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References
Backhof E, Heijboer RJJ, Algra PR (1992) Inadvertent iv administration of gadopentetate dimeglumine during early pregnancy. AJR Am J Roentgenol 158:1171
Bloomfield TH, Hawkins DF (1991) The effects of drugs on the human fetus. In: Philipp E, Setchell M (eds) Scientific foundations of obstetrics and gynaecology, 4th edn. Butterworth-Heinemann, Oxford, p 320
Blumberg ML, Wohl GT, Wiltchik S, Schwarz R, Emich JP (1967) Placental localisation by amniography. AJR Am J Roentgenol 100:688–697
Bona G, Zaffaroni M, Defilippe C, Gallina MR, Mostert M (1992) Effects of iopamidol on neonatal thyroid function. Eur J Radiol 14:22–25
Bourrinet P, Dencausse A, Havard P, Violas X, Bonnemain B (1995) Transplacental passage and milk excretion of iobitridol. Invest Radiol 30:156–158
Bourrinet P, Dencausse A, Cochet P, Chastin I, Bonnemain B (1997) Secretion in milk and transplacental transfer of two iodised oils, Lipiodol UF and Oriodol, in rabbits. Biol Neonate 71:395–402
Broughton-Pipkin F, Hull D, Stephenson T (1994) Foetal physiology. In: Lamming GE (ed) Marshall’s physiology of reproduction, 4th edn. Chapman and Hall, London, p 777
Bury RF (2002) Radiation hazards in urological practice. BJU Int 89:505–509
Cacheris WP, Quay SC, Rocklage SM (1990) The relationship between thermodynamics and the toxicity of gadolinium complexes. Magn Reson Imaging 8:467–481
Cochran ST, Norman A (1994) Induction of micronuclei in lymphocytes of patients undergoing excretory urography with ioversol. Invest Radiol 29:210–212
Cochran ST, Khodadoust A, Norman A (1980) Cytogenetic effects of contrast material in patients undergoing excretory urography. Radiology 136:43–46
Delange F, de Benoist B, Pretell B, Dunn JT (2001) Iodine deficiency in the world: where do we stand at the turn of the century? Thyroid 11:437–447
Donandieu AM, Idee JM, Doncet D et al (1996) Toxicologic profile of iobitridol, a new nonionic low osmolality contrast medium. Acta Radiol [Suppl] 400:17–24
Etling N, Gehin-Fouque F, Vielh JP, Gautray JP (1979) The iodine content of amniotic fluid and placental transfer of iodinated drugs. Obstet Gynecol 53:376–380
Felder E (1984) Iopamidol toxicology. Invest Radiol 19[Suppl]: S168–S170
Fitzjohn TP, Williams DG, Laker MF, Owen JP (1982) Intravenous urography during lactation. Br J Radiol 55:603–605
Fujikawa K, Sakaguchi Y, Harada S, Holtz, E, Smith JA, Svendson O (1995) Reproductive toxicity of iodixanol, a new non-ionic, iso-tonic contrast medium in rats and rabbits (in Japanese). J Toxicol Sci 20[Suppl 1]:107–115
Heglund IF, Michelet AA, Blazak WF, Furuhama K, Holtz E (1995) Preclinical pharmacokinetics and general toxicity of iodixanol. Acta Radiol [Suppl] 399:69–82
Holmdahl KH (1956) Cholecystography during lactation. Acta Radiol 45:305–307
Ilett KF, Hackett LP, Paterson JW, McCormick CC (1981) Excretion of metrizamide in milk. Br J Radiol 54:537–538
Johansen JG (1978) Assessment of a non-ionic contrast medium (Amipaque) in the gastrointestinal tract. Invest Radiol 13:523–527
Jorulf H (1983) Iohexol compared with diatrizoate in pediatric urography. Acta Radiol [Suppl] 366:42–45
Kelleher J, Feczko PJ, Radkowski MA, Griscom NT (1979) Neonatal intestinal opacification secondary to transplacental passage of urographic contrast medium. AJR Am J Roentgenol 132:63–65
Klein RZ, Mitchell ML (2000) Hypothyroidism in infants and children. In: Braverman LE, Utiger RD (eds) The thyroid: a fundamental and clinical text, 8th edn. Lippincott, Williams and Wilkins, Philadelphia, pp 973–974
Krause W, Schobel C, Press WR (1994) Preclinical testing of iopromide. 2nd communication: toxicological evaluation. Arzneimittelforschung 44:1275–1279
Kubik-Huch RA, Gottstein Alama NM, Frenzel T et al (2000) Gadopentetate dimeglumine excretion into human breast milk during lactation. Radiol 216:555–558
Laniado M, Kornmesser W, Hamm B, Clauss W, Weinmann H-J, Felix R (1988) MR imaging of the gastrointestinal tract: value of Gd-DTPA. AJR Am J Roentgenol 150:817–821
Leverge R, Bergmann JF, Simoneau G, Tillet Y, Bonnemain B (2003) Bioavailability of oral vs intramuscular iodinated oil (Lipiodol UF) in healthy subjects. J Endocrinol Invest 26[Suppl 2]:2–6
Marcos HB, Semelka RC, Worowattanakul S (1997) Normal placenta: gadolinium-enhanced dynamic MR imaging. Radiology 205:493–496
Marti-Bonmati L, Vega T, Benito C et al (2000) Safety and efficacy of Omniscan (gadodimide injection) at 0.1 mmol/kg for MRI in infants younger than 6 months of age: phase III open multicenter study. Invest Radiol 35:141–147
Moon AJ, Katzberg RW, Sherman MP (2000) Transplacental passage of iohexol. J Pediatr 136:548–549
Morisetti A, Tirone P, Luzzani F, de Haen C (1994) Toxicological safety assessment of iomeprol, a new x-ray contrast agent. Eur J Radiol 18[Suppl 1]:S21–S31
Morisetti A, Bussi S, Tirone P, de Haen C (1999) Toxicological safety evaluation of gadobenate dimeglumine 0.5 M solution for injection (Multihance), a new magnetic resonance imaging contrast medium. J Comput Assist Tomogr 23[Suppl 1]:S207–S217
Morrison JC, Boyd M, Friedman BI et al (1973) The effects of Renografin-60 on the fetal thyroid. Obstet Gynecol 42:99–103
Nelson JA, Livingstone GK, Moon RG (1982) Mutagenic evaluation of radiographic contrast media. Invest Radiol 17:183–185
Nielsen ST, Matheson I, Rasmussen JN, Skinnemoen K, Andrew E, Hafsahl G (1987) Excretion of iohexol and metrizoate in human breast milk. Acta Radiol 28:523–526
Norman A, Adams FH, Riley RF (1978) Cytogenetic effects of contrast media and tri-iodobenzoic acid derivatives in human lymphocytes. Radiology 129:199–203
Norman A, Cochran ST, Sayre JW (2001) Meta-analysis of increases in micronuclei in peripheral blood lymphocytes after angiography or excretory urography. Radiat Res 15:740–743
Normann PT, Joffe P, Martinsen I, Thomsen HS (2000) Identification and quantification of gadodiamide in serum, peritoneal dialysate and faeces from end-stage renal patients dosed with gadodiamide injection by inductively coupled plasma-atomic emission spectroscopy and comparative analysis by high-performance liquid chromatography. J Pharm Biomed Anal 22:939–947
Novak Z, Thurmond A, Ross PL, Jones MK, Thornburg KI, Katzberg RW (1993) Gadolinium-DTPA transplacental transfer and distribution in fetal tissue in rabbits. Invest Radiol 28:828–830
Okazaki O, Murayama N, Masubuchi N, Nomura H, Hakasui H (1996) Placental transfer and milk secretion of gadodiamide injection in rats. Arzneimittelforschung/Drug Res 46:83–86
Ralston WH, Robbins MS, James P (1989) Reproductive, developmental and genetic toxicity of ioversol. Invest Radiol 24[Suppl 1]:S16–S22
Ramsay I (1986) The thyroid. In: Philipp EE, Barnes J, Newton M (eds) Scientific foundation of obstetrics and gynaecology, 3rd edn. Heinemann, London, p 463
Raphael MJ, Gordon H, Schiff D (1967) Radiological aspects of intra-uterine blood transfusion. Br J Radiol 40:520–527
Rodesch F, Camus M, Ermans AM, Dodion J, Delange F (1976) Adverse effect of amniofetography on fetal thyroid function. Am J Obstet Gynecol 126:723–726
Rofsky NM, Weinreb JC, Litt AW (1993) Quantitative analysis of gadopentetate dimeglumine excreted in breast milk. J Magn Reson Imaging 3:131–132
Rofsky NM, Pizzarello DJ, Weinreb JC, Ambrosino MM, Rosenberg C (1994) Effect on fetal mouse development of exposure to MR imaging and gadopentetate dimeglumine. J Magn Reson Imaging 4:805–807
Rofsky NM, Pizzarello DJ, Duhaney MO, Falick AK, Prendergast N, Weinreb JC (1995) Effect of magnetic resonance exposure combined with gadopentetate dimeglumine on chromosomes in animal specimens. Acad Radiol 2:492–496
Schmiedl U, Maravilla KR, Gerlach R, Dowling CA (1990) Excretion of gadopentetate dimeglumine in human breast milk. AJR Am J Roentgenol 154:1305–1306
Semba RD, Delange F (2001) Iodine in human milk: perspectives for infant health. Nutr Rev 59:269–278
Shaw DD, Potts DG (1985) Toxicology of iohexol. Invest Radiol [Suppl 1]:S10–S13
Shoenut JP, Semelka RC, Silverman R, Yaffe CS, Micflikier AB (1993) MRI in the diagnosis of Crohn’s disease in two pregnant women. J Clin Gastroenterol 17:244–247
Soltys RA (1992) Summary of preclinical safety evaluation of gadoteridol injection. Invest Radiol 27[Suppl 1]:S7–S11
Spencer JA, Tomlinson AJ, Weston MJ, Lloyd SN (2000) Early report: comparison of breath-hold MR excretory urography. Doppler ultrasound and isotope renography in evaluation of symptomatic hydronephrosis in pregnancy. Clin Radiol 55:446–453
Stubbe P, Heidermann P, Schumbraad P, Ulbrich R (1980) Transient congenital hypothyroidism after amniofetography. Eur J Pediatr 135:97–99
Thomas CR, Lang EK, Lloyd FP (1963) Fetal pyelography — a method for detecting fetal life. Obstet Gynecol 22:335–340
Tsai-Goodman B, Geva T, Odegard KC, Sena LM, Powell AJ (2004) Clinical role, accuracy and technical aspects of cardiovascular magnetic resonance imaging in infants. Am J Cardiol 94:69–74
Tweedle MF, Wedeking P, Kumar K (1995) Biodistribution of radiolabelled, formulated gadopentate, gadoteridol, gadoterate and gadodiamide in mice and rats. Invest Radiol 30:372–380
Van der Molen AJ, Thomsen HS, Morcos SK, members of Contrast Media Safety Committee of European Society of Urogenital Radiology (2004) Effect of iodinated contrast media on thyroid function in adults. Eur Radiol 14:902–907
Wholey MH (1967) Evaluation of arteriography in obstetrics. Radiol Clin North Am 5:121–131
Wible JH Jr, Troup CM, Hynes MR et al (2001) Toxicological assessment of gadoversetamide injection (OPTIMARK), a new contrast-enhancement agent for use in magnetic resonance imaging. Invest Radiol 36:401–412
Wilson JT, Brown RR, Cherek DR et al (1980) Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin Pharmacokinet 5:1–66
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Webb, J.A.W. (2006). Iodinated and Gadolinium Contrast Media During Pregnancy and Lactation. In: Thomsen, H.S. (eds) Contrast Media. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27742-0_9
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