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Hormones and the Brain pp 213–225Cite as

Estrogens, Aging, and Neurodegenerative Diseases

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Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI))

Summary

Age is the greatest risk factor in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Indications of a female bias in AD and of a male bias in PD have been often discussed but are not definitive. Moreover, evidence that estrogen replacement may be beneficial for AD and PD is also controversial. An unevaluated factor is how aging and cumulative estrogen exposure may modify brain responses to estradiol. Rodent models show that sustained exposure to estradiol can desensitize certain neuroendocrine responses.

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References

  • Benedetti M, Bower J, Maraganore D, McDonnell S, Rocca W (1998) Postmenopausal estrogen replacement therapy and Parkinson’s disease: a population based study in Olmstead County, Minnesota. Mov Disord 13(Suppl 2):51.

    Google Scholar 

  • Breitner JC, Zandi PP (2003) Effects of estrogen plus progestin on risk of dementia [comment]. JAMA 290:1706–1707; author reply, 1707–1708.

    Article  Google Scholar 

  • Brinton RD, Nilsen J (2003) Effects of estrogen plus progestin on risk of dementia [comment]. JAMA 290:1706; author reply, 1707–1708.

    Article  Google Scholar 

  • de Rijk MC, Launer LJ, Berger K, Breteler MM, Dartigues JF, Baldereschi M, Fratiglioni L, Lobo A, Martinez-Lage J, Trenkwalder C, Hofman A (2000) Prevalence of Parkinson’s disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 54:S21–S23.

    Google Scholar 

  • Diamond SG, Markham CH, Hoehn MM, McDowell FH, Muenter MD (1990) An examination of male-female differences in progression and mortality of Parkinson’s disease. Neurology 40:763–766.

    PubMed  Google Scholar 

  • Dluzen DE (2000) Neuroprotective effects of estrogen upon the nigrostriatal dopaminergic system. J Neurocytol 29:387–399.

    Article  PubMed  Google Scholar 

  • Finch CE, Felicio LS, Mobbs CV, Nelson JF (1984) Ovarian and steroidal influences on neuroendocrine aging processes in female rodents. Endocrine Rev 5:467–497.

    Google Scholar 

  • Finch C, Morgan T, Rozovsky I, Xie Z, Weindruch R, Prolla T (2002). Microglia and aging in the brain. In: Streit W (ed) Microglia in the regenerating and degenerating central nervous system. New York: Springer-Verlag pp 275–305.

    Google Scholar 

  • Gosden RG, Finch CE (2000) Definition and character of reproductive ageing. In: te Velde E, Pearson P, Broekmans F (eds) Female reproductive aging New York: Parthenon Publishing pp 11–26.

    Google Scholar 

  • Gosden RG, Laing SC, Felicio LS, Nelson JF, Finch CE (1983) Imminent oocyte exhaustion and reduced follicular recruitment mark the transition to acyclicity in aging C57BL/6J mice. Biol Reprod 28:255–260.

    PubMed  Google Scholar 

  • Horstink MW, Strijks E, Dluzen DE (2003) Estrogen and Parkinson’s disease. Adv Neurol 91:107–14.

    PubMed  Google Scholar 

  • Jellinger KA, Mitter-Ferstl E (2003) The impact of cerebrovascular lesions in Alzheimer disease-a comparative autopsy study. J Neurol 250:1050–1055.

    Article  PubMed  Google Scholar 

  • Jezierski MK, Sohrabji F (2001) Neurotrophin expression in the reproductively senescent forebrain is refractory to estrogen stimulation. Neurobiol Aging 22:309–219.

    Article  PubMed  Google Scholar 

  • Kawas CH, Katzman R (1999) Epidemiology of dementia and Alzheimer disease. In: Morris J, Terry R, Katzman R, Bick K, Sisodia S (eds) Alzheimer disease. Philadelphia: Lippincott Williams & Willkins pp 95–116.

    Google Scholar 

  • Kohama SG, Anderson CP, Osterburg HH, May PC, Finch CE (1989) Oral administration of estradiol to young C57BL/6J mice induces age-like neuroendocrine dysfunctions in the regulation of estrous cycles. Biol Reprod 41:227–232.

    PubMed  Google Scholar 

  • Kompoliti K, Comella CL, Jaglin JA, Leurgans S, Raman R, Goetz CG (2000) Menstrual-related changes in motoric function in women with Parkinson’s disease. Neurology 55:1572–1575.

    PubMed  Google Scholar 

  • Kukull WA, Higdon R, Bowen JD, McCormick WC, Teri L, Schellenberg GD, van Belle G, Jolley L, Larson EB (2002) Dementia and Alzheimer disease incidence: a prospective cohort study. Arch Neurol 59:1737–1746.

    Article  PubMed  Google Scholar 

  • Lamberts SW (2003) The endocrinology of gonadal involution: menopause and andropause. Ann Endocrinol 64:77–81.

    Google Scholar 

  • Lott IT, Head E (2001) Down syndrome and Alzheimer’s disease: a link between development and aging. Ment Retard Dev Disabil Res Rev 7:172–178.

    Article  PubMed  Google Scholar 

  • Marder K, Tang MX, Alfaro B, Mejia H, Cote L, Jacobs D, Stern Y, Sano M, Mayeux R (1998) Postmenopausal estrogen use and Parkinson’s disease with and without dementia. Neurology 50:1141–1143.

    PubMed  Google Scholar 

  • Mayeux R (2003) Epidemiology of neurodegeneration. Annu Rev Neurosci 26:81–104.

    Article  PubMed  Google Scholar 

  • Mayeux R, Marder K, Cote LJ, Denaro J, Hemenegildo N, Mejia H, Tang MX, Lantigua R, Wilder D, Gurland B (1995) The frequency of idiopathic Parkinson’s disease by age, ethnic group, and sex in northern Manhattan, 1988–1993[erratum appears in Am J Epidemiol 1996 143(5):528]. Am J Epidemiol 142:820–827.

    PubMed  Google Scholar 

  • Miller DB, Ali SF, O’Callaghan JP, Laws SC (1998) The impact of gender and estrogen on striatal dopaminergic neurotoxicity. Ann NY Acad Sci 844:153–165.

    PubMed  Google Scholar 

  • Morgan TE, Xie Z, Goldsmith S, Yoshida T, Lanzrein AS, Stone D, Rozovsky I, Perry G, Smith MA, Finch CE (1999) The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction. Neuroscience 89:687–699.

    Article  PubMed  Google Scholar 

  • Murakami K, Nakagawa T, Shozu M, Uchide K, Koike K, Inoue M (1999) Changes with aging of steroidal levels in the cerebrospinal fluid of women. Maturitas 33:71–80.

    Article  PubMed  Google Scholar 

  • Nelson JF, Felicio LS, Osterburg HH, Finch CE (1992) Differential contributions of ovarian and extraovarian factors to age-related reductions in plasma estradiol and progesterone during the estrous cycle of C57BL/6J mice. Endocrinology 130:805–810.

    Article  PubMed  Google Scholar 

  • Nichols NR, Day JR, Laping NJ, Johnson SA, Finch CE (1993) GFAP mRNA increases with age in rat and human brain. Neurobiol Aging 14:421–429.

    Article  PubMed  Google Scholar 

  • O’Neill K, Chen S, Brinton R (2004) Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer’s disease. Exp Neurol. 185:63–80.

    Article  PubMed  Google Scholar 

  • Paganini-Hill A, Henderson VW (1994) Estrogen deficiency and risk of Alzheimer’s disease in women. Am J Epidemiol 140:256–261.

    PubMed  Google Scholar 

  • Quinn NP, Marsden CD (1986) Menstrual-related fluctuations in Parkinson’s disease. Mov Disord 1:85–87.

    Article  PubMed  Google Scholar 

  • Ritchie K (1995) Mental status examination of an exceptional case of longevity J. C. aged 118 years. Brit J Psych 166:229–235.

    Google Scholar 

  • Rostene W, Callier S, D’astous M, Grandbois M, Lesaux M, Bedard P, Di Paolo T, Pelaprat D (2003) Sex steriods in normal and pathological aging: implication in dopaminergic neurodegeneration. Fondation IPSEN Symposium, abstract.

    Google Scholar 

  • Rozovsky I, Wei M, Stone DJ, Zanjani H, Anderson CP, Morgan TE, Finch CE (2002) Estradiol (E2) enhances neurite outgrowth by repressing glial fibrillary acidic protein expression and reorganizing laminin. Endocrinology 143:636–646.

    Article  PubMed  Google Scholar 

  • Rozovsky I, Wei M, Morgan TE, Finch CE (2004) Reversible age unpairments in neurite outgrowth by manipulations of astrocytic GFAP. Neurobiol Aging (in press).

    Google Scholar 

  • Santoro N, Brown JR, Adel T, Skurnick JH (1996) Characterization of reproductive hormonal dynamics in the perimenopause. J Clin Endocrinol Metabol 81:1495–1501.

    Article  Google Scholar 

  • Saunders-Pullman R, Gordon-Elliott J, Parides M, Fahn S, Saunders HR, Bressman S (1999) The effect of estrogen replacement on early Parkinson’s disease. Neurology 52:1417–1421.

    PubMed  Google Scholar 

  • Schonknecht P, Pantel J, Klinga K, Jensen M, Hartmann T, Salbach B, Schroder J (2001) Reduced cerebrospinal fluid estradiol levels are associated with increased beta-amyloid levels in female patients with Alzheimer’s disease. Neurosci Lett 307:122–124.

    Article  PubMed  Google Scholar 

  • Schupf N, Kapell D, Nightingale B, Rodriguez A, Tycko B, Mayeux R (1998) Earlier onset of Alzheimer’s disease in men with Down syndrome. Neurology 50:991–995.

    PubMed  Google Scholar 

  • Schupf N, Pang D, Patel BN, Silverman W, Schubert R, Lai F, Kline JK, Stern Y, Ferin M, Tycko B, Mayeux R (2003) Onset of dementia is associated with age at menopause in women with Down’s syndrome. Ann Neurol 54:433–438.

    Article  PubMed  Google Scholar 

  • Sherwin BB (2002) Estrogen and cognitive aging in women. Trends Pharmacol Sci 23:527–34.

    Article  PubMed  Google Scholar 

  • Shumaker SA, Legault C, Rapp SR, Thal L, Wallace RB, Ockene JK, Hendrix SL, Jones BN, 3rd, Assaf AR, Jackson RD, Kotchen JM, Wassertheil-Smoller S, Wactawski-Wende J, Whims Investigators (2003) Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women’s Health Initiative Memory Study: a randomized controlled trial [see comment]. JAMA 289:2651–2662.

    Article  PubMed  Google Scholar 

  • Sparks DL, Martin TA, Gross DR, Hunsaker JC, 3rd (2000) Link between heart disease, cholesterol, and Alzheimer’s disease: a review. Microsc Res Tech 50:287–290.

    Article  PubMed  Google Scholar 

  • Stone DJ, Rozovsky I, Morgan TE, Anderson CP, Lopez LM, Shick J, Finch CE (2000) Effects of age on gene expression during estrogen-induced synaptic sprouting in the female rat. Exp Neurol 165:46–57.

    Article  PubMed  Google Scholar 

  • Suthers K, Kim JK, Crimmins E (2003) Life expectancywith cognitive impairment in the older population of the United States. J Gerontol B Psychol Sci Soc Sci. 58:S179–S186.

    PubMed  Google Scholar 

  • Tanner C, Hubble J, Chan P (1997) Epidemiology and genetics of Parkinson’s disease. In; Watts R, Koller, W (eds) Movement disorders: neurologic principles and practice.. New York: McGraw-Hill, pp 137–152.

    Google Scholar 

  • Thulin PC, Filoteo V, Roberts JW, O’Brien SA (1998) Effects of hormone replacement therapy on cognitive and motor function in women with Parkinson’s disease. Neurology 50: A280.

    Google Scholar 

  • Van Den Eeden SK, Tanner CM, Bernstein AL, Fross RD, Leimpeter A, Bloch DA, Nelson LM (2003) Incidence of Parkinson’s disease: variation by age, gender, and race/ethnicity. Am J Epidemiol 157:1015–1022.

    Article  PubMed  Google Scholar 

  • vom Saal F, CE F, Nelson J (1994). Natural history of reproductive aging in humans, laboratory rodents, and selected other vertebrates. In: Knobil E (ed) The physiology of reproduction New York: Raven Press, pp 1213–1214

    Google Scholar 

  • Wise PM (2002) Estrogens and neuroprotection. Trends Endocrinol Metab 13:229–230.

    Article  PubMed  Google Scholar 

  • Wise PM, Smith MJ, Dubal DB, Wilson ME, Krajnak KM, Rosewell KL (1999) Neuroendocrine influences and repercussions of the menopause. Endocrinol Rev 20:243–248.

    Article  Google Scholar 

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Authors and Affiliations

  1. Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California, 90089-0191, USA

    Caleb E. Finch, Todd Morgan & Irina Rozovsky

Authors
  1. Caleb E. Finch
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  2. Todd Morgan
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  3. Irina Rozovsky
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Editor information

Editors and Affiliations

  1. Institut Necker, 156, Rue de Vaugirad, 75015, Paris, France

    Claude Kordon Ph.D.

  2. Dept. Medecine Interne, Div. Endocrinologie, Centre Hospitaier Universitaire Vadois, 1011, Lausanne, Switzerland

    Rolf-Christian Gaillard M.D.

  3. Fondation IPSEN, Pour la Recherche Thérapeutique, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Yves Christen Ph.D.

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© 2005 Springer-Verlag Berlin Heidelberg

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Finch, C.E., Morgan, T., Rozovsky, I. (2005). Estrogens, Aging, and Neurodegenerative Diseases. In: Kordon, C., Gaillard, RC., Christen, Y. (eds) Hormones and the Brain. Research and Perspectives in Endocrine Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26940-1_12

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  • DOI: https://doi.org/10.1007/3-540-26940-1_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-21355-0

  • Online ISBN: 978-3-540-26940-3

  • eBook Packages: MedicineMedicine (R0)

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