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Naturally Arising Foxp3-Expressing CD25+CD4+ Regulatory T Cells in Self-Tolerance and Autoimmune Disease

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Current Concepts in Autoimmunity and Chronic Inflammation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 305))

Abstract

Naturally arising CD25+CD4+ regulatory T cells, which express the transcription factor Foxp3, play key roles in themaintenance of immunologic self-tolerance and negative control of a variety of physiological and pathological immune responses. The majority of them are produced by the normal thymus as a functionally mature T cell subpopulation specialized for suppressive function. Their generation is in part genetically and developmentally controlled. Genetically determined or environmentally induced abnormality in CD25+CD4+ regulatory T cell development, maintenance, and function can be a cause of autoimmune disease in humans.

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Authors and Affiliations

  1. Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan

    S. Sakaguchi, R. Setoguchi, H. Yagi & T. Nomura

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  1. S. Sakaguchi
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  2. R. Setoguchi
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  3. H. Yagi
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  4. T. Nomura
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Editors and Affiliations

  1. Deutsches Rheumaforschungszentrum Berlin (DRFZ), Schumannstr.21/22, 10117, Berlin, Germany

    Andreas Radbruch Ph.D.

  2. National Institute of Arthritis and Musculoskeletal and Skin Diseases, 9000 Rockville Pike, Bethesda, MD, 20892-1560, USA

    Peter E. Lipsky MD

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Sakaguchi, S., Setoguchi, R., Yagi, H., Nomura, T. (2006). Naturally Arising Foxp3-Expressing CD25+CD4+ Regulatory T Cells in Self-Tolerance and Autoimmune Disease. In: Radbruch, A., Lipsky, P.E. (eds) Current Concepts in Autoimmunity and Chronic Inflammation. Current Topics in Microbiology and Immunology, vol 305. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29714-6_3

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