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Photoaging and Pigmentary Changes of the Skin

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Cosmetic Dermatology

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References

  1. Yaar M, Gilchrest BA (2001) Ageing and photoageing of keratinocytes and melanocytes. Clin Exp Dermatol 26: 583–591

    Article  PubMed  CAS  Google Scholar 

  2. Ortonne JP (1990) Pigmentary changes of the ageing skin. Br J Dermatol 122(Suppl): 21–28

    PubMed  Google Scholar 

  3. Kaidbey KH, Agin PP, Sayre RM, Kligman AM (1979) Photoprotection by melanin: a comparison of black and Caucasian skin J Am Acad Dermatol 1: 249–260

    PubMed  CAS  Google Scholar 

  4. Jazwinski SM (2000) Aging and longevity genes. Acta Biochim Pol 47(2): 269–279

    PubMed  CAS  Google Scholar 

  5. Barzilai N (2001) Searching for human longevity genes: the future history of gerontology in the postgenomic era. J Gerontol A Biol Sci Med Sci 56(2): M83–M87

    PubMed  CAS  Google Scholar 

  6. Yu CE, Oshima J, Wijsman EM, Hisama F, Alisch R (1996) Positional cloning of the Werner’s syndrome gene. Science 272: 258–262

    PubMed  CAS  Google Scholar 

  7. Ly DH, Lockhart DJ, Lerner RA, Schultz PG (2000) Mitotic misregulation and human aging. Science 287: 2486–2491

    Article  PubMed  CAS  Google Scholar 

  8. Blackburn EH (1991) Structure and function of telomeres. Nature 350: 569–573

    Article  PubMed  CAS  Google Scholar 

  9. Harley B, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345: 458–460

    Article  PubMed  CAS  Google Scholar 

  10. Schulz VP, Zakian VA, Ogburn CE, McKay J, Jarzebowicz AA, Edland SD, Martin GM (1996) Accelerated loss of telomeric repeats may not explain accelerated replicative decline or Werner’s syndrome cells. Hum Genet 97: 750–754

    Article  PubMed  CAS  Google Scholar 

  11. Greider CW, Blackburn EH (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43(Suppl 2): 405–413

    PubMed  CAS  Google Scholar 

  12. Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, de Lange T (1999) Mammalian telomeres end in a large duplex loop. Cell 97: 503–514

    Article  PubMed  CAS  Google Scholar 

  13. deLange T (2002) Protection of mammalian telomeres. Oncogene 21: 532–540

    CAS  Google Scholar 

  14. Karlseder J, Brocolli D, Dai Y, Hardy S, deLange T (1999) p53 and ATM dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321–1325

    Article  PubMed  CAS  Google Scholar 

  15. Pescott JC, Blackburn EH (1999) Telomerase: Dr. Jekyll or Mr. Hyde. Curr Opin Genet Dev 9: 368–373

    Google Scholar 

  16. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lechtsteiner S, Wright WE (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349–352

    Article  PubMed  CAS  Google Scholar 

  17. Eller MS, Puri N, Hadshiew IM, Venna SS, Gilchrest BA (2002) Induction of apoptosis by telomere 3′ overhang-specific DNA. Exp Cell Res 276: 185–193

    Article  PubMed  CAS  Google Scholar 

  18. Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 298–300

    PubMed  CAS  Google Scholar 

  19. Fridovich I (1989) Superoxide dismutases. An adaptation to a paramagnetic gas. J Biol Chem 264: 7761–7764

    PubMed  CAS  Google Scholar 

  20. Gilchrest BA (2003) Skin Aging 2003: Recent advances and current concepts. Cutis 72(Suppl 3): 5–10

    PubMed  Google Scholar 

  21. Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ (1997) Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med 337: 1419–1428

    Article  PubMed  CAS  Google Scholar 

  22. Kang S, Chung JH, Lee JH, Fisher GJ, Wan YS, Duell EA, Voorhees JJ (2003) Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo. J Invest Dermatol 120: 835–841

    Article  PubMed  CAS  Google Scholar 

  23. Yaar M, Gilchrest BA (1999) Aging of skin. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, Fitzpatrick TB (eds) Dermatology in general medicine. McGraw-Hill, New York, pp 1697–1706

    Google Scholar 

  24. deRigal J, Escoffier C, Querleux B, Faivre B, Agache P, Leveque JL (1989) Assessment of aging of the human skin by invo ultrasonic imaging. J Invest Dermatol 93: 621–625

    CAS  Google Scholar 

  25. Gilchrest BA, Blog FB, Szabo G (1979) Effects of aging and chronic sun exposure on melanocytes in human skin. J Invest Dermatol 73: 141–143

    Article  PubMed  CAS  Google Scholar 

  26. Goh SH (1990) The treatment of visible signs of senescence: the Asian experience. Br J Dermatol 122: 105–109

    PubMed  Google Scholar 

  27. Chung JH, Lee SH, Youn CS, Park Bj, Kim KH, Park KC, Cho KH, Eun HC (2001) Cutaneous photodamage in Koreans. Arch Dermtol 137: 1043–1051

    CAS  Google Scholar 

  28. Kwon OS, Hwang EJ, Bae JH, Park HE, Lee JC, Youn JI, Chung JH (2003) Seborrheic keratosis in the Korean males: causative role of sunlight. Photodermatol Photoimmunol Photomed 19: 73–80

    PubMed  Google Scholar 

  29. Kaidbey KH, Agin PP, Sayre RM, Kligman AM (1979) Photoprotection by melanin: a comparison of black and Caucasian skin. J Am Acad Dermatol 1: 249–260

    Article  PubMed  CAS  Google Scholar 

  30. Halder RM, Grimes PE, McLaurin CI, Kress MA, Kenney JA (1983) Incidence of common dermatoses in a predominantly black dermatology practice. Cutis 133: 1296–1299

    Google Scholar 

  31. Halder RM (1998) The role of retinoids in the management of cutaneous conditions in blacks. J Am Acad Dermatol 39: S98–S103

    Article  PubMed  CAS  Google Scholar 

  32. Montagna W, Carlisle K (1991) The architecture of black and white facial skin. J Am Acad Dermatol 24: 929–937

    PubMed  CAS  Google Scholar 

  33. Taylor SC, DeYampert NM (2004) Treatment of Photoaging in African American and Hispanic Patients. In: Rigel DS, Weiss RA, Lim HW, Dover JS (eds) Photoaging. Marcel Dekker, New York, pp 365–377

    Google Scholar 

  34. Moyal D, Fourtanier A (2004) Acute and chronic effects of UV on skin. In: Rigel DS, Weiss RA, Lim HW, Dover JS (eds) Photoaging. Marcel Dekker, New York, pp 15–32

    Google Scholar 

  35. Cummings K, Cottel W (1966) Idiopathic guttate hypomelanosis. Arch Dermatol 93: 184–186

    Article  PubMed  CAS  Google Scholar 

  36. Warren R, Gartstein V, Kligman AM, Montagna W, Allendorf RA, Ridder GM (1991) Age, sunlight, and facial skin: A histologic and quantitative study. J Am Acad Dermatol 25: 751–760

    PubMed  CAS  Google Scholar 

  37. Ortonne JP (1990) Pigmentary changes of the ageing skin. Br J Dermatol 122: 21–28

    PubMed  Google Scholar 

  38. Castanet J, Ortonne J-P (1997) Pigmentary changes in aged and photoaged skin. Arch Dermatol 133: 1296–299

    Article  PubMed  CAS  Google Scholar 

  39. Breathmach AS, Nazzaro-Porro M, Passi S, Picardo M (1991) Ultrastructure of melanocytes in chronically sun-exposed skin of elderly subjects. Pigment Cell Res 4: 71–79

    Google Scholar 

  40. Garbe C, Buttner P, Weiss J, Soyerf HP, Stocker U, Kruger S, Roser M, Weckbecker J, Panizzon R, Bahmer F (1994) Associated factors in the prevalence of more than 50 common melanocytic nevi, atypical melanocytic nevi and actinic lentigines: multicenter case-control study of the Central Malignant Melanoma Registry of the German Dermatological Society. J Invest Dermatol 102: 700–705

    PubMed  CAS  Google Scholar 

  41. Holzle E (1992) Pigmented lesions as a sign of photodamage. Br J Dermatol 127(Suppl 41): 48–50

    PubMed  Google Scholar 

  42. Adhoute H, Grossman R, Cordier M, Soler B (1994) Chromametric quantification pigmentary changes in the solar lentigo after sunlight exposure. Photodermatol Photoimmunol Photomed 10: 93–96

    PubMed  CAS  Google Scholar 

  43. Bolognia JL (1992) Reticulated black solar lentigo (’ink spot’ lentigo). Arch Dermatol 128: 934–940

    PubMed  CAS  Google Scholar 

  44. Cummings K, Cottel W (1966) Idiopathic guttate hypomelanosis. Arch Dermatol 93: 184–186

    Article  PubMed  CAS  Google Scholar 

  45. Montagna W, Kirchner S, Carlisle K (1989) Histology of sun-damaged human skin. J Am Acad Dermatol 21: 907–18

    PubMed  CAS  Google Scholar 

  46. Warren R, Gartstein V, Kligman AM, Montagna W, Allendorf RA, Ridder GM (1991) Age, sunlight, and facial skin: A histologic and quantitative study. J Am Acad Dermatol 25: 751–760

    PubMed  CAS  Google Scholar 

  47. Kotrajaras R, Kligman AM (1993) The effect of topical tretinoin on photodamaged facial skin: the Thai experience. Br J of Dermatol 129: 302–309

    CAS  Google Scholar 

  48. Toyoda M, Bhawan J (1995) Electron-microscopic observations of cutaneous photoaging versus intrinsic aging. J Geriatr Dermatol 3(5): 131–143

    Google Scholar 

  49. Shuster S, Black MM, McVitie E (1975) The influence of age and sex on skin thickness, skin collagen and density. Br J Dermatol 93: 639–643

    PubMed  CAS  Google Scholar 

  50. Burke EM, Horton WE, Pearson JD, Crow MT, Martin GR (1994) Altered transcriptional regulation of human interstitial collagenase in cultured skin fibroblasts from older donors. Exp Gerontol 29: 37–53

    Article  PubMed  CAS  Google Scholar 

  51. Montagna W, Carlisle K (1991) The architecture of black and white facial skin. J Am Acad Dermatol 24: 929–937

    PubMed  CAS  Google Scholar 

  52. Quevedo WC, Szabo G, Verks J (1969) Influence of age and UV on the population of dopa-positive melanocytes in human skin. J Invest Dermatol 52: 287–290

    PubMed  CAS  Google Scholar 

  53. Snell RS, Bischitz PG (1963) The melanocytes and melanin in human abdominal wall skin: a survey made at different ages in both sexes and during pregnancy. J Anat 97: 361–376

    PubMed  CAS  Google Scholar 

  54. Friedmann PS, Gilchrest BA (1987) Ultraviolet radiation directly induces pigment production by cultured human melanocytes. J Cell Physiol 133: 88–94

    Article  PubMed  CAS  Google Scholar 

  55. Barker D, Dixon K, Medrano EE, Smalara D, Im S, Mitchell D, Babcock G, Abdel-Malek ZA (1995) Comparison of the responses of human melanocytes with melanin contents to ultraviolet B irradiation. Cancer Res 55: 4041–4046

    PubMed  CAS  Google Scholar 

  56. Mckenzie RC, Park ES, Brown WR, Shivji GS, Sauder DN (1994) Effect of ultraviolet-inducible cytokines on melanoma growth in vivo: stimulation of melanoma growth by interleukin-1 and-6. Photodermatol Photoimmunol Photomed 10: 74–79

    PubMed  CAS  Google Scholar 

  57. Halaban R, Langdon R, Birchall N, Cuono C, Baird A, Scott G, Moellmann G, McGuire J (1988) Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes. J Cell Biol 107: 1611–1619

    Article  PubMed  CAS  Google Scholar 

  58. Yada Y, Higuchi K, Imokawa G (1991) Effects of endothelins on signal transduction and proliferation in human melanocytes. J Biol Chem 226: 18352–18357

    Google Scholar 

  59. Imokawa G, Yada Y, Miyagishi M (1992) Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes J Biol Chem 267: 24675–24680

    PubMed  CAS  Google Scholar 

  60. Medrano EE, Farooqui JZ, Boissy RE, Boissy YL, Akadiri B, Nordlund JJ (1993) Chronic growth stimulation of human adult melanocytes by inflammatory mediators in vitro: implications for nevus formation and initial steps in melanocyte oncogenesis. Proc Natl Acad Sci USA 90: 1790–1794

    PubMed  CAS  Google Scholar 

  61. Hodgson F (1963) Senile lentigo. Arch Dermatol 87: 197–207

    PubMed  CAS  Google Scholar 

  62. Braun-Falco O, Schoefinius HH (1971) Lentigo seniles. Hautarst 22: 277–283

    CAS  Google Scholar 

  63. Kang S, Chung JH, Lee JH, Fisher GJ, Wan YS, Duell EA, Voorhees JJ (2003) Topical N-Acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo. J Invest Dermatol 120: 835–841

    Article  PubMed  CAS  Google Scholar 

  64. Jurkicwicz BA, Bissett DL, Buettner GR (1995) Effect of topically applied tocopherol on ultraviolet radiation-mediated free radical damage in skin. J Invest Dermatol 104: 484–488

    Google Scholar 

  65. Darr D, Combs S, Dunston S, Manning T, Pinnell S (1992) Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage. Br J Dermatol 127: 247

    PubMed  CAS  Google Scholar 

  66. Traikovich SS (1999) Use of topical ascorbic acid and its effect on photodamaged skin topography Arch Otolaryngol Head Neck Surg 125: 1091–1098

    PubMed  CAS  Google Scholar 

  67. Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, Voorhees JJ (1988) Topical tretinoin improves photoaged skin: A double-blind vehicle-controlled study. JAMA 259: 527–532

    Article  PubMed  CAS  Google Scholar 

  68. Ellis CN, Weiss JS, Hamilton TA, Headington JT, Zelickson AS, Voorhees JJ (1990) Sustained improvement with prolonged topical tretinoin (retinoic acid) for photoaged skin. J Am Acad Dermatol 23: 629–637

    Article  PubMed  CAS  Google Scholar 

  69. Rafal ES, Griffiths CE, Ditre CM. Finkel LJ, Hamilton TA, Ellis CN, Voorhees JJ (1992) Topical tretinoin treatment for liver spots associated with photodamage. NEJM 326: 368–374

    PubMed  CAS  Google Scholar 

  70. Griffiths CE, Goldfarb MT, Finkel LJ, Roulia V, Bonawitz M, Hamilton TA, Ellis CN, Voorhees JJ (1994) Topical tretinoin (retinoic acid) treatment of hyperpigmented lesions associated with photoaging in Chinese and Japanese patients: A vehicle-controlled trial. J Am Acad Dermatol 30: 76–84

    Article  PubMed  CAS  Google Scholar 

  71. Bulengo-Ransby SM, Griffiths CE, Kimbrough-Green CK, Finkel LJ, Hamilton TA, Ellis CN, Voorhees JJ (1993) Topical Tretinoin (retinoic acid) therapy for hyperpigmented lesions caused by inflammation of the skin in black patients. New Engl J Med 328: 1438–1443

    Article  PubMed  CAS  Google Scholar 

  72. Kang S, Goldfarb MT, Weiss JS, Metz RD, Hamilton TA, Voorhees JJ, Griffiths CEM (2003) Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial. J Am Acad Dermatol 49: 83–90

    Article  PubMed  Google Scholar 

  73. Phillips TJ, Gottleib AB, Leyden JJ, Lowe NJ, Lew-Kaya DA, Sefton J, Walker PS, Gibson JR (2002) Efficacy of 0.1% tazarotene cream for the treatment of photodamage. Arch Dermatol 138: 1486–1493

    PubMed  CAS  Google Scholar 

  74. Sanchez JL, Vasquez M (1982) A hydroquinone solution in the treatment of melasma. Int J Dermatol 21: 55–58

    PubMed  CAS  Google Scholar 

  75. Ruiz-Maldonado R, Orozco-Covarrubias M, de la Luz (1997) Post inflammatory Hypopigmentation and hyperpigmentation. Semin Cutan Med Surg 16: 36–43

    PubMed  CAS  Google Scholar 

  76. Glenn M, Grimes PE, Pitt E, Chalet M, Kelley AP (1991) Evaluation of clinical and light microscopic effects of various concentrations of hydroquinone Clin Res 39: 83A

    Google Scholar 

  77. Yoshimura K, Aoyama T, Iga T (2000) Experience with a strong bleaching treatment for skin hyperpigmentation in Orientals. Plast Reconstr Surg 105: 1097

    PubMed  CAS  Google Scholar 

  78. Fleischer AB, Schwartzel EH, Colby SI, Altman DJ, and the Depigmenting solution study group (2000) The combination of 2% 4-hydroxyanisole (Mequinol) and 0.01% tretinoin is effective in improving the appearance of solar lentigines and related hyperpigmented lesions in two double-blind Multicenter clinical studies. J Am Acad Dermatol 42: 459–467

    Article  PubMed  Google Scholar 

  79. Almond-Roesler B, Zouboulis CH (2000) Successful treatment of solar lentigines by brief gentle cryosurgery using a Kryomed device. Br J Dermatol 143: 216–218

    Article  PubMed  CAS  Google Scholar 

  80. Zouboulis ChC, Rosenberger AD, Adler Y, Orfanos CE (1999) Treatment of solar lentigo with cryosurgery. Acta Derm Venereol 79: 489–490

    PubMed  CAS  Google Scholar 

  81. Hexel DM, Mazzuco R, Bohn J, Borges J, Gobbato DO (2000) Clinical comparative study between cryotherapy and local dermabrasion for the treatment of solar lentigo on the back of hands. Dermatol Surg 26: 247–462

    Google Scholar 

  82. Kopera D, Hohenleutner U, Landthaler M (1997) Quality-switched ruby laser treatment of solar lentigines and Becker’s nevus: a histopathological and immunohistochemical study. Dermatology 194: 338–343

    PubMed  CAS  Google Scholar 

  83. Rosenbach A (2002) Treatment of medium-brown solar lentigines using an alexandrite laser designed for hair reduction. Arch Dermatol 138: 547–548

    Article  PubMed  Google Scholar 

  84. Chan HH (2004) Treatment of Photoaging in Asian Skin. In: Rigel DS, Weiss RA, Lim HW, Dover JS (eds) Photoaging. Marcel Dekker, New York, pp 343–364

    Google Scholar 

  85. Negishi K, Tezuka Y, Kushidata N, Wakamatsu S (2001) Photorejuvenation for Asian skin by intense pulsed light. Dermatol Surg 27: 627–632

    Article  PubMed  CAS  Google Scholar 

  86. Kawada A, Shiraish H, Asai M, Kameyama H, Sangen Y, Aragene Y, Tezuka T (2002) Clinical improvement of solar lentigines and ephelides with an intense pulsed light source. Dermatol Surg 28: 504–505

    Article  PubMed  Google Scholar 

  87. Cotellessa C, Peris K, Fargnoli MC, Mordenti C, Giacomello RS, Chimeti S (2003) Microabrasion versus microabrasion followed by 15% trichloroacetic acid for treatment of cutaneous hyperpigmentation in adult females. Dermatol Surg 29: 352–356

    Article  PubMed  Google Scholar 

  88. Lugo-Janer A, Lugo-Somolinos A, Sanchez JL (2003) Comparison of trichloroacetic acid solution and cryosurgery in the treatment of solar lentigines. Int J Dermatol 42: 829–831

    Article  PubMed  Google Scholar 

  89. Li Y-T, Yang K-C (1999) Comparison of the frequency-doubled Q-switched Nd: YAG laser and 35% trichloroacetic acid for the treatment of face lentigines. Dermatol Surg 25(3): 202–204

    Article  PubMed  CAS  Google Scholar 

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Taylor, S.C. (2005). Photoaging and Pigmentary Changes of the Skin. In: Burgess, C.M. (eds) Cosmetic Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27333-6_3

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