Skip to main content

Iodinated and Gadolinium Contrast Media During Pregnancy and Lactation

  • Chapter

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Backhof E, Heijboer RJJ, Algra PR (1992) Inadvertent iv administration of gadopentetate dimeglumine during early pregnancy. AJR Am J Roentgenol 158:1171

    Google Scholar 

  • Bloomfield TH, Hawkins DF (1991) The effects of drugs on the human fetus. In: Philipp E, Setchell M (eds) Scientific foundations of obstetrics and gynaecology, 4th edn. Butterworth-Heinemann, Oxford, p 320

    Google Scholar 

  • Blumberg ML, Wohl GT, Wiltchik S, Schwarz R, Emich JP (1967) Placental localisation by amniography. AJR Am J Roentgenol 100:688–697

    CAS  Google Scholar 

  • Bona G, Zaffaroni M, Defilippe C, Gallina MR, Mostert M (1992) Effects of iopamidol on neonatal thyroid function. Eur J Radiol 14:22–25

    Article  CAS  PubMed  Google Scholar 

  • Bourrinet P, Dencausse A, Havard P, Violas X, Bonnemain B (1995) Transplacental passage and milk excretion of iobitridol. Invest Radiol 30:156–158

    CAS  PubMed  Google Scholar 

  • Bourrinet P, Dencausse A, Cochet P, Chastin I, Bonnemain B (1997) Secretion in milk and transplacental transfer of two iodised oils, Lipiodol UF and Oriodol, in rabbits. Biol Neonate 71:395–402

    CAS  PubMed  Google Scholar 

  • Broughton-Pipkin F, Hull D, Stephenson T (1994) Foetal physiology. In: Lamming GE (ed) Marshall’s physiology of reproduction, 4th edn. Chapman and Hall, London, p 777

    Google Scholar 

  • Bury RF (2002) Radiation hazards in urological practice. BJU Int 89:505–509

    Article  CAS  PubMed  Google Scholar 

  • Cacheris WP, Quay SC, Rocklage SM (1990) The relationship between thermodynamics and the toxicity of gadolinium complexes. Magn Reson Imaging 8:467–481

    CAS  PubMed  Google Scholar 

  • Cochran ST, Norman A (1994) Induction of micronuclei in lymphocytes of patients undergoing excretory urography with ioversol. Invest Radiol 29:210–212

    CAS  PubMed  Google Scholar 

  • Cochran ST, Khodadoust A, Norman A (1980) Cytogenetic effects of contrast material in patients undergoing excretory urography. Radiology 136:43–46

    CAS  PubMed  Google Scholar 

  • Delange F, de Benoist B, Pretell B, Dunn JT (2001) Iodine deficiency in the world: where do we stand at the turn of the century? Thyroid 11:437–447

    Article  CAS  PubMed  Google Scholar 

  • Donandieu AM, Idee JM, Doncet D et al (1996) Toxicologic profile of iobitridol, a new nonionic low osmolality contrast medium. Acta Radiol [Suppl] 400:17–24

    CAS  Google Scholar 

  • Etling N, Gehin-Fouque F, Vielh JP, Gautray JP (1979) The iodine content of amniotic fluid and placental transfer of iodinated drugs. Obstet Gynecol 53:376–380

    CAS  PubMed  Google Scholar 

  • Felder E (1984) Iopamidol toxicology. Invest Radiol 19[Suppl]: S168–S170

    Google Scholar 

  • Fitzjohn TP, Williams DG, Laker MF, Owen JP (1982) Intravenous urography during lactation. Br J Radiol 55:603–605

    CAS  PubMed  Google Scholar 

  • Fujikawa K, Sakaguchi Y, Harada S, Holtz, E, Smith JA, Svendson O (1995) Reproductive toxicity of iodixanol, a new non-ionic, iso-tonic contrast medium in rats and rabbits (in Japanese). J Toxicol Sci 20[Suppl 1]:107–115

    PubMed  Google Scholar 

  • Heglund IF, Michelet AA, Blazak WF, Furuhama K, Holtz E (1995) Preclinical pharmacokinetics and general toxicity of iodixanol. Acta Radiol [Suppl] 399:69–82

    CAS  Google Scholar 

  • Holmdahl KH (1956) Cholecystography during lactation. Acta Radiol 45:305–307

    CAS  PubMed  Google Scholar 

  • Ilett KF, Hackett LP, Paterson JW, McCormick CC (1981) Excretion of metrizamide in milk. Br J Radiol 54:537–538

    CAS  PubMed  Google Scholar 

  • Johansen JG (1978) Assessment of a non-ionic contrast medium (Amipaque) in the gastrointestinal tract. Invest Radiol 13:523–527

    CAS  PubMed  Google Scholar 

  • Jorulf H (1983) Iohexol compared with diatrizoate in pediatric urography. Acta Radiol [Suppl] 366:42–45

    CAS  Google Scholar 

  • Kelleher J, Feczko PJ, Radkowski MA, Griscom NT (1979) Neonatal intestinal opacification secondary to transplacental passage of urographic contrast medium. AJR Am J Roentgenol 132:63–65

    CAS  PubMed  Google Scholar 

  • Klein RZ, Mitchell ML (2000) Hypothyroidism in infants and children. In: Braverman LE, Utiger RD (eds) The thyroid: a fundamental and clinical text, 8th edn. Lippincott, Williams and Wilkins, Philadelphia, pp 973–974

    Google Scholar 

  • Krause W, Schobel C, Press WR (1994) Preclinical testing of iopromide. 2nd communication: toxicological evaluation. Arzneimittelforschung 44:1275–1279

    CAS  PubMed  Google Scholar 

  • Kubik-Huch RA, Gottstein Alama NM, Frenzel T et al (2000) Gadopentetate dimeglumine excretion into human breast milk during lactation. Radiol 216:555–558

    CAS  Google Scholar 

  • Laniado M, Kornmesser W, Hamm B, Clauss W, Weinmann H-J, Felix R (1988) MR imaging of the gastrointestinal tract: value of Gd-DTPA. AJR Am J Roentgenol 150:817–821

    CAS  PubMed  Google Scholar 

  • Leverge R, Bergmann JF, Simoneau G, Tillet Y, Bonnemain B (2003) Bioavailability of oral vs intramuscular iodinated oil (Lipiodol UF) in healthy subjects. J Endocrinol Invest 26[Suppl 2]:2–6

    Google Scholar 

  • Marcos HB, Semelka RC, Worowattanakul S (1997) Normal placenta: gadolinium-enhanced dynamic MR imaging. Radiology 205:493–496

    CAS  PubMed  Google Scholar 

  • Marti-Bonmati L, Vega T, Benito C et al (2000) Safety and efficacy of Omniscan (gadodimide injection) at 0.1 mmol/kg for MRI in infants younger than 6 months of age: phase III open multicenter study. Invest Radiol 35:141–147

    Article  CAS  PubMed  Google Scholar 

  • Moon AJ, Katzberg RW, Sherman MP (2000) Transplacental passage of iohexol. J Pediatr 136:548–549

    CAS  PubMed  Google Scholar 

  • Morisetti A, Tirone P, Luzzani F, de Haen C (1994) Toxicological safety assessment of iomeprol, a new x-ray contrast agent. Eur J Radiol 18[Suppl 1]:S21–S31

    PubMed  Google Scholar 

  • Morisetti A, Bussi S, Tirone P, de Haen C (1999) Toxicological safety evaluation of gadobenate dimeglumine 0.5 M solution for injection (Multihance), a new magnetic resonance imaging contrast medium. J Comput Assist Tomogr 23[Suppl 1]:S207–S217

    PubMed  Google Scholar 

  • Morrison JC, Boyd M, Friedman BI et al (1973) The effects of Renografin-60 on the fetal thyroid. Obstet Gynecol 42:99–103

    CAS  PubMed  Google Scholar 

  • Nelson JA, Livingstone GK, Moon RG (1982) Mutagenic evaluation of radiographic contrast media. Invest Radiol 17:183–185

    CAS  PubMed  Google Scholar 

  • Nielsen ST, Matheson I, Rasmussen JN, Skinnemoen K, Andrew E, Hafsahl G (1987) Excretion of iohexol and metrizoate in human breast milk. Acta Radiol 28:523–526

    CAS  PubMed  Google Scholar 

  • Norman A, Adams FH, Riley RF (1978) Cytogenetic effects of contrast media and tri-iodobenzoic acid derivatives in human lymphocytes. Radiology 129:199–203

    CAS  PubMed  Google Scholar 

  • Norman A, Cochran ST, Sayre JW (2001) Meta-analysis of increases in micronuclei in peripheral blood lymphocytes after angiography or excretory urography. Radiat Res 15:740–743

    Google Scholar 

  • Normann PT, Joffe P, Martinsen I, Thomsen HS (2000) Identification and quantification of gadodiamide in serum, peritoneal dialysate and faeces from end-stage renal patients dosed with gadodiamide injection by inductively coupled plasma-atomic emission spectroscopy and comparative analysis by high-performance liquid chromatography. J Pharm Biomed Anal 22:939–947

    Article  CAS  Google Scholar 

  • Novak Z, Thurmond A, Ross PL, Jones MK, Thornburg KI, Katzberg RW (1993) Gadolinium-DTPA transplacental transfer and distribution in fetal tissue in rabbits. Invest Radiol 28:828–830

    CAS  PubMed  Google Scholar 

  • Okazaki O, Murayama N, Masubuchi N, Nomura H, Hakasui H (1996) Placental transfer and milk secretion of gadodiamide injection in rats. Arzneimittelforschung/Drug Res 46:83–86

    CAS  Google Scholar 

  • Ralston WH, Robbins MS, James P (1989) Reproductive, developmental and genetic toxicity of ioversol. Invest Radiol 24[Suppl 1]:S16–S22

    CAS  PubMed  Google Scholar 

  • Ramsay I (1986) The thyroid. In: Philipp EE, Barnes J, Newton M (eds) Scientific foundation of obstetrics and gynaecology, 3rd edn. Heinemann, London, p 463

    Google Scholar 

  • Raphael MJ, Gordon H, Schiff D (1967) Radiological aspects of intra-uterine blood transfusion. Br J Radiol 40:520–527

    CAS  PubMed  Google Scholar 

  • Rodesch F, Camus M, Ermans AM, Dodion J, Delange F (1976) Adverse effect of amniofetography on fetal thyroid function. Am J Obstet Gynecol 126:723–726

    CAS  PubMed  Google Scholar 

  • Rofsky NM, Weinreb JC, Litt AW (1993) Quantitative analysis of gadopentetate dimeglumine excreted in breast milk. J Magn Reson Imaging 3:131–132

    CAS  PubMed  Google Scholar 

  • Rofsky NM, Pizzarello DJ, Weinreb JC, Ambrosino MM, Rosenberg C (1994) Effect on fetal mouse development of exposure to MR imaging and gadopentetate dimeglumine. J Magn Reson Imaging 4:805–807

    CAS  PubMed  Google Scholar 

  • Rofsky NM, Pizzarello DJ, Duhaney MO, Falick AK, Prendergast N, Weinreb JC (1995) Effect of magnetic resonance exposure combined with gadopentetate dimeglumine on chromosomes in animal specimens. Acad Radiol 2:492–496

    Article  CAS  PubMed  Google Scholar 

  • Schmiedl U, Maravilla KR, Gerlach R, Dowling CA (1990) Excretion of gadopentetate dimeglumine in human breast milk. AJR Am J Roentgenol 154:1305–1306

    CAS  PubMed  Google Scholar 

  • Semba RD, Delange F (2001) Iodine in human milk: perspectives for infant health. Nutr Rev 59:269–278

    CAS  PubMed  Google Scholar 

  • Shaw DD, Potts DG (1985) Toxicology of iohexol. Invest Radiol [Suppl 1]:S10–S13

    Google Scholar 

  • Shoenut JP, Semelka RC, Silverman R, Yaffe CS, Micflikier AB (1993) MRI in the diagnosis of Crohn’s disease in two pregnant women. J Clin Gastroenterol 17:244–247

    CAS  PubMed  Google Scholar 

  • Soltys RA (1992) Summary of preclinical safety evaluation of gadoteridol injection. Invest Radiol 27[Suppl 1]:S7–S11

    PubMed  Google Scholar 

  • Spencer JA, Tomlinson AJ, Weston MJ, Lloyd SN (2000) Early report: comparison of breath-hold MR excretory urography. Doppler ultrasound and isotope renography in evaluation of symptomatic hydronephrosis in pregnancy. Clin Radiol 55:446–453

    CAS  PubMed  Google Scholar 

  • Stubbe P, Heidermann P, Schumbraad P, Ulbrich R (1980) Transient congenital hypothyroidism after amniofetography. Eur J Pediatr 135:97–99

    Article  CAS  PubMed  Google Scholar 

  • Thomas CR, Lang EK, Lloyd FP (1963) Fetal pyelography — a method for detecting fetal life. Obstet Gynecol 22:335–340

    CAS  PubMed  Google Scholar 

  • Tsai-Goodman B, Geva T, Odegard KC, Sena LM, Powell AJ (2004) Clinical role, accuracy and technical aspects of cardiovascular magnetic resonance imaging in infants. Am J Cardiol 94:69–74

    PubMed  Google Scholar 

  • Tweedle MF, Wedeking P, Kumar K (1995) Biodistribution of radiolabelled, formulated gadopentate, gadoteridol, gadoterate and gadodiamide in mice and rats. Invest Radiol 30:372–380

    CAS  PubMed  Google Scholar 

  • Van der Molen AJ, Thomsen HS, Morcos SK, members of Contrast Media Safety Committee of European Society of Urogenital Radiology (2004) Effect of iodinated contrast media on thyroid function in adults. Eur Radiol 14:902–907

    PubMed  Google Scholar 

  • Wholey MH (1967) Evaluation of arteriography in obstetrics. Radiol Clin North Am 5:121–131

    CAS  PubMed  Google Scholar 

  • Wible JH Jr, Troup CM, Hynes MR et al (2001) Toxicological assessment of gadoversetamide injection (OPTIMARK), a new contrast-enhancement agent for use in magnetic resonance imaging. Invest Radiol 36:401–412

    Article  CAS  PubMed  Google Scholar 

  • Wilson JT, Brown RR, Cherek DR et al (1980) Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin Pharmacokinet 5:1–66

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Webb, J.A.W. (2006). Iodinated and Gadolinium Contrast Media During Pregnancy and Lactation. In: Thomsen, H.S. (eds) Contrast Media. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27742-0_9

Download citation

  • DOI: https://doi.org/10.1007/3-540-27742-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20448-0

  • Online ISBN: 978-3-540-27742-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics