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Immunological Causes

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Andrology for the Clinician

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References

  • Ackerman SB, Wortham JW, Swanson RJ (1981) An indirect enzyme-linked immunosorbent assay (ELISA) for the detection and quantitation of antisperm antibodies. Am J Reprod Immunol 1:199–205

    PubMed  CAS  Google Scholar 

  • Ackerman S, McGuire G, Fulgham DL, Alexander NJ (1988) An evaluation of a commercially available assay for the detection of antisperm antibodies. Fertil Steril 49:732–734

    PubMed  CAS  Google Scholar 

  • Andreou E, Mahmoud A, Vermeulen L, Schoonjans F, Comhaire F (1995) Comparison of different methods for the investigation of antisperm antibodies on spermatozoa, in seminal plasma and in serum. Hum Reprod 10:125–131

    PubMed  CAS  Google Scholar 

  • Bals-Pratsch M, Doren M, Karbowski B, Schneider HP, Nieschlag E (1992) Cyclic corticosteroid immunosuppression is unsuccessful in the treatment of sperm antibody-related male infertility: a controlled study. Hum Reprod 7:99–104

    PubMed  CAS  Google Scholar 

  • Beer AE, Neaves WB (1978) Antigenic status of semen from the viewpoints of the female and male. Fertil Steril 29:3–22

    PubMed  CAS  Google Scholar 

  • Billingham RE, Brent L, Medawar PB (1953) Activity acquired tolerance of foreign cells. Nature 172:603–606

    Article  PubMed  CAS  Google Scholar 

  • Bohring C, Krause W (2001) Differences in the antigen pattern recognized by antisperm antibodies in patients with infertility and vasectomy. J Urol 166:1178–1180

    Article  PubMed  CAS  Google Scholar 

  • Bohring C, Krause W (2003) Immune infertility: towards a better understanding of sperm (auto)-immunity: the value of proteomic analysis. Hum Reprod 18:915–924

    Article  PubMed  CAS  Google Scholar 

  • Bronson R (1999a) Detection of antisperm antibodies: an argument against therapeutic nihilism. Hum Reprod 14:1671–1673

    Article  PubMed  CAS  Google Scholar 

  • Bronson RA (1999b) Antisperm antibodies: a critical evaluation and clinical guidelines. J Reprod Immunol 45:159–183

    Article  PubMed  CAS  Google Scholar 

  • Bronson R, Cooper G, Rosenfeld D (1984) Sperm antibodies: their role in infertility. Fertil Steril 42:171–183

    PubMed  CAS  Google Scholar 

  • Burkman LJ, Coddington CC, Franken DR, Krugen TF, Rosenwaks Z, Hogen GD(1988) The hemizona assay (HZA): development of a diagnostic test for the binding of human spermatozoa to the human hemizona pellucida to predict fertilization potential. Fertil Steril 49:688–697

    PubMed  CAS  Google Scholar 

  • Carlsson L, Nilsson BO, Ronquist G, Lundquist M, Larsson A (2004) A new test for immunological infertility: an ELISA based on prostasomes. Int J Androl 27:130–133

    Article  PubMed  CAS  Google Scholar 

  • Check JH, Hourani W, Check ML, Graziano V, Levin E (2004) Effect of treating antibody-coated sperm with chymotrypsin on pregnancy rates following IUI as compared to outcome of IVF/ICSI. Arch Androl 50:93–95

    Article  PubMed  CAS  Google Scholar 

  • Chiu WW, Chamley LW (2003) Human seminal plasma antibody-binding proteins. Am J Reprod Immunol 50:196–201

    Article  PubMed  CAS  Google Scholar 

  • Clarke GN, Elliott PJ, Smaila C (1985a) Detection of sperm antibodies in semen using the immunobead test: a survey of 813 consecutive patients. Am J Reprod Immunol Microbiol 7:118–123

    PubMed  CAS  Google Scholar 

  • Clarke GN, Stojanoff A, Cauchi MN, Johnston WI (1985b) The immunoglobulin class of antispermatozoal antibodies in serum. Am J Reprod Immunol Microbiol 7:143–147

    PubMed  CAS  Google Scholar 

  • Comhaire FH, Hinting A, Vermeulen L, Schoonjans F, Goethals I (1988) Evaluation of the direct and indirect mixed antiglobulin reactionwith latex particles for the diagnosis of immunological infertility. Int J Androl 11:37–44

    PubMed  CAS  Google Scholar 

  • Cross NL, Moore S (1990) Regional binding of human antisperm antibodies assessed by indirect immunofluorescence. Hum Reprod 5:47–51

    PubMed  CAS  Google Scholar 

  • Dym M, Fawcett DW (1970) The blood-testis barrier in the rat and the physiological compartmentation of the seminiferous epithelium. Biol Reprod 3:308–326

    PubMed  CAS  Google Scholar 

  • Eggert-Kruse W, Bockem-Hellwig S, Doll A, Rohr G, Tilgen W, Runnebaum B (1993) Antisperm antibodies in cervical mucus in an unselected subfertile population. Hum Reprod 8:1025–1031

    PubMed  CAS  Google Scholar 

  • El Demiry MI, Hargreave TB, Busuttil A, James K, Ritchie AW, Chisholm GD (1985) Lymphocyte sub-populations in the male genital tract. Br J Urol 57:769–774

    Article  PubMed  Google Scholar 

  • Eliasson R (1977) Supravital staining of human spermatozoa. Fertil Steril 28:1257

    PubMed  CAS  Google Scholar 

  • Friberg J (1974) Asimple and sensitive micro-method for demonstration of sperm-agglutinating activity in serum from infertile men and women. Acta Obstet Gynecol Scand Suppl 21–29

    Google Scholar 

  • Friberg J (1980) Immunoglobulin concentration in serum and seminal fluid frommen with and without sperm-agglutinating antibodies. Am J Obstet Gynecol 136:671–675

    PubMed  CAS  Google Scholar 

  • Grigoriou O, Konidaris S, Antonaki V, Papadias C, Antoniou G, Gargaropoulos A (1996) Corticosteroid treatment does not improve the results of intrauterine insemination in male subfertility caused by antisperm antibodies. Eur J Obstet Gynecol Reprod Biol 65:227–230

    Article  PubMed  CAS  Google Scholar 

  • Haas GG Jr (1987) Antibody-mediated causes of male infertility. Urol Clin North Am 14:539–550

    PubMed  Google Scholar 

  • Haas GG Jr (1991) Male fertility and immunity. In: Lipshultz LI, Howards SS (eds) Infertility in the male, Mosby-Year Book, St.Louis, pp 277–296

    Google Scholar 

  • Haas GG Jr, Cines DB, Schreiber AD(1980) Immunologic infertility: identification of patients with antisperm antibody. N Engl J Med 303:722–727

    Article  PubMed  Google Scholar 

  • Hancock RJ, Faruki S (1984) Detection of antibody-coated sperm by ‘panning’ procedures. J Immunol Methods 66:149–159

    Article  PubMed  CAS  Google Scholar 

  • Hendry WF (1989) Detection and treatment of antispermatozoal antibodies in men. Reprod Fertil Dev 1:205–220

    Article  PubMed  CAS  Google Scholar 

  • Hinting A, Vermeulen L, Comhaire F (1988a) Evaluation of a simplified adenosine triphosphate release cytotoxicity test for the detection of sperm antibodies in human serum. J Reprod Immunol 13:123–131

    Article  PubMed  CAS  Google Scholar 

  • Hinting A, Vermeulen L, Comhaire F (1988b) The indirect mixed antiglobulin reaction test using a commercially available kit for the detection of antisperm antibodies in serum. Fertil Steril 49:1039–1044

    PubMed  CAS  Google Scholar 

  • Hinting A, Vermeulen L, Goethals I, Dhont M, Comhaire F (1989) Effect of different procedures of semen preparation on antibody-coated spermatozoa and immunological infertility. Fertil Steril 52:1022–1026

    PubMed  CAS  Google Scholar 

  • Hinting A, Soebadi DM, Santoso RI (1996) Evaluation of the immunological cause of male infertility. Andrologia 28:123–126

    Article  PubMed  CAS  Google Scholar 

  • Ingerslev HJ (1981) Antibodies against spermatozoal surface-membrane antigens in female infertility. Acta Obstet Gynecol Scand Suppl 100:1–52

    Article  PubMed  CAS  Google Scholar 

  • Isojima S, Li TS, Ashitaka Y (1968) Immunological analysis of sperm-immobilizing factor found in sera of women with unexplained sterility. Am J Obstet Gynecol 101:677–683

    Google Scholar 

  • Jager S, Kremer J, van Slochteren-Draaisma T (1978) A simple method of screening for antisperm antibodies in the human male. Detection of spermatozoal surface IgG with the direct mixed antiglobulin reaction carried out on untreated fresh human semen. Int J Fertil 23:12–21

    PubMed  CAS  Google Scholar 

  • Jager S, Kremer J, van Slochteren-Draaisma T (1979) Presence of sperm agglutinating antibodies in infertilemen and inhibition of in vitro sperm penetration into cervical mucus. Int J Androl 2:117–130

    Google Scholar 

  • Jones WR (1980) Immunologic infertility-fact or fiction? Fertil Steril 33:577–586

    PubMed  CAS  Google Scholar 

  • Kay DJ, Boettcher B (1992) Comparison of the SpermMar test with currently accepted procedures for detecting human sperm antibodies. Reprod Fertil Dev 4:175–181

    Article  PubMed  CAS  Google Scholar 

  • Kazemeyni SM (2003) Correlation between antisperm antibodies and successful testicular sperm extraction in azoospermic men. Reprod Biomed Online 7[Suppl 1]:30–40

    Google Scholar 

  • Khoo D, Feigenbaum SL, McClure RD (1991) Screening assays for immunologic infertility: a comparison study. Am J Reprod Immunol 26:11–16

    PubMed  CAS  Google Scholar 

  • Kibrick S, Belding DL, Merrill B (1952) Methods for the detection of antibodies against mammalian spermatozoa. II. A gelatin agglutination test. Fertil Steril 3:430–438

    PubMed  CAS  Google Scholar 

  • Knudson G, Ross L, Stuhldreher D, Houlihan D, Bruns E, Prins G (1994) Prevalence of sperm bound antibodies in infertile men with varicocele: the effect of varicocele ligation on antibody levels and semen response. J Urol 151:1260–1262

    PubMed  CAS  Google Scholar 

  • Lahteenmaki A, Veilahti J, Hovatta O (1995) Intra-uterine insemination versus cyclic, low-dose prednisolone in couples with male antisperm antibodies. Hum Reprod 10:142–147

    Article  PubMed  CAS  Google Scholar 

  • Linnet L, Suominen JJ (1982) A comparison of eight techniques for the evaluation of the auto-immune response to spermatozoa after vasectomy. J Reprod Immunol 4:133–144

    Article  PubMed  CAS  Google Scholar 

  • Lombardo F, Gandini L, Dondero F, Lenzi A (2001) Antisperm immunity in natural and assisted reproduction. Hum Reprod Update 7:450–456

    Article  PubMed  CAS  Google Scholar 

  • Mahmoud AM, Tuyttens CL, Comhaire FH (1996) Clinical and biological aspects of male immune infertility: a case-controlled study of 86 cases. Andrologia 28:191–196

    Article  PubMed  CAS  Google Scholar 

  • Marin-Briggiler CI, Vazquez-Levin MH, Gonzalez-Echeverria F, Blaquier JA, Miranda PV, Tezon JG (2003) Effect of antisperm antibodies present in human follicular fluid upon the acrosome reaction and sperm-zona pellucida interaction. Am J Reprod Immunol 50:209–219

    Article  PubMed  Google Scholar 

  • Mazumdar S, Levine AS (1998) Antisperm antibodies: etiology, pathogenesis, diagnosis, and treatment. Fertil Steril 70:799–810

    Article  PubMed  CAS  Google Scholar 

  • Meinertz H, Linnet L, Fogh-Andersen P, Hjort T (1990) Antisperm antibodies and fertility after vasovasostomy: a follow-up study of 216 men. Fertil Steril 54:315–321

    PubMed  CAS  Google Scholar 

  • Mengel W, Zimmermann FA (1982) Immunologic aspects of cryptorchidism. Urol Clin North Am 9:349–352

    PubMed  CAS  Google Scholar 

  • Naz RK (2004) Modalities for treatment of antisperm antibody mediated infertility: novel perspectives. Am J Reprod Immunol 51:390–397

    Article  PubMed  Google Scholar 

  • Podzimek S, Prochazkova J, Pribylova L, Bartova J, Ulcova-Gallova Z, Mrklas L, Stejskal VD (2003) [Effect of heavy metals on immune reactions in patients with infertility]. Cas Lek Cesk 142:285–288

    PubMed  CAS  Google Scholar 

  • Rowe PJ, Comhaire FH, Hargreave TB, Mahmoud AMA (2000) WHO manual for the standardized investigation, diagnosis and management of the infertile male. Cambridge University Press, Cambridge

    Google Scholar 

  • Rumke P (1954) The presence of sperm antibodies in serum of two patients with oligozoospermia. Vox Sang 4:135–140

    Google Scholar 

  • Rumke P (1974) The origin of immunoglobulins in semen. Clin Exp Immunol 17:287–297

    PubMed  CAS  Google Scholar 

  • Shulman JF, Shulman S (1982) Methylprednisolone treatment of immunologic infertility in male. Fertil Steril 38:591–599

    PubMed  CAS  Google Scholar 

  • Sinisi AA, Di Finizio B, Pasquali D, Scurini C, D’Apuzzo A, Bellastella A (1993) Prevalence of antisperm antibodies by SpermMARtest in subjects undergoing a routine sperm analysis for infertility. Int J Androl 16:311–314

    PubMed  CAS  Google Scholar 

  • Snow K, Ball GD (1992) Characterization of human sperm antigens and antisperm antibodies in infertile patients. Fertil Steril 58:1011–1019

    PubMed  CAS  Google Scholar 

  • Steen Y, Forssman L, Lonnerstedt E, Jonasson K, Wassen AC, Lycke E (1994) Anti-sperm IgA antibodies against the equatorial segment of the human spermatozoon are associated with impaired sperm penetration and subfertility. Int J Fertil Menopausal Stud 39:52–56

    PubMed  CAS  Google Scholar 

  • Talbot P, Chacon RS (1981) A triple-stain technique for evaluating normal acrosome reactions of human sperm. J Exp Zool 215:201–208

    Article  PubMed  CAS  Google Scholar 

  • Tauber PF, Zaneveld LJ, Propping D, Schumacher GF (1975) Components of human split ejaculates. I. Spermatozoa, fructose, immunoglobulins, albumin, lactoferrin, transferrin and other plasma proteins. J Reprod Fertil 43:249–267

    Article  PubMed  CAS  Google Scholar 

  • Tung KSK (1980) Autoimmunity of the testis. In: Dhindsa DS, Schumacher GFB (eds) Immunological aspects of infertility and fertility regulation, Elsevier-North Holland, New York, pp 33–91

    Google Scholar 

  • Vermeulen A, Comhaire F (1983) Le test “MAR” aux particules de Latex, et le test spermatoxique selon Suominen: simplification et nouveautée dans l’arsenal du diagnostic immunologique. Contraception, Fertilitée, Sexualitée 11:381–384

    Google Scholar 

  • Wen RQ, Li SQ, Wang CX, Wang QH, Li QK, Feng HM, Jiang YJ, Huang JC (1994) Analysis of spermatozoa from the proximal vas deferens of vasectomized men. Int J Androl 17:181–185

    PubMed  CAS  Google Scholar 

  • WHO (1987) Towards more objectivity in diagnosis and management of male infertility. Int J Androl Suppl 7

    Google Scholar 

  • WHO (1999) WHO laboratory manual of the examination of human semen and sperm-cervical mucus interaction. Cambridge University Press, Cambridge

    Google Scholar 

  • Wilson L (1954) Sperm agglutinins in human semen and blood. Proc Soc Exp Biol Med 85:652–655

    PubMed  CAS  Google Scholar 

  • Witkin SS (1988) Mechanisms of active suppression of the immune response to spermatozoa. AmJ Reprod Immunol Microbiol 17:61–64

    CAS  Google Scholar 

  • Yanagimachi R, Yanagimachi H, Rogers BJ (1976) The use of zona-free animal ova as a test-system for the assessment of the fertilizing capacity of human spermatozoa. Biol Reprod 15:471–476

    Article  PubMed  CAS  Google Scholar 

  • Yeh WR, Acosta AA, Seltman HJ, Doncel G (1995) Impact of immunoglobulin isotype and sperm surface location of antisperm antibodies on fertilization in vitro in the human. Fertil Steril 63:1287–1292

    PubMed  CAS  Google Scholar 

  • Zalata A, Hafez T, Comhaire F (1995) Evaluation of the role of reactive oxygen species in male infertility. Hum Reprod 10:1444–1451

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Center for Medical and Urological Andrology and Reproductive Endocrinology, University Hospital Ghent 6K12IE, De Pintelaan 185, 9000, Ghent, Belgium

    A. Mahmoud & F. Comhaire

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  1. A. Mahmoud
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  2. F. Comhaire
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Editors and Affiliations

  1. Center of Dermatology and Andrology, Justus Liebig University Giessen, Gaffystraße 14, 35385, Giessen, Germany

    Wolf-Bernhard Schill

  2. Center for Medical and Urological Andrology and Reproductive Endocrinology, University Hospital Ghent 6K12IE, De Pintelaan 185, 9000, Ghent, Belgium

    Frank Comhaire

  3. Department of Oncology, University of Edinburgh, Western General Hospital, Human Genetics Building, Edinburgh, EH4 2XU, Scotland UK

    Timothy B. Hargreave

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Mahmoud, A., Comhaire, F. (2006). Immunological Causes. In: Schill, WB., Comhaire, F., Hargreave, T.B. (eds) Andrology for the Clinician. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-33713-X_16

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  • DOI: https://doi.org/10.1007/3-540-33713-X_16

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