Skip to main content
SpringerLink
Log in
Book cover

Springer Handbook of Enzymes pp 1–18Cite as

Glycine hydroxymethyltransferase

  • Chapter

  • 646 Accesses

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume 29))

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ide, H.; Hamaguchi, K.; Kobata, S.; Murakami, A.; Kimura, Y.; Makino, K.; Kamada, M.; Miyamoto, S.; Nagaya, T.; et al.: Purification of serine hydroxymethyltransferase from Bacillus stearothermophilus with ion-exchange high-performance liquid chromatography. J. Chromatogr., 596, 203–209 (1992)

    Article  PubMed  CAS  Google Scholar 

  2. Henricson, D.; Ericson, I.: Serine hydroxymethyltransferase from spinach leaf mitochondria. Purification and characterization. Physiol. Plant., 74, 602–606 (1988)

    Article  CAS  Google Scholar 

  3. Manca de Nadra, M.C.; Raya, R.R.; Holgado, A. Pesce de Ruiz, Oliver, G.: Isolation and properties of threonine aldolase of Lactobacillus bulgaricus YOP12. Milchwissenschaft, 42, 92–94 (1987)

    CAS  Google Scholar 

  4. Manohar, R.; Ramesh, K.S.; Rao, N.A.: Purification, physicochemical and regulatory properties of serine hydroxymethyltransferase from sheep liver. J. Biosci., 4, 31–50 (1982)

    Article  CAS  Google Scholar 

  5. Schirch, L.; Peterson, D.: Purification and properties of mitochondrial serine hydroxymethyltransferase. J. Biol. Chem., 255, 7801–7806 (1980)

    PubMed  CAS  Google Scholar 

  6. Ulevitch, R.J.; Kallen, R.G.: Purification and characterization of pyridoxal 5-phosphate dependent serine hydroxymethylase from lamb liver and its action upon β-phenylserines. Biochemistry, 16, 5342–5350 (1977)

    Article  PubMed  CAS  Google Scholar 

  7. Ulevitch, R.J.; Kallen, R.G.: Studies of the reactions of lamb liver serine hydroxymethylase with L-phenylalanine: kinetic isotope effects upon quinonoid intermediate formation. Biochemistry, 16, 5350–5354 (1977)

    Article  PubMed  CAS  Google Scholar 

  8. Ulevitch, R.J.; Kallen, R.G.: Studies of the reactions of substituted D,L-ery-thro-β-phenylserines with lamb liver serine hydroxymethylase. Effects of substituents upon the dealdolization step. Biochemistry, 16, 5355–5363 (1977)

    Article  PubMed  CAS  Google Scholar 

  9. Masuda, T.; Sakamoto, M.; Nishizaki, I.; Hayashi, H.; Yamamoto, M.; Wada, H.: Affinity purification and characterization of serine hydroxymethyl-transferases from rat liver. J. Biochem., 101, 643–652 (1987)

    Article  PubMed  CAS  Google Scholar 

  10. Ogawa, H.; Fujioka, M.: Purification and characterization of cytosolic and mitochondrial serine hydroxymethyltransferases from rat liver. J. Biochem., 90, 381–390 (1981)

    PubMed  CAS  Google Scholar 

  11. Schirch, L.; Gross, T.: Serine transhydroxymethylase. Identification as the threonine and allothreonine aldolases. J. Biol. Chem., 243, 5651–5655 (1968)

    PubMed  CAS  Google Scholar 

  12. Fujioka, M.: Purification and properties of serine hydroxymethylase from soluble and mitochondrial fractions of rabbit liver. Biochim. Biophys. Acta, 185, 338–349 (1969)

    PubMed  CAS  Google Scholar 

  13. Akhtar, M.; El-Obeid, H.A.: Interaction of serine transhydroxymethylase and threonine aldolase activities. Biochim. Biophys. Acta, 791, 791–799 (1972)

    Google Scholar 

  14. Ramesh, K.S.; Rao, N.A.: Purification and physicochemical, kinetic and im-munological properties of allosteric serine hydroxymethyltransferase from monkey liver. Biochem. J., 187, 623–636 (1980)

    PubMed  CAS  Google Scholar 

  15. Ramesh, K.S.; Rao, N.A.: Inhibition of monkey liver serine hydroxymethyltransferase by Cibacron Blue 3G-A. Biochem. J., 187, 249–252 (1980)

    PubMed  CAS  Google Scholar 

  16. Strong, W.B.; Tendler, S.J.; Seither, R.L.; Goldman, I.D.; Schirch, V.: Purification and properties of serine hydroxymethyltransferase and C1-tetrahydro-folate synthase from L1210 cells. J. Biol. Chem., 265, 12149–12155 (1990)

    PubMed  CAS  Google Scholar 

  17. Bourguignon, J.; Neuburger, M.; Douce, R.: Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase. Biochem. J., 255, 169–178 (1988)

    PubMed  CAS  Google Scholar 

  18. Mitchell, M.K.; Reynolds, P.H.S.; Blevins, D.G.: Serine hydroxymethyltransferase from soybean root nodules. Plant Physiol., 81, 553–557 (1986)

    PubMed  CAS  Google Scholar 

  19. Rao, D.N.; Rao, N.A.: Purification and regulatory properties of mung bean (Vigna Radiata L.) serine hydroxymethyltransferase. Plant Physiol., 69, 11–18 (1982)

    Article  PubMed  CAS  Google Scholar 

  20. Sakamoto, M.; Masuda, T.; Yanagimoto, Y.; Nakano, Y.; Kitaoka, S.: Purification and characterization of cytosolic serine hydroxymethyltransferase from Euglena gracilis z. Agric. Biol. Chem., 55, 2243–2249 (1991)

    CAS  Google Scholar 

  21. Miyazaki, S.S.; Toki, S.; Izumi, Y.; Yamada, H.: Purification and characterization of a serine hydroxymethyltransferase from an obligate methylotroph, Hyphomicrobium methylovorum GM2. Eur. J. Biochem., 162, 533–540 (1987)

    Article  PubMed  CAS  Google Scholar 

  22. Miyazaki, S.S.; Toki, S.; Izumi, Y.; Yamada, H.: Futher characterization of serine hydroxymethyltransferase from a serine-producing methylotroph, Hyphomicrobium methylovorum. Agric. Biol. Chem., 51, 2587–2589 (1987)

    CAS  Google Scholar 

  23. Schirch, V.; Hopkins, S.; Villar, E.; Angelaccio, S.: Serine hydroxymethyltransferase from Escherichia coli: purification and properties. J. Bacteriol., 163, 1–7 (1985)

    PubMed  CAS  Google Scholar 

  24. Nakamura, K.D.; Trewyn, R.W.; Parks, L.W.: Purification and characterization of serine transhydroxy-methylase from Saccharomyces cerevisiae. Biochim. Biophys. Acta, 327, 328–335 (1973)

    PubMed  CAS  Google Scholar 

  25. Ching, W.M.; Kallen, R.G.: Mechanism of serine hydroxymethylase catalyzed cleavage of l-erythro-β-phenylserine: pH dependence of elementary kinetic processes from spectroscopic, pre-steady kinetic, and competitive inhibition studies. Biochemistry, 18, 821–830 (1979)

    Article  PubMed  CAS  Google Scholar 

  26. El-Obeid, H.A.; Akhtar, M.: Glycidaldehyde, an inhibitor directed towards the C1-units-binding site of serine transhydoxymethylase. Biochem. Soc. Trans., 1, 1274–1276 (1973)

    CAS  Google Scholar 

  27. Manohar, R.; Rao, A.G.A.; Rao, N.A.: Kinetic mechanism of the interaction of d-cycloserine with serine hydroxymethyltransferase. Biochemistry, 23, 4116–4122 (1984)

    Article  PubMed  CAS  Google Scholar 

  28. Malthouse, J.P.G.; Milne, J.J.; Gariani, L.S.: A comparative study of the kinetics and stereochemistry of the serine hydroxymethyltransferase-and tryptophan synthase-catalysed exchange of the pro-2R and pro-2S protons of glycine. Biochem. J., 274, 807–812 (1991)

    PubMed  CAS  Google Scholar 

  29. Stover, P.; Schirch, V.: 5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase. J. Biol. Chem., 266, 1543–1550 (1991)

    PubMed  CAS  Google Scholar 

  30. Akhtar, M.; El-Obeida, H.A.; Jordan, P.M.: Mechanistic, inhibitory and stereochemical studies on cytoplasmic and mitochondrial serine transhy-dorxymethylases. Biochem. J., 145, 159–168 (1975)

    PubMed  CAS  Google Scholar 

  31. Schirch, L.: Serine hydroxymethyltransferase. Adv. Enzymol. Relat. Areas Mol. Biol., 53, 83–112 (1982)

    Article  PubMed  CAS  Google Scholar 

  32. Kruschwitz, H.; Ren, S.; Di Salvo, M.; Schifch, V.: Expression, purification, and characterization of human cytosolic serine hydroxymethyltransferase. Protein Expr. Purif., 6, 411–416 (1995)

    Article  PubMed  CAS  Google Scholar 

  33. Fratte, S.D.; White, R.H.; Maras, B.; Bossa, F.; Schirch, V.: Purification and properties of serine hydroxymethyltransferase from Sulfolobus solfataricus. J. Bacteriol., 179, 7456–7461 (1997)

    CAS  Google Scholar 

  34. Di Salvo, M.L.; Delle Fratte, S.; De Biase, D.; Bossa, F.; Schirch, V.: Purification and characterization of recombinant rabbit cytosolic serine hydroxymethyltransferase. Protein Expr. Purif., 13, 177–183 (1998)

    Article  PubMed  Google Scholar 

  35. Contestabile, R.; Paiardini, A.; Pascarella, S.; Di Salvo, M.L.; DÁguanno, S.; Bossa, F.: l-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions. Eur. J. Biochem., 268, 6508–6525 (2001)

    Article  PubMed  CAS  Google Scholar 

  36. Jagath-Reddy, J.; Ganesan, K.; Savithri, H.S.; Datta, A.; Rao, N.A.: cDNA cloning, overexpression in Escherichia coli, purification and characterization of sheep liver cytosolic serine hydroxymethyltransferase. Eur. J. Biochem., 230, 533–537 (1995)

    Article  PubMed  CAS  Google Scholar 

  37. Brahatheeswaran, B.; Prakash, V.; Savithri, H.S.; Rao, N.A.: Interaction of sheep liver apo-serine hydroxymethyltransferase with pyridoxal-5′-phos-phate: a physicochemical, kinetic, and thermodynamic study. Arch. Biochem. Biophys., 330, 363–372 (1996)

    Article  PubMed  CAS  Google Scholar 

  38. Appaji Rao, N.; Talwar, R.; Savithri, H.S.: Molecular organization, catalytic mechanism and function of serine hydroxymethyltransferase-a potential target for cancer chemotherapy. Int. J. Biochem. Cell Biol., 32, 405–416 (2000)

    Article  CAS  Google Scholar 

  39. Talwar, R.; Leelavathy, V.; Rao, J.V.K.; Rao, N.A.; Savithri, H.S.: Role of Pro-297 in the catalytic mechanism of sheep liver serine hydroxymethyltransferase. Biochem. J., 350, 849–853 (2000)

    Article  PubMed  CAS  Google Scholar 

  40. Talwar, R.; Appaji Rao, N.; Savithri, H.S.: A change in reaction specificity of sheep liver serine hydroxymethyltransferase: induction of NADH oxidation upon mutation of His230 to Tyr. Eur. J. Biochem., 267, 929–934 (2000)

    Article  PubMed  CAS  Google Scholar 

  41. Rao, J.V.K.; Prakash, V.; Appaji Rao, N.; Savithri, H.S.: The role of Glu74 and Tyr82 in the reaction catalyzed by sheep liver cytosolic serine hydroxymethyltransferase. Eur. J. Biochem., 267, 5967–5976 (2000)

    Article  PubMed  CAS  Google Scholar 

  42. Trivedi, V.; Gupta, A.; Jala, V.R.; Saravanan, P.; Rao, G.S.J.; Rao, N.A.; Savi-thri, H.S.; Subramanya, H.S.: Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophi-lus: insights into the catalytic mechanism. J. Biol. Chem., 277, 17161–17169 (2002)

    Article  PubMed  CAS  Google Scholar 

  43. Jala, V.R.; Prakash, V.; Rao, N.A.; Savithri, H.S.: Overexpression and characterization of dimeric and tetrameric forms of recombinant serine hydroxymethyltransferase from Bacillus stearothermophilus. J. Biosci., 27, 233–242 (2002)

    Article  PubMed  CAS  Google Scholar 

  44. Liu, J.Q.; Ito, S.; Dairi, T.; Itoh, N.; Kataoka, M.; Shimizu, S.; Yamada, H.: Gene cloning, nucleotide sequencing, and purification and characterization of the low-specificity l-threonine aldolase from Pseudomonas sp. strain NCIMB 10558. Appl. Environ. Microbiol., 64, 549–554 (1998)

    PubMed  CAS  Google Scholar 

  45. Ogawa, H.; Gomi, T.; Fujioka, M.: Serine hydroxymethyltransferase and threonine aldolase: are they identical?. Int. J. Biochem. Cell Biol., 32, 289–301 (2000)

    Article  PubMed  CAS  Google Scholar 

  46. Chave, K.J.; Snell, K.; Sanders, P.G.: Isolation and characterization of human genomic sequences encoding cytosolic serine hydroxymethyltransferase. Biochem. Soc. Trans., 25, 53S (1997)

    PubMed  CAS  Google Scholar 

  47. Liu, X.; Reig, B.; Nasrallah, I.M.; Stover, P.J.: Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein. Biochemistry, 39, 11523–11531 (2000)

    Article  PubMed  CAS  Google Scholar 

  48. Sakamoto, M.; Masuda, T.; Yanagimoto, Y.; Nakano, Y.; Kitaoka, S.; Taniga-wa, Y.: Purification and characterization of serine hydroxymethyltransferase from mitochondria of Euglena gracilis z. Biosci. Biotechnol. Biochem., 60, 1941–1944 (1996)

    Article  CAS  Google Scholar 

  49. Vatcher, G.P.; Barbazuk, W.B.; O’Neil, N.J.; Marra, M.A.; Ha, T.; Baillie, D.L.: Identification and characterization of a serine hydroxymethyltransferase isoform in Caenorhabditis briggsae. Gene, 230, 137–144 (1999)

    Article  PubMed  CAS  Google Scholar 

Download references

Editor information

Editors and Affiliations

  1. Institute for Biochemistry, University to Cologne, Zülpicher Strasse 47, 50674, Cologne, Germany

    Dietmar Schomburg , Ida Schomburg  & Antje Chang ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

(2006). Glycine hydroxymethyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37716-6_1

Download citation

Publish with us

Policies and ethics

Search

Navigation