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Yearbook of Intensive Care and Emergency Medicine pp 45–51Cite as

The Role of Extracellular Heat Shock Proteins in Cellular Inflammation and Injury

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Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2006))

Conclusions

The heat shock, or stress response is an ancient, highly conserved, primitive endogenous cellular defense mechanism. Traditionally, stress proteins, e.g. HSP70, have been considered to be exclusively intracellular proteins. However, increasing evidence supports a role for extracellular stress proteins, including HSP70, in the innate and acquired immune response. For example, stress proteins have been reported to stimulate the immune system via innate receptors, such as the TLR. Recent data, however, challenge this notion by claiming that it is the bacterial molecules that are trapped by the stress proteins, and not the stress proteins themselves that activate the immune system. In this brief review, we have presented evidence to suggest that stress proteins are indeed modulators of immune function. Whether activation of the immune response by extracellular stress proteins such as HSP70 serves a cytoprotective function, a pro-inflammatory function, or both, depending on context, remains to be determined.

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Authors and Affiliations

  1. Division of Critical Care Medicine, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229-3039, USA

    D. S. Wheeler, B. Zingarelli & H. R. Wong

Authors
  1. D. S. Wheeler
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  2. B. Zingarelli
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  3. H. R. Wong
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head) (Head)

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Wheeler, D.S., Zingarelli, B., Wong, H.R. (2006). The Role of Extracellular Heat Shock Proteins in Cellular Inflammation and Injury. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2006. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-33396-7_5

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  • DOI: https://doi.org/10.1007/3-540-33396-7_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-30155-4

  • Online ISBN: 978-3-540-33396-8

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