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Ahrens ET, Laidlaw DH, Readhead C, Brosnan CF, Fraser SE, Jacobs RE (1998) MR microscopy of transgenic mice that spontaneously acquire EAE. Magn Reson Med 40:119
Allen MJ, MacRenaris KW, Venkatasubramanian PN, Meade TJ (2004)Cellular delivery of MRI contrast agents. Chem Biol 11:301–307
Alvord EC Jr, Kies MW, Suckling AJ (1984) Experimental encephalomyelitis: a useful model for multiple sclerosis. Liss, New York
Anderson SA, Shukaliak-Quandt J, Jordan EK, Arbab AS, Martin R, McFarland H, Frank JA (2004) Magnetic resonance imaging of labeled T-cells in a mouse model of multiple sclerosis. Ann Neurol 55:654–659
Arbab AS, Yocum GT, Kalish H, Jordan EK, Anderson SA, Khakoo AY, Read EJ, Frank JA (2004) Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI. Blood 104:1217–1223
Arnold DL (1999) Magnetic resonance spectroscopy: imaging axonal damage in MS. J Neuroimmunol 98:2–6
Artemov D, Mori N, Okollie B, Bhujwalla ZM (2003) MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles. Magn Reson Med 49:403–408
Basser PJ, Pierpaoli C (1996) Microstructural features measured using diffusion tensor imaging. J Magn Reson B 111:209–219
Beckmann N, Falk R, Zurbrugg S, Dawson J, Engelhardt P (2003) Macrophage infiltration into the rat knee detected by MRI in a model of antigen-induced arthritis. Magn Reson Med 49:1047–1055
Bendszus M, Stoll G (2003) Caught in the act: in vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imaging. J Neurosci 23:10892–10896
Bogdanov A Jr, Matuszewski L, Bremer C, Petrovsky A, Weissleder R (2002) Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets. Mol Imaging 1:16–23
Bourekas EC, Christoforidis GA, Abduljalil AM, Kangarlu A, Chakeres DW, Spigos DG, Robitaille PM (1999) High resolution MRI of the deep gray nuclei at 8 tesla. J Comput Assist Tomogr 23:867–874
Bulte JW, Arbab AS, Douglas T, Frank JA (2004) Preparation of magnetically labeled cells for cell tracking by magnetic resonance imaging. Methods Enzymol 386:275–299
Burgess RE, Yu Y, Christoforidis GA, Bourekas EC, Chakeres DW, Spigos D, Kangarlu A, Abduljalil AM, Robitaille PM (1999) Human leptomeningeal and cortical vascular anatomy of the cerebral cortex at 8 Tesla. J Comput Assist Tomogr 23:850–856
Cercignani M, Inglese M, Pagani E, Comi G, Filippi M (2001) Mean diffusivity and fractional anisotropy histograms of patients with multiple sclerosis. AJNR Am J Neuroradiol 22:952–958
Chen CN, Sank VJ, Cohen SM, Hoult DI (1986) The field dependence of NMR imaging. I. Laboratory assessment of signal-to-noise ratio and power deposition. Magn Reson Med 3:722–729
Chronik BA, Alejski A, Rutt BK (2000) Design and fabrication of a three-axis edge ROU head and neck gradient coil. Magn Reson Med 44:955–963
Collins CM, Smith MB (2001) Signal-to-noise ratio and absorbed power as functions of main magnetic field strength, and definition of “90°” RF pulse for the head in the birdcage coil. Magn Reson Med 45:684–691
Corot C, Petry KG, Trivedi R, Saleh A, Jonkmanns C, Le Bas JF, Blezer E, Rausch M, Brochet B, Foster-Gareau P, Baleriaux D, Gaillard S, Dousset V (2004) Macrophage imaging in central nervous system and in carotid atherosclerotic plaque using ultrasmall superparamagnetic iron oxide in magnetic resonance imaging. Invest Radiol 39:619–625
Davie CA, Barker GJ, Thompson AJ, Tofts PS, McDonald WI, Miller DH (1997) 1H magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis, J Neurol Neurosurg Psychiatry 63:736–742
De Laquintane BD, Dousset V, Solanilla A, Petry KG, Ripoche J (2002) Iron particle labeling of haematopoietic progenitor cells: an in vitro study. Biosci Rep 22:549–554
De Stefano N, Narayanan S, Matthews PM, Francis GS, Antel JP, Arnold DL (1999) In vivo evidence for axonal dysfunction remote from focal cerebral demyelination of the type seen in multiple sclerosis. Brain 122:1933–1939
Dousset V, Ballarino L, Delalande C, Coussemacq M, Canioni P, Petry KG, Caille JM (1999) Comparison of ultrasmall particles of iron oxide (USPIO)-enhanced T2-weighted, conventional T2-weighted, and gadolinium-enhanced T1-weighted MR images in rats with experimental autoimmune encephalomyelitis. AJNR Am J Neuroradiol 20:223–227
Duewell S, Wolff SD, Wen H, Balaban RS, Jezzard P (1996) MR imaging contrast in human brain tissue: assessment and optimization at 4 T. Radiology 199:780–786
Filippi, M, Tortorella C, Rovaris M, Bozzali M, Possa F, Sormani M P, Iannucci G, Comi G (2000) Changes in the normal appearing brain tissue and cognitive impairment in multiple sclerosis. J Neurol Neurosurg Psychiatry 68:157–161
Floris S, Blezer EL, Schreibelt G, Dopp E, van der Pol SM, Schadee-Eestermans IL, Nicolay K, Dijkstra CD, de Vries HE (2004) Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study. Brain 127:616–627
Floyd E, McShane TM (2004) Development and use of biomarkers in oncology drug development. Toxicol Pathol 32[Suppl 1]:106–115
Frank JA, Zywicke H, Jordan EK, Mitchell J, Lewis BK, Miller B, Bryant LH Jr, Bulte JWM (2002) Magnetic intracellular labeling of mammalian cells by combining (FDA-approved) superparamagnetic iron oxide MR contrast agents and commonly used transfection agents. Acad Radiol 9[Suppl 2]:S484–S487
Gandhi OP, Hagmann MJ, D’Andrea JA (1979) Partbody and multibody effects on absorption of radio frequency electromagnetic energy by animals and by models of man. Radio Sci 14:15–22
Gillis RJ (2002) In vivo molecular imaging. J Cell Biochem [Suppl] 39:231–238
Glover GH (1999) 3D z-shim method for reduction of susceptibility effects in BOLD fMRI 3D z-shim method for reduction of susceptibility effects in BOLD fMRI. Magn Reson Med 42:290–299
Griswold MA, Jakob PM, Nittka M, Goldfarb JW, Haase A (2000) Partially parallel imaging with localized sensitivities (PILS). Magn Reson Med 44:602–609
Grossman RI, McGowan JC (1998) Perspectives on multiple sclerosis. AJNR Am J Neuroradiol 19:1251–1265
Gutin PH (2002) The potential value of iron oxide nanoparticles in brain tumor treatment. AJNR Am J Neuroradiol 23:505
Hayes CE, Edelstein WA, Schenk JF, Mueller OM, Eash M (1985) An efficient, highly homogeneous radiofrequency coil for whole-body NMR imaging at 1.5T. J Magn Reson 63:622–628
Helms G, Stawiarz L, Kivisakk P, Fredrikson S, Hillert J, Link H (1999) Quantitative proton MRS of cerebral multiple sclerosis lesions: regression analysis of metabolite concentrations. Proceedings of International Society of Magnetic Resonance in Medicine, Philadelphia, p 43
Horsfield MA, Rocca MA, Cercignani M, Filippi M (2000) Activity revealed in MRI of multiple sclerosis without contrast agent — a preliminary report. Magn Reson Imaging 18:139–142
Kangarlu A, Robitaille PM (2000) Biological effects and health implications in magnetic resonance imaging. Concept Magn Reson 12:321–359
Kangarlu A, Abduljalil AM, Norris DG, Schwartzbauer C, Robitaille PM (1999) Human RARE imaging at 8 tesla:RF intense imaging without SAR violation. Magn Reson Mater Phys Biol Med (MAGMA) 9:81–84
Kangarlu A, Rammohan KW, Bourekas EC, Chakeres DW (2002) In-vivo microscopic imaging of multiple sclerosis with high filed MRI. In: Filippi M, Comi G (eds) New frontiers of MR-based techniques in MS. Springer, Berlin Heidelberg New York
Kangarlu A, Rammohan KW, Bourekas EC, RayChaudhry A (2004) Imaging of cortical lesions in multiple sclerosis. Proceedings of 12th Meeting of the International Society of Magnetic Resonance in Medicine, Kyoto
Kawczak JA, Mathisen PM, Drazba JA, Fuss B, Macklin WB, Tuohy VK (1998) Digitized image analysis reveals diffuse abnormalities in normal-appearing white matter during acute experimental autoimmune encephalomyelitis. J Neurosci Res 54:364–372
Kidd D, Barkhof F, McConnell R, Algra PR, Allen IV, Revesz T (1999) Cortical lesions in multiple sclerosis. Brain 122:17–26
Lanens D, Van der Linden A, Gerrits PO, ’s-Gravenmade EJ (1994) In vitro NMR micro imaging of the spinal cord of chronic relapsing EAE rats. Magn Reson Imaging 12:469
Lassmann H, Raine CS, Antel J, Prineas JW (1998) Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna. J Neuroimmunol 86:213–217
Leary SM, Silver NC, Stevenson VL, Barker GJ, Miller DH, Thompson AJ (1999) Magnetization transfer of normal appearing white matter in primary progressive multiple sclerosis. Multiple Sclerosis 5:313–316
Li KC, Bednarski MD (2002) Vascular-targeted molecular imaging using functionalized polymerized vesicles. J Magn Reson Imaging 16:388–393
Luker GD, Sharma V, Pica CM, Dahlheimer JL, Li W, Ochesky J, Ryan CE, Piwnica-Worms H, Piwnica-Worms D (2002) Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci USA 99:6961–6966
Lumsden CE (1970) The neuropathology of multiple sclerosis: multiple sclerosis and other demyelinating diseases. In: Vinken P, Bruyn GW (eds) Handbook of clinical neurology, vol 9. North Holland, Amsterdam, pp 217–309
Moffat BA, Reddy GR, McConville P, Hall DE, Chenevert TL, Kopelman RR, Philbert M, Weissleder R, Rehemtulla A, Ross BD (2003) A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRI. Mol Imaging 2:324–232
Moore A, Basilion J, Chiocca AE, Weissleder R (1998) Measuring transferin receptor gene expression by NMR imaging. Biochim Biophys Acta 1402:239–249
Morawski AM, Winter PM, Crowder KC, Caruthers SD, Fuhrhop RW, Scott MJ, Robertson JD, Abendschein DR, Lanza GM, Wickline SA (2004) Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRI. Magn Reson Med 51:480–486
Norris DG, Kangarlu A, Abduljalil A, Schwartzbauer C, Robitaille PM (1999) Human MDEFT imaging at 8 tesla. Magn Reson Mater Phys Biol Med (MAGMA) 9:92–96
Oweida AJ, Dunn EA, Foster PJ (2004) Cellular imaging at 1.5 T: detecting cells in neuroinflammation using active labeling with superparamagnetic iron oxide. Mol Imaging 3:85–95
Pan JW, Hetherington HP, Vaughan JT, Mitchell G, Pohost GM, Whitaker JN (1996) Evaluation of multiple sclerosis by 1H spectroscopic imaging at 4.1 T. Magn Reson Med 36:72–77
Pirko I, Johnson A, Ciric B, Gamez J, Macura SI, Pease LR, Rodriguez M (2004) In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies. FASEB J 18:179–182
Pomper MG (2002) Can small animal imaging accelerate drug development? J Cell Biochem [Suppl] 39:211–220
Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P (1999) SENSE: sensitivity encoding for fast MRI. Magn Reson Med 42:952–962
Rausch M, Hiestand P, Baumann D, Cannet C, Rudin M (2003) MRI-based monitoring of inflammation and tissue damage in acute and chronic relapsing EAE. Magn Reson Med 50:309–314
Ray P, De A, Min JJ, Tsien RY, Gambhir SS (2004) Imaging trifusion multimodality reporter gene expression in living subjects. Cancer Res 64:1323–1330
Reichenbach JR, Essig M, Haacke EM, Lee BC, Przetak C, Kaiser WA, Schad LR (1998) High-resolution venography of the brain using magnetic resonance imaging. Magn Reson Mater Phys Biol Med (MAGMA) 6:62–69
Reichenbach JR, Jonetz-Mentzel L, Fitzek C, Haacke EM, Kido DK, Lee BC, Kaiser WA (2001) High resolution blood oxygen-level dependent MR venography (HRBV): a new technique. Neuroradiology 43:364–369
Schellenberger EA, Bogdanov A Jr, Hogemann D, Tait J, Weissleder R, Josephson L (2002) Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Mol Imaging 1:102–107
Schenck JF (2000) Safety of strong, static magnetic fields. Magn Reson Imaging 12:2–19
Shahbazi-Gahrouei D, Williams M, Rizvi S, Allen BJ (2001) In vivo studies of Gd-DTPA-monoclonal antibody and Gd-porphyrins: potential magnetic resonance imaging contrast agents for melanoma. J Magn Reson Imaging 14:169–174
Sodickson DK, Manning WJ (1997) Simultaneous acquisition of spatial harmonics (SMASH): fast imaging with radio-frequency coil arrays. Magn Reson Med 38:591–603
Stoll G, Wesemeier C, Gold R, Solymosi L, Toyka KV, Bendszus M (2004) In vivo monitoring of macrophage infiltration in experimental autoimmune neuritis by magnetic resonance imaging. J Neuroimmunol 149:142–146
’t Hart BA, Vogels J, Bauer J, Brok HP, Blezer E (2004) Non-invasive measurement of brain damage in a primate model of multiple sclerosis. Trends Mol Med 10:85–91
Thulborn KR, Waterton JC, Matthews PM, Radda GK (1982) Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta 714:265–270
Trapp BD, Bo L, Mork S, Chang A (1999) Pathogenesis of tissue injury in MS lesions. J Neuroimmunol 98:49–56
Tropres I, Lamalle L, Peoc’h M, Farion R, Usson Y, Decorps M, Remy C (2004) In vivo assessment of tumoral angiogenesis. Magn Reson Med 51:533–541
Ugurbil K, Garwood M, Ellermann J, Hendrich K, Hinke R, Hu X, Kim SG, Menon R, Merkle H, Ogawa S et al (1993) Imaging at high magnetic fields: initial experiences at 4 T. Magn Reson Q 9:259–277
Ugurbil K, Hu X, Chen W, Zhu X-H, Kim S-G, Georgopoulos A (1999) Functional mapping in the human brain using high magnetic fields. Philos Trans R Soc Lond B Biol Sci 354:1195–1213
Ugurbil K, Adriany G, Andersen P, Chen W, Garwood M, Gruetter R, Henry P, Kim SG, Lieu H, Tkac I, Vaughan T, van de Moortele PF, Yacoub E, Zhu XH (2003) Ultrahigh field magnetic resonance imaging and spectroscopy. Magn Reson Imaging 21:1263–1281
Vymazal J, Brooks RA, Baumgarner C, Tran V, Katz D, Bulte JW, Bauminger R, di Chiro G (1996) The relation between brain iron and NMR relaxation times: an in vitro study. Magn Reson Med 35:56–61
Weissleder R (2002) Scaling down imaging: molecular mapping of cancer in mice. Nat Rev Cancer 2:11–18
Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L (1990) Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 175:489–493
Wood JC, Fassler JD, Meade T (2004) Mimicking liver iron overload using liposomal ferritin preparations. Magn Reson Med 51:607–611
Xu S, Jordan EK, Brocke S, Bulte JW, Quigley L, Tresser N, Ostuni JL, Yang Y, McFarland HF, Frank JA (1998) Study of relapsing-remitting experimental allergic encephalomyelitis SJL mouse model using MION-46L enhanced in vivo MRI: early histopathological correlation. J Neurosci Res 52:549–558
Yang QX, Smith MB, Briggs RW, Rycyna RE (1999) Microimaging at 14 tesla using GESEPI for removal of magnetic susceptibility artifacts in T2*-weighted image contrast. J Magn Reson 141:1–6
Zelivyanskaya ML, Nelson JA, Poluektova L, Uberti M, Mellon M, Gendelman HE, Boska MD (2003) Tracking superparamagnetic iron oxide labeled monocytes in brain by high-field magnetic resonance imaging. J Neurosci Res 73:284–295
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Kangarlu, A. (2005). Molecular Imaging and High-Field MRI in Multiple Sclerosis. In: Filippi, M., De Stefano, N., Dousset, V., McGowan, J.C. (eds) MR Imaging in White Matter Diseases of the Brain and Spinal Cord. Medical Radiology Diagnostic Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27644-0_10
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