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The Importance of T Cell Interactions with Macrophages in Rheumatoid Cytokine Production

  • Chapter
Current Concepts in Autoimmunity and Chronic Inflammation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 305))

Abstract

The analysis of suppression of cytokines in rheumatoid synovial tissue and fluid pioneered the studies of human cytokines in diseased tissue due to the relative ease of staining samples, even at the height of the inflammatory process. These studies led to the study of synovial cytokine regulation, and the identification of TNF as a therapeutic target, which has been amply validated in clinical trials and now routine therapy. The next key question was how is TNF disregulated in synovium. Are there differences between the mechanisms of synovial TNF production compared to the production of protective TNF during an immune response? Are there differences between the induction of the pro-inflammatory TNF and the anti inflammatory IL-10? The analysis of the interaction of the twomost abundant synovial cells, T lymphocytes andmacrophages has provided interesting clues to new therapeutic approaches based on disrupting T-macrophage interaction.

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Authors and Affiliations

  1. Technology and Medicine, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, 1 Aspenlea Road, London, W6 8LH, UK

    F. M. Brennan & M. Feldmann

  2. School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UK

    A. D. Foey

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  1. F. M. Brennan
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  2. A. D. Foey
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  3. M. Feldmann
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Editors and Affiliations

  1. Deutsches Rheumaforschungszentrum Berlin (DRFZ), Schumannstr.21/22, 10117, Berlin, Germany

    Andreas Radbruch Ph.D.

  2. National Institute of Arthritis and Musculoskeletal and Skin Diseases, 9000 Rockville Pike, Bethesda, MD, 20892-1560, USA

    Peter E. Lipsky MD

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Brennan, F.M., Foey, A.D., Feldmann, M. (2006). The Importance of T Cell Interactions with Macrophages in Rheumatoid Cytokine Production. In: Radbruch, A., Lipsky, P.E. (eds) Current Concepts in Autoimmunity and Chronic Inflammation. Current Topics in Microbiology and Immunology, vol 305. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29714-6_9

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