Skip to main content
SpringerLink
Log in

Numerical Study of Effects of Co-transmission by Substance P and Acetylcholine on Synaptic Plasticity in Myenteric Neurons

  • Conference paper
  • First Online:
Book cover Connectionist Models of Neurons, Learning Processes, and Artificial Intelligence (IWANN 2001)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 2084))

Included in the following conference series:

  • 1418 Accesses

Abstract

The biological effect of synaptic co-transmission by substance P (SP) and acetylcholine (ACh) in neurons of the myenteric nervous plexus has been studied numerically. The model, based on known neuroanatomical, biochemical, and pharmacological experimental data about the dynamics of cotransmission of SP and ACh, includes the activation of voltage-dependent ion channels and the second messenger system through the selective binding of neurotransmitters to NK1 and muscarinic receptor subtypes located on the postsynaptic membrane. The simulations reproduce the electrophysiological and pharmacodynamical behaviors that observed in natural experiments.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Costa, M., Brookes, S. J. H., Steele, P. A., Gibbins, I., Burcher, E., and Kandiah, C. J. Neurochemical classification of myenteric neurons in the guinea-pig ileum. Neuroscience, 75 (1996) 949–967

    Article  Google Scholar 

  2. Furness, J. B., Young, H. M., Pompolo, S., Bornstein, J. C., Kunze, W. A. A., and McConalogue, K. Plurichemical transmission and chemical coding of neurons in the digestive tract. Gastroenterol., 108 (1995) 554–563

    Article  Google Scholar 

  3. Grider, J. R., and Bonilla, O. M. Differential expression of substance P, somatostatin, and VIP in neurones from cultured myenteric ganglia. Am. J. Physiol., 267 (1994) G322–327

    Google Scholar 

  4. Holzer, P., and Holzer-Petsche, U. Tachykinins in the gut. Part. I. Expression, release and motor function. Pharmacol-Ther., 73 (1997) 173–217

    Article  Google Scholar 

  5. Johnson, S. M., Bornstein, J. C., Yuan, S. Y., and Furness, J. B. Analysis of contributions of acetylcholine and tachykinins to neuro-neuronal transmission in motility reflexes in the guinea-pig ileum. Brit. J. Pharm., 118 (1996) 973–983

    Google Scholar 

  6. Kimball, B. C., Mulholland, M. W. Neuroligands evoke calcium signalling in cultured myenteric neurones. Surgery, 118 (1995) 162–169

    Article  Google Scholar 

  7. Miftakhov, R. N., and Wingate, D. L. Mathematical modeling of the enteric nervous network. 1:Cholinergic neuron. J. Med. Eng. & Phys., 16 (1994) 67–738

    Article  Google Scholar 

  8. Miftakhov, R. N., and Christensen, J. Cotransmission by substance P and acetylcholine in the myenteric plexus. In: Proc. Int. ICSC Congress on Intel. Syst. & Appl. (ISA’2000), Dec. 12-15, 2000, Wollongong, Australia

    Google Scholar 

  9. Moore, B. A., Vanner, S., Bunnett, N. W., and Sharkey, K. A. Characterization of neurokinin-1 receptors in the submucosal plexus of guinea pig ileum. Am.J. Physiol. 273 (1997) G670–G678.

    Google Scholar 

  10. Sarosi, G. A., Kimball, B. C., Barnhart, D. C., Weizhen, Z., and Mulholland, M. W. Tachykinin neurpeptide-evoked intracellular calcium transients in cultured guinea-pig myenteric neurons. Peptides, 19 (1998) 75–84

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. Radiology, University of Iowa, Iowa city, IA, 52242, USA

    Roustem Miftakov

  2. Dept. Internatl Medicine, University of Iowa, Iowa city, IA, 52242, USA

    James Christensen

Authors
  1. Roustem Miftakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. James Christensen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Departamento de Inteligencia Artificial Sanda del Rey, Universidad Nacional de Educación a Distancia, s/n., Madrid, 28040, Spain

    José Mira

  2. Departamento de Arquitectura y Tecnología de Computadores, Universidad de Granada, Campus Fuentenueva, 18071, Granada, Spain

    Alberto Prieto

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Miftakov, R., Christensen, J. (2001). Numerical Study of Effects of Co-transmission by Substance P and Acetylcholine on Synaptic Plasticity in Myenteric Neurons. In: Mira, J., Prieto, A. (eds) Connectionist Models of Neurons, Learning Processes, and Artificial Intelligence. IWANN 2001. Lecture Notes in Computer Science, vol 2084. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45720-8_8

Download citation

  • DOI: https://doi.org/10.1007/3-540-45720-8_8

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42235-8

  • Online ISBN: 978-3-540-45720-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation