johnson JG, Noelle RJ, Jenkins MK (1998) Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281: 96–99

    Article  CAS  PubMed  Google Scholar 

  29. Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, Forster R (2000) Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 192: 1545–1552

    Article  CAS  PubMed  Google Scholar 

  30. Langenkamp A, Nagata K, Murphy K, Wu L, Lanzavecchia A, Sallusto F (2003) Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells. Eur J Immunol 33: 474–482

    Article  CAS  PubMed  Google Scholar 

  31. Ebert LM, Horn MP, Lang AB, Moser B (2004) B cells alter the phenotype and function of follicular-homing CXCR5+ T cells. Eur J Immunol 34: 3562–3571

    Article  CAS  PubMed  Google Scholar 

  32. Mak TW, Shahinian A, Yoshinaga SK, Wakeham A, Boucher LM, Pintilie M, Duncan G, Gajewska BU, Gronski M, Eriksson U et al (2003) Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat Immunol 4: 765–772

    Article  CAS  PubMed  Google Scholar 

  33. Mackay CR (2001) Chemokines: immunology’s high impact factors. Nat Immunol 2: 95–101

    CAS  PubMed  Google Scholar 

  34. Butcher EC, Picker LJ (1996) Lymphocyte homing and homeostasis. Science 272: 60–66

    CAS  PubMed  Google Scholar 

  35. Sallusto F, Lanzavecchia A, Mackay CR (1998) Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today 19: 568–574

    Article  CAS  PubMed  Google Scholar 

  36. Syrbe U, Siveke J, Hamann A (1999) Th1/Th2 subsets: distinct differences in homing and chemokine receptor expression? Springer Semin Immunopathol 21: 263–285

    CAS  PubMed  Google Scholar 

  37. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A (1998) Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 187: 875–883

    Article  CAS  PubMed  Google Scholar 

  38. Bonecchi R, Bianchi G, Bordignon PP, D’Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A et al (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187: 129–134

    Article  CAS  PubMed  Google Scholar 

  39. Loetscher P, Uguccioni M, Bordoli L, Baggiolini M, Moser B, Chizzolini C, Dayer J-M (1998) CCR5 is characteristic of Th1 lymphocytes. Nature 391: 344–345

    Article  CAS  PubMed  Google Scholar 

  40. Qin SX, Rottman JB, Myers P, Kassam N, Weinblatt M, Loetscher M, Koch AE, Moser B, Mackay CR (1998) The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest 101: 746–754

    CAS  PubMed  Google Scholar 

  41. Paxton WA, Kang S (1998) Chemokine receptor allelic polymorphisms: relationships to HIV resistance and disease progression. Semin Immunol 10: 187–194

    Article  CAS  PubMed  Google Scholar 

  42. Gomez-Reino JJ, Pablos JL, Carreira PE, Santiago B, Serrano L, Vicario JL, Balsa A, Figueroa M, De Juan MD (1999) Association of rheumatoid arthritis with a functional chemokine receptor, CCR5. Arthritis Rheum 42: 989–992

    CAS  PubMed  Google Scholar 

  43. Austrup F, Vestweber D, Borges E, Löhning M, Bräuer R, Herz U, Renz H, Hallmann R, Scheffold A, Radbruch A et al (1997) P-and E-selectin mediate recruitment of Thelper-1 but not T-helper-2 cells into inflamed tissues. Nature 385: 81–83

    Article  CAS  PubMed  Google Scholar 

  44. Borges E, Tietz W, Steegmaier M, Moll T, Hallmann R, Hamann A, Vestweber D (1997) P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin. J Exp Med 185: 573–578

    Article  CAS  PubMed  Google Scholar 

  45. Xie HJ, Lim YC, Luscinskas FW, Lichtman AH (1999) Acquisition of selectin binding and peripheral homing properties by CD4+ and CD8+ T cells. J Exp Med 189: 1765–1775

    Article  CAS  PubMed  Google Scholar 

  46. Maly P, Thall AD, Petryniak B, Rogers GE, Smith PL, Marks RM, Kelly RJ, Gersten KM, Cheng GY, Saunders TL et al (1996) The a(1,3)Fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell 86: 643–653

    Article  CAS  PubMed  Google Scholar 

  47. Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH (1999) Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J Immunol 162: 3193–3201

    CAS  PubMed  Google Scholar 

  48. Wagers AJ, Waters CM, Stoolman LM, Kansas GS (1998) Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on alpha1, 3-fucosyltransferase VII gene expression. J Exp Med 188: 2225–2231

    Article  CAS  PubMed  Google Scholar 

  49. Sallusto F, Mackay CR, Lanzavecchia A (1997) Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277: 2005–2007

    Article  CAS  PubMed  Google Scholar 

  50. Gerber BO, Zanni MP, Uguccioni M, Loetscher M, Mackay CR, Pichler WJ, Yawalkar N, Baggiolini M, Moser B (1997) Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils. Curr Biol 7: 836–843

    Article  CAS  PubMed  Google Scholar 

  51. Sundrud MS, Grill SM, Ni D, Nagata K, Alkan SS, Subramaniam A, Unutmaz D (2003) Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation. J Immunol 171: 3542–3549

    CAS  PubMed  Google Scholar 

  52. Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ (1994) Eotaxin: A potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med 179: 881–887

    Article  CAS  PubMed  Google Scholar 

  53. Ponath PD, Qin SX, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi XJ, Gonzalo JA, Newman W et al (1996) Cloning of the human eosinophil chemoattractant, eotaxin — Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest 97: 604–612

    CAS  PubMed  Google Scholar 

  54. Chensue SW, Lukacs NW, Yang TY, Shang X, Frait KA, Kunkel SL, Kung T, Wiekowski MT, Hedrick JA, Cook DN et al (2001) Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med 193: 573–584

    Article  CAS  PubMed  Google Scholar 

  55. Goya I, Villares R, Zaballos A, Gutierrez J, Kremer L, Gonzalo JA, Varona R, Carramolino L, Serrano A, Pallares P et al (2003) Absence of CCR8 does not impair the response to ovalbumin-induced allergic airway disease. J Immunol 170: 2138–2146

    CAS  PubMed  Google Scholar 

  56. Chung CD, Kuo F, Kumer J, Motani AS, Lawrence CE, Henderson WR Jr, Venkataraman C (2003) CCR8 is not essential for the development of inflammation in a mouse model of allergic airway disease. J Immunol 170: 581–587

    CAS  PubMed  Google Scholar 

  57. Chong BF, Murphy JE, Kupper TS, Fuhlbrigge RC (2004) E-selectin, thymus-and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosur-veillance system. J Immunol 172: 1575–1581

    CAS  PubMed  Google Scholar 

  58. Reiss Y, Proudfoot AE, Power CA, Campbell JJ, Butcher EC (2001) CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J Exp Med 194: 1541–1547

    Article  CAS  PubMed  Google Scholar 

  59. Biedermann T, Schwarzler C, Lametschwandtner G, Thoma G, Carballido-Perrig N, Kund J, De Vries JE, Rot A, Carballido JM (2002) Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo. Eur J Immunol 32: 3171–3180

    Article  CAS  PubMed  Google Scholar 

  60. Sakaguchi S (2004) Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22: 531–562

    Article  CAS  PubMed  Google Scholar 

  61. Stock P, Akbari O, Berry G, Freeman GJ, DeKruyff RH, Umetsu DT (2004) Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nat Immunol 5: 1149–1156

    Article  CAS  PubMed  Google Scholar 

  62. Szanya V, Ermann J, Taylor C, Holness C, Fathman CG (2002) The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol 169: 2461–2465

    CAS  PubMed  Google Scholar 

  63. Apostolou I, Sarukhan A, Klein L, Von Boehmer H (2002) Origin of regulatory T cells with known specificity for antigen. Nat Immunol 3: 756–763

    CAS  PubMed  Google Scholar 

  64. Lim HW, Hillsamer P, Kim CH (2004) Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest 114: 1640–1649

    Article  CAS  PubMed  Google Scholar 

  65. Cao D, van Vollenhoven R, Klareskog L, Trollmo C, Malmstrom V (2004) CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther 6: R335–R346

    Article  CAS  PubMed  Google Scholar 

  66. Huehn J, Siegmund K, Lehmann JC, Siewert C, Haubold U, Feuerer M, Debes GF, Lauber J, Frey O, Przybylski GK et al (2004) Developmental stage, phenotype, and migration distinguish naive-and effector/memory-like CD4+ regulatory T cells. J Exp Med 199: 303–313

    Article  CAS  PubMed  Google Scholar 

  67. Iellem A, Mariani M, Lang R, Recalde H, Panina-Bordignon P, Sinigaglia F, D’Ambrosio D (2001) Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med 194: 847–853

    Article  CAS  PubMed  Google Scholar 

  68. Annunziato F, Cosmi L, Liotta F, Lazzeri E, Manetti R, Vanini V, Romagnani P, Maggi E, Romagnani S (2002) Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. J Exp Med 196: 379–387

    Google Scholar 

  69. Mackay CR (1991) T-cell memory: the connection between function, phenotype and migration pathways. Immunol Today 12: 189–192

    Article  CAS  PubMed  Google Scholar 

  70. Mora JR, Bono MR, Manjunath N, Weninger W, Cavanagh LL, Rosemblatt M, Von Andrian UH (2003) Selective imprinting of gut-homing T cells by Peyer’s patch dendritic cells. Nature 424: 88–93

    Article  CAS  PubMed  Google Scholar 

  71. Mora JR, Cheng G, Picarella D, Briskin M, Buchanan N, Von Andrian UH (2005) Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin-and gut-associated lymphoid tissues. J Exp Med 201: 303–316

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia

    Charles R. Mackay

  2. Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland

    Bernhard Moser

Authors
  1. Charles R. Mackay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bernhard Moser
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland

    Bernhard Moser

  2. NitroMed, Inc., 12 Oak Park Drive, Bedford, MA, 01730, USA

    Gordon L. Letts

  3. Bone and Inflammation, Eli Lilly and Company Lilly Corporate Center, Indianapolis, IN, 46285, USA

    Kuldeep Neote

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Mackay, C.R., Moser, B. (2006). Traffic of T lymphocytes. In: Moser, B., Letts, G.L., Neote, K. (eds) Chemokine Biology — Basic Research and Clinical Application. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7423-3_2

Download citation

Publish with us

Policies and ethics

Search

Navigation