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References
Albrecht T, Blomley M, Bolondi L et al (2004) Guidelines for the use of contrast agents in ultrasound. Ultraschall Med 25:249–256
Andre M, Nelson T, Mattrey RF (1990) Physical and acoustical properties of perfluorooctyl bromide, an ultrasound contrast agent. Invest Radiol 25:983–987
Basilico R, Blomley MJ, Cosgrove DO (2002) The first phase I study of a novel ultrasound contrast agent (BR14): assessment of safety and efficacy in liver and kidneys. Acad Radiol 9[Suppl 2]:S380–S381
Bauer A, Blomley MJK, Leen E, Cosgrove D, Schlief R (1999) Liver-specific imaging with SHU 563 A: diagnostic potential of a new class of ultrasound contrast media. Eur Radiol 9[Suppl 3]:S349–S352
Blomley MJK, Albrecht T, Cosgrove DO et al (1998) Stimulated acoustic emission in liver parenchyma with Levovist. Lancet 351:568–569
Bove A, Ziskin M (1969) Ultrasonic detection of in vivo cavitation and pressure effects of high speed injection through catheters. Invest Radiol 3:236–241
Campbell S, Bourne TH, Tan SL, Collins WP (1994) Hysterosalpingo contrast sonography (HyCoSy) and its future role within the investigation of infertility in Europe. Ultrasound Obstet Gynecol 4:245–253
Chatterjee D, Sarkar K (2003) A Newtonian rheological model for the interface of microbubble contrast agents. Ultrasound Med Biol 29:1749–1757
Claudon M, Jager KA (2004) It is time to establish guidelines for the use of ultrasound contrast agents. Ultraschall Med 25:247–248
Claudon M, Plouin PF, Baxter G et al (2000) Renal arteries in patients at risk of renal arterial stenosis: multicenter evaluation of the echo-enhancer SH U 508A at color and spectral Doppler US. Levovist Renal Artery Stenosis Study Group. Radiology 214:739–746
Claudon M, Tranquart F, Evans AH et al (2002) Advances in Ultrasound. Eur Radiol 12(1):7–18
Correas JM, Kessler D, Worah D, Quay SC (1997) The first phase shift ultrasound contrast agent: EchoGen. In: Goldberg BB (ed) Ultrasound contrast agents. Dunitz, London, pp 101–120
Correas JM, Burns PN, Lai X, Qi X (2000) Infusion versus Bolus of an ultrasound contrast agent: in vivo dose-response measurements of BR1. Invest Radiol 35:72–79
Correas JM, Bridal L, Lesavre A et al (2001) Ultrasound contrast agents: properties, principles of action, tolerance, and artifacts. Eur Radiol 11:1316–1328
de Jong N, Hoff L, Skotland T, Bom N (1992) Absorption and scatter of encapsulated gas filled microspheres: theoretical considerations and some measurements. Ultrasonics 30:95–103
Droste DW, Lakemeier H, Ritter M et al (2004a) The identification of right-to-left shunts using contrast transcranial Doppler ultrasound: performance and interpretation modalities, and absence of a significant side difference of cardiac micro-emboli. Neurol Res 26:325–330
Droste DW, Schmidt-Rimpler C et al (2004b) Right-to-left-shunts detected by transesophageal echocardiography and transcranial Doppler sonography. Cerebrovasc Dis 17:191–196
Fisher NG, Christiansen JP, Leong-Poi H et al (2002) Myocardial and microcirculatory kinetics of BR14, a novel thirdgeneration intravenous ultrasound contrast agent. J Am Coll Cardiol 39:530–537
Forsberg F, Tao Shi W (2001) Physics of contrast microbubbles. In: Goldberg B, Raichlen JS, Forsberg F (eds) Ultrasound contrast agents: basic principles and clinical applications. Dunitz, London, pp 15–23
Forsberg F, Goldberg BB, Liu JB et al (1999) Tissue specific US contrast agent for evaluation of hepatic and splenic parenchyma. Radiology 210:125–132
Forsberg F, Liu JB, Merton DA et al (2000) Gray scale second harmonic imaging of acoustic emission signals improves detection of liver tumors in rabbits. J Ultrasound Med 19:557–563
Forsberg F, Piccoli CW, Liu JB et al (2002) Hepatic tumor detection: MR imaging and conventional US versus pulse-inversion harmonic US of NC100100 during its reticuloendothelial system-specific phase. Radiology 222:824–829
Frinking PJA (1999) Ultrasound contrast agents: acoustic characterization and diagnostic imaging. Optima Grafische Communicatie, Rotterdam, The Netherlands
Goldberg BB, Liu JB, Forsberg (1994) Ultrasound contrast agents: a review. Ultrasound Med Biol 20:319–333
Gorce JM, Arditi M, Schneider M (2000) Influence of bubble size distribution on the echogenicity of ultrasound contrast agents: a study of SonoVue. Invest Radiol 35:661–671
Gramiak R, Shah PM (1968) Echocardiography of the aortic root. Invest Radiol 3:356–366
Harvey CJ, Blomley MJK, Eckersley RJ, Cosgrove DO (2001) Developments in ultrasound contrast media. Eur Radiol 11:675–689
Hauff P, Fritsch T, Reinhardt M et al (1997) Delineation of experimental liver tumors in rabbits by a new ultrasound contrast agent and stimulated acoustic emission. Invest Radiol 32:94–99
Killam A, Dittrich HC (1997) Cardiac applications of Albunex and FS069. In: Goldberg BB (ed) Ultrasound contrast agents. Dunitz, London, pp 43–55
Kindberg GM, Tolleshaug H, Roos N, Skotland T (2003) Hepatic clearance of Sonazoid perfluorobutane microbubbles by Kupffer cells does not reduce the ability of liver to phagocytose or degrade albumin microspheres. Cell Tissue Res 312:49–54
Kitamura H, Kawasaki S, Nakajima K et al (2002) Correlation between microbubble contrast-enhanced color Doppler sonography and immunostaining for Kupffer cells in assessing the histopathologic grade of hepatocellular carcinoma: preliminary results. J Clin Ultrasound 30:465–471
Kitzman DW, Wesley DJ (2000) Safety assessment of perflenapent emulsion for echocardiographic contrast enhancement in patients with congestive heart failure or chronic obstructive pulmonary disease. Am Heart J 139:1077–1080
Kabalnov A, Klein D, Pelura T et al (1998a) Dissolution of multicomponent microbubble in the blood stream: 1. Theory. Ultrasound Med Biol 24:739–749
Kabalnov A, Bradley JA, Flam S et al (1998b) Dissolution of multicomponent microbubble in the blood stream: 2. Experiment. Ultrasound Med Biol 24:751–760
Kono Y, Steinbach GC, Peterson T et al (2002) Mechanism of parenchymal enhancement of the liver with a microbubble-based US contrast medium: an intravital microscopy study in rats. Radiology 224:253–257
Kremkau FW, Gramiak R, Cartensen EL, Shah PM, Kramer H (1970) Ultrasonic detection of cavitation at catheter tips. AJR Am J Roentgenol 110:177–183
Kudo M, Tomita S, Tochio H et al (1992a) Sonography with intraarterial infusion of carbon dioxide microbubbles (sonographic angiography): value in differential diagnosis of hepatic tumors. Am J Roentgenol 158:65–74
Kudo M, Tomita S, Tochio H et al (1992b) Small hepatocellular carcinoma: diagnosis with US angiography with intraarterial CO2 microbubbles. Radiology 182:155–160
Lanza GM, Wallace KD, Scott MJ et al (1996) A novel site-targeted ultrasonic contrast agent with broad biomedical application. Circulation 94:3334–3340 (erratum in Circulation 1997, 95:2458)
Lindner JR, Dayton PA, Coggins MP et al (2000) Noninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles. Circulation 102:531–538
Lund PJ, Fritz TA, Unger EC et al (1992) Cellulose as a gastrointestinal US contrast agent. Radiology 185:783–788
Marelli C (1999) Preliminary experience with NC100100, a new ultrasound contrast agent for intravenous injection. Eur Radiol 9[Suppl 3]:S343–S346
Maruyama H, Matsutani S, Saisho H et al (2000) Grey-scale contrast enhancement in rabbit liver with DMP115 at different acoustic power levels. Ultrasound Med Biol 26:1429–1438
Maruyama H, Matsutani S, Saisho H et al (2003) Extra-low acoustic power harmonic images of the liver with perflutren. Novel imaging for real-time observation of liver perfusion. J Ultrasound Med 22:931–938
Maruyama H, Matsutani S, Saisho H et al (2004) Different behaviors of microbubble in the liver: time-related quantitative analysis of two ultrasound contrast agents, Levovist and Definity. Ultrasound Med Biol 30:1035–1040
Matsuda Y, Yabuuchi I, Ito T (1998) Properties of gas (CO2) microbubbles made by hand agitation and it's contrast enhancing effect. Nippon Rinsho 56:866–870
Mattrey RF, Aguirre D (2003) Advances in contrast media research. Acad Radiol 10:1450–1460
Mattrey RF, Pelura TJ (1997) Perfluorocarbon-based ultrasound contrast agents. In: Goldberg BB (ed) Ultrasound contrast agents. Dunitz, London, pp 83–99
Mattrey RF, Scheible FW, Gosink BB et al (1982) Perfluorooctyl bromide: a liver/spleen-specific and tumour-imaging ultrasound contrast material. Radiology 145:759–762
Mattrey RF, Wrigley R, Steinbach GC et al (1994) Gas emulsions as ultrasound contrast agents. Preliminary results in rabbits and dogs. Invest Radiol 29[Suppl 2]:S139–S141
Meuwl JY, Correas JM, Bleuzen A, Tranquart F (2003) Detection modes of ultrasound contrast agents. J Radiol 84:2013–2024
Morel DR, Schwieger I, Hohn L et al (2000) Human pharmacokinetics and safety evaluation of SonoVue™, a new contrast agent for ultrasound imaging. Invest Radiol 35:80–85
Perkins AC, Frier M, Hindle AJ et al (1997) Human biodistribution of an ultrasound contrast agent (Quantison) by radiolabelling and gamma scintigraphy. Br J Radiol 70:603–611
Quaia E, Blomley MJK, Patel S et al (2002) Initial observations on the effect of irradiation on the liver-specific uptake of Levovist. Eur J Radiol 41:192–199
Rott HD (1999) Safety of ultrasonic contrast agents. European Committee for Medical Ultrasound Safety. Eur J Ultrasound 9:195–197
Schneider M, Arditi M, Barrau MB et al (1995) BR1 a new ultrasonographic contrast agent based on sulphur hexafluoride-filled microbubbles. Invest Radiol 30:451–457
Schneider M, Broillet A, Bussat P et al (1997) Gray-scale liver enhancement in VX2 tumor bearing rabbits using BR14, a new ultrasonographic contrast agent. Invest Radiol 32:410–417
Schutt EG, Klein DH, Mattrey RM, Riess JG (2003) Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals. Angew Chem Int Ed Engl 42:3218–3235
Shen CC, Li PC (2003) Pulse-inversion-based fundamental imaging for contrast detection. IEEE Trans Ultrason Ferroelectr Freq Control 50:1124–1133
Unger E, Fritz T, McCreery T et al (1997) Lyposomes as myocardial perfusion ultrasound contrast agents. In: Goldberg BB (ed) Ultrasound contrast agents. Dunitz, London, pp 57–74
Walday P, Tolleshaug H, Gjoen T et al (1994) Biodistributions of air-filled albumin microspheres in rats and pigs. Biochem J 199:437–443
Wheatley MA (2001) Composition of contrast microbubbles: basic chemistry of encapsulated and surfactant-coated bubbles. In: Goldberg B, Raichlen JS, Forsberg F (eds) Ultrasound contrast agents: basic principles and clinical applications. Dunitz, London, pp 3–11
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Quaia, E. (2005). Classification and Safety of Microbubble-Based Contrast Agents. In: Quaia, E. (eds) Contrast Media in Ultrasonography. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27214-3_1
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