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Immunomodulation for Corneal Transplantation

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References

  1. http://www. Anzdata. Org. Au/ANZDATA/anzdatawelcome. Htm

    Google Scholar 

  2. Opelz G (1994) Effect of the maintenance immunosuppressive drug regiment on kidney transplant outcome. Transplantation 58:443–446

    PubMed  Google Scholar 

  3. Williams KA, Muehlberg SM, Bartlett CM, Esterman A, Coster DJ (2000) Report from the Australian Corneal Graft Registry 1999. Snap Printing, Adelaide, pp 1–137

    Google Scholar 

  4. Grabner G, Zehetbauer G, Bettelheim H, Honigsmann C, Dorda W (1978) The blood-aqueous barrier and its permeability for proteins of different molecular weight. Graefes Arch Klin Exp Ophthalmol 207:137–148

    Article  Google Scholar 

  5. Dernouchamps JP, Heremans JF (1975) Molecular sieve effect of the blood-aqueous barrier. Exp Eye Res 21:289–297

    Article  PubMed  Google Scholar 

  6. Maurice D, Mishima S (1984) Ocular pharmacokinetics. In: Sears M (ed) Pharmacology of the eye. Springer, Berlin Heidelberg New York, pp 19–116

    Google Scholar 

  7. Kuchle M, Nguyen NX, Naumann GO (1994) Aqueous flare following penetrating keratoplasty and in corneal graft rejection. Arch Ophthalmol 112:354–358

    PubMed  Google Scholar 

  8. Barker CF, Billingham RE (1973) Immunologically privileged sites and tissues. In: Porter R, Knight J (eds) Corneal graft failure. CIBA Foundation Symposium 15 (new series). Elsevier, Amsterdam; Excerpta Medica, North-Holland, pp 79–104

    Google Scholar 

  9. Medawar P (1948) Immunity of homologous grafted skin III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol 29:58–69

    Google Scholar 

  10. Collin HB (1996) Endothelial cell lined lymphatics in the vascularized rabbit cornea. Invest Ophthalmol 5:337–354

    Google Scholar 

  11. Whitsett CF, Stulting RD (1984) The distribution of HLA antigens on human corneal tissue. Invest Ophthalmol Vis Sci 25:519–524

    PubMed  Google Scholar 

  12. Nelken E, Michaelson IC, Nelken D, Gurebitch J (1956) ABO antigens in the human cornea. Nature 177:840

    Google Scholar 

  13. Salisbury JD, Gebhardt BM (1981) Blood group antigens on human corneal cells demonstrated by immunoperoxidase staining. Am J Ophthalmol 91:46–50

    PubMed  Google Scholar 

  14. Katami M, Madden PW, White DJ, Watson PG, Kamada N (1989) The extent of immunological privilege of orthotopic corneal grafts in the inbred rat. Transplantation 41:371–376

    Google Scholar 

  15. Williams KA, Ash JK, Coster DJ (1985) Histocompatability antigen and passenger cell content of normal and diseased human cornea. Transplantation 39:265–269

    PubMed  Google Scholar 

  16. Catry L, Van den Oord J, Foets B, Missotten L (1991) Morphologic and immunophenotypic heterogeneity of corneal dendritic cells. Graefes Arch Clin Ex Ophthalmol 229:182–185

    Google Scholar 

  17. Jager MJ (1992) Corneal Langerhans cells and ocular immunology. Reg Immunol 4:186–195

    PubMed  Google Scholar 

  18. Baudouin C, Brignole F, Pisella PJ, Becquet F, Philip PJ (1997) Immunophenotyping of human dendriform cells from the conjunctival epithelium. Curr Eye Res 16:475–481

    Article  PubMed  Google Scholar 

  19. Liu Y, Hamrah P, Zhang Q, Taylor AW, Dana MR (2002) Draining lymph evidence for major histocompatibility complex (MHC) Class II-positive cells derived from Class II-negative grafts. J Exp Med 195:259–268

    PubMed  Google Scholar 

  20. Hamrah P, Zhang Q, Liu Y, Dana MR (2002) Novel characterization of MHC Class II-negative population of resident corneal Langerhans celltype dendritic cells. Invest Ophthalmol Vis Sci 43:639–646

    PubMed  Google Scholar 

  21. Wilson SE, Li Q, Weng J, Barry-Lane PA, Jester JV, Liang Q et al. (1996) The Fas-Fas ligand system and other modulators of apoptosis in the cornea. Invest Ophthalmol Vis Sci 37:1582–1592

    PubMed  Google Scholar 

  22. Griffith TS, Yu X, Herndon JM, Green DR, Ferguson TA (1996) CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity 5:7–16

    Article  PubMed  Google Scholar 

  23. Stuart PM, Griffith TS, Usui N, Pepose J, Yu X, Fergusin TA (1997) CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival. J Clin Invest 99:396–402

    PubMed  Google Scholar 

  24. Wilbanks GA, Mammolenti M, Streilein JW (1992) Studies on the induction of anterior chamber-associated immune deviation (ACAID), III. Induction of ACAID depends upon intraocular transforming growth factor-beta. Eur J Immunol 22:165–173

    PubMed  Google Scholar 

  25. D'Orazio T, Niederkorn JY (1998) A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol 160:2089–2098

    PubMed  Google Scholar 

  26. Taylor AW, Streilein JW, Cousins SW (1994) Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. Neuroimmunomodulation 1:188–194

    PubMed  Google Scholar 

  27. Taylor AW, Streilein JW, Cousins SW (1994) Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor. J Immunol 153:1080–1086

    PubMed  Google Scholar 

  28. Streilein JW (1996) Peripheral tolerance induction: lessons from immune privileged sites and tissues. Transplant Proc 28:2066–2070

    PubMed  Google Scholar 

  29. Williams KA, Coster DJ (1997) Rethinking immunological privilege: implications for corneal and limbal stem cell transplantation. Mol Med Today 3:495–515

    PubMed  Google Scholar 

  30. Coster DJ (1981) Factors affecting the outcome of corneal transplantation. Ann R Coll Surg Engl 63:91–97

    PubMed  Google Scholar 

  31. Collin HB (1966) Endothelial cell lines lymphatics in the vascularized rabbit cornea. Invest Ophthalmol 5:337–354

    PubMed  Google Scholar 

  32. Cursiefen C, Schlötzer-Schrehardt V, Küchle M et al. (2002) Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. Invest Ophthalmol Vis Sci 43:2127–2135

    PubMed  Google Scholar 

  33. Treselet PA, Foulks GN, Sanfilippo F (1984) The expression of HLA antigens by cells in the human cornea. Am J Ophthalmol 98:763–772

    PubMed  Google Scholar 

  34. Pepose JS, Gardner KM, Nestor MS, Foos RY, Pettit Th (1985) Detection of HLA class I and II antigens in rejected human corneal allografts. Ophthalmology 92:1480–1484

    PubMed  Google Scholar 

  35. Williams KA, White MA, Ash JK, Coster DJ (1989) Leukocytes in the graft bed associated with corneal graft failure. Analysis by immunohistology and actuarial graft survival. Ophthalmology 96:38–44

    PubMed  Google Scholar 

  36. Knop N, Knop E (2000) Conjunctiva-associated lymphoid tissue in the human eye. Invest Ophthalmol Vis Sci 4:1270–1279

    Google Scholar 

  37. Porgador A, Staats HF, Itoh Y, Kelsall BL (1998) Intranasal immunization with cytotoxic T-lymphocyte epitope peptide and mucosal adjuvant cholera toxin: selective augmentation of peptidepresenting dendritic cells in nasal mucosal-associated lymphoid tissue. Infect Immunol 66:5876–5881

    Google Scholar 

  38. Chen H, Hendricks RL (1998) B7 costimulatory requirements of T cells at an inflammatory site. J Immunol 160:5045–5052

    PubMed  Google Scholar 

  39. Klebe S, Sykes P, Coster D, Krishnan R, Williams K (2001) Prolongation of sheep corneal allograft survival by transfer of the gene encoding ovine interleukin 10 to donor corneal endothelium. Transplantation 15:1214–1220

    Article  Google Scholar 

  40. McMenamin PG, Crewe J, Morrison S, Holt PG (1994) Immunomorphologic studies of macrophages and MHC Class II-positive dendritic cells in the iris and ciliary body of the rat, mouse, and human eye. Invest Ophthalmol Vis Sci 35:3234–3250

    PubMed  Google Scholar 

  41. Streilein JW (1996) Peripheral tolerance induction: lessons from immune privileged sites and tissues. Transplant Proc 28:2066–2070

    PubMed  Google Scholar 

  42. Egan RM, Yorkey C, Black R, Loh WK, Stevens JL, Woodward JG (1996) Peptide-specific T cell clonal expansion in vivo following immunization in the eye, an immune-privileged site. J Immunol 157:2262–2271

    PubMed  Google Scholar 

  43. Williamson JS, Di Marco S, Streilein JW (1987) Immunobiology of Langerhans cells on the ocular surface. I Langerhans cells within the central cornea interfere with induction of anterior chamber associated immune deviation. Invest Ophthalmol Vis Sci 28:1527–1532

    PubMed  Google Scholar 

  44. Yamagami S, Dana MR (2001) The critical role of lymph nodes in corneal alloimmunization and graft rejection. Invest Ophthalmol Vis Sci 42:1293–1298

    PubMed  Google Scholar 

  45. Ayliffe W, Alam Y, Bell EB, McLeod D, Hutchinson IV (1992) Prolongation of rat corneal graft survival by treatment with anti-CD4 monoclonal antibody. Br J Ophthalmol 76:602–606

    PubMed  Google Scholar 

  46. Joo CK, Pepose JS, Stuart PM (1995) T-cell mediated responses in a murine model of orthotopic corneal transplantation. Invest Ophthalmol Vis Sci 36:1530–1540

    PubMed  Google Scholar 

  47. Katami M (1995) The mechanisms of corneal graft failure in the rat. Eye 9:197–207

    PubMed  Google Scholar 

  48. Yamada J, Kurimoto I, Streilein JW (1999) Role of CD4+ T cells in immunobiology of orthotopic corneal transplants in mice. Invest Ophthalmol Vis Sci 40:2614–2621

    PubMed  Google Scholar 

  49. Callanan DG, Luckenback MW, Fischer BJ, Peeler JS, Niederkorn JY (1989) Histopathology of rejected orthotopic corenal grafts in the rat. Invest Ophthalmol Vis Sci 30:413–424

    PubMed  Google Scholar 

  50. Larkin DFP, Alexander RA, Cree IA (1997) Infiltrating inflammatory cell phenotypes and apoptosis in rejected human corneal allografts. Eye 11:68–74

    PubMed  Google Scholar 

  51. Kuffova L, Holan V, Lumsden L, Forrester JV, Filipec M (1999) Cell sub-populations in failed human corneal grafts. Br J Ophthalmol 83:1364–1369

    PubMed  Google Scholar 

  52. Matoba AY, Peeler JS, Niederkorn JY (1986) T cell subsets in the immune rejection of murine heterotopic corneal allografts. Invest Ophthalmol Vis Sci 27:1244–1254

    PubMed  Google Scholar 

  53. Hegde S, Niederkorn JY (2000) The role of cytotoxic T lymphocytes in corneal allograft rejection. Invest Ophthalmol Vis Sci 41:3341–3347

    PubMed  Google Scholar 

  54. Jager MJ, Volker-Dieben HJ, Vos A, Broersma L, Kok FG, van der Gaag R (1991) Cellular and humoral anticorneal immune response in corneal transplantation. Arch Ophthalmol 109:972–977

    PubMed  Google Scholar 

  55. Hutchinson IV, Alam Y, Ayliffe WR (1995) The humoral response to an allograft. Eye 9:155–160

    PubMed  Google Scholar 

  56. Goslings WR, Yamada J, Dana MR et al. (1999) Corneal transplantation in antibody-deficient hosts. Invest Ophthalmol Vis Sci 40:250–253

    PubMed  Google Scholar 

  57. Tuft SJ, Coster DJ (1990) The corneal endothelium. Eye 4:389–424

    PubMed  Google Scholar 

  58. The Collaborative Corneal Transplantation Studies Research Group (1992) The collaborative corneal transplantation studies (CCTS). Effectiveness of histocompatibility matching in highrisk corneal transplantation. Arch Ophthalmol 110:1392–1403

    Google Scholar 

  59. Hopkins KA, Maguire MG, Fink NE, Bias WB (1992) Reproducibility of HLA-A,-B, and-DR typing using peripheral blood samples; results of retyping in the collaborative corneal transplant studies. Corneal Transplantation Studies Group (corrected). Hum Immunol 33:122–128

    Article  PubMed  Google Scholar 

  60. Batchelor JR, Casey TA, Werb A, et al. (1976) HLA matching and corneal grafting. Lancet 1:551–554

    Article  PubMed  Google Scholar 

  61. Volker-Dieben HJ, Kok-van Alphen CC, Lansbergen Q, Persijn GG (1982) The effect of prospective HLA-A and-B matching and corneal graft survival. Acta Ophthalmol (Copenhagen) 60:203–212

    Google Scholar 

  62. Gore SM, Vail A, Bradley VA, Rogers CA, Easty DL, Armitage WJ (1995) HLA-DR matching in corneal transplantation. Systemic review of published evidence. Corneal Transplant Follow-up Study Collaborators. Transplantation 60:1033–1039

    PubMed  Google Scholar 

  63. Foulks GN, Sanfilippo FP, Locascio JA III, Mac-Queen JM, Dawson DV (1983) Histocompatability testing for keratoplasty in high-risk patients. Ophthalmology 90:230–244

    PubMed  Google Scholar 

  64. Sanfilippo F, MacQueen JM, Vaughn WK, Foulks GN (1986) Reduced graft rejection with good HLA-A and B matching in high-risk corneal transplantation. N Engl J Med 315:29–35

    PubMed  Google Scholar 

  65. Hoffman F, von Keyserlingk HJ, Wiederholt M (1986) Importance of HLA DR matching for corneal transplantation in high-risk cases. Cornea 5:139–143

    PubMed  Google Scholar 

  66. Khaireedin R, Wachtlin J, Hopfenmüller W, Hoffman F (2003) HLA-A, HLA-B, and HLA-DR matching reduces the rate of corneal allograft rejection. Graefes Arch Clin Exp Ophthalmol 241:1020–1028

    Article  PubMed  Google Scholar 

  67. Baggesen K, Lamm LU, Ehlers N (1996) Significant effect of high-resolution HLA-DRB1 matching in high-risk corneal transplantation. Transplantation 62:1273–1277

    Article  PubMed  Google Scholar 

  68. Munkhbat B, Hagihara M, Sato T, et al. (1997) Association between HLA-DPB1 matching and 1-year rejection-free graft survival in high-risk corneal transplantation. Transplantation 63:1011–1016

    Article  PubMed  Google Scholar 

  69. Vail A, Gore SM, Bradley BA, Easty DL, Rogers CA, Armitage WJ (1994) Influence of donor and histocompatibility factors on corneal graft outcome. Transplantation 58:1210–1216

    PubMed  Google Scholar 

  70. Morris PJ (1996) A critical review of immunosuppressive regimens. Transplant Proc 28(Suppl):37–40

    PubMed  Google Scholar 

  71. Abrahams C, Gaillard V (1980) Instillation of steroids in the eye: its effect on lymphocytes in regional lymph nodes and in peripheral blood. S Afr Med J 57:993–995

    PubMed  Google Scholar 

  72. Meyer PA, Watson PG, Franks W, Dubord P (1987) 'Pulsed’ immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. Eye 1:487–495

    PubMed  Google Scholar 

  73. Silverman ED, Myones BL, Miller JJ 3rd (1984) Lymphocyte sub-population alterations induced by intravenous megadose pulse methylprednisolone. J Rheumatol 11:287–290

    PubMed  Google Scholar 

  74. Zweiman B, Atkins PC, Bedard PM, Flaschen SL, Lisak RP (1984) Corticosteroid effects on circulating lymphocyte subset levels in normal humans. J Clin Immunol 4:151–155

    Article  PubMed  Google Scholar 

  75. Berge RJ, Sauerwein HP, Yong SL, Schellekens PT (1984) Administration of prednisolone in vivo affects the ratio of OKT4/OKT8 and the LDHisoenzyme pattern of human T lymphocytes. Clin Immunol Immunopathol 30:91–103

    Article  PubMed  Google Scholar 

  76. Hill JC, Maske R, Watson P (1991) Corticosteroids in corneal graft rejection. Oral versus single pulse therapy. Ophthalmology 98:329–333

    PubMed  Google Scholar 

  77. Hill JC, Ivey A (1994) Corticosteroids in corneal graft rejection; double versus single pulse therapy. Cornea 13:383–388

    PubMed  Google Scholar 

  78. Lam DS, Wong AK, Tham CC, Leung AT (1998) The use of combined intravenous pulse methylprednisolone and oral cyclosporine A in the treatment of corneal graft rejection: a preliminary study. Eye 12:615–618

    PubMed  Google Scholar 

  79. Hudde T, Minassian DC, Larkin DF (1999) Randomized controlled trial of corticosteroid regimens in endothelial corneal graft rejection. Br J Ophthalmol 83:1348–1352

    PubMed  Google Scholar 

  80. Thompson JF, Chalmers DH, Wood RF, Kirkham SR, Morris PJ (1983) Sudden death following high-dose intravenous methylprednisolone. Transplantation 36:594–596

    PubMed  Google Scholar 

  81. Mackay IR, Bignell JL, Smith PH, Crawford BA (1967) Prevention of corneal graft failure with the immunosuppressive drug azothioprine. Lancet 2:479–482

    Article  PubMed  Google Scholar 

  82. Reinhard T, Reis A, Bohringer D, Malinowski M, Voiculescu A, Heering P, Godehardt E, Sunmacher R (2001) Systemic mycophenolate motefil in comparison with systemic cyclosporin A in highrisk keratoplasty patients: 3 years' results of randomized prospective clinical trial. Graefes Arch Clin Exp Ophthalmol 239:367–372

    PubMed  Google Scholar 

  83. Hogan PG, Chen L, Nardone J, Rao A (2003) Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 17:2205–2232

    Article  PubMed  Google Scholar 

  84. Shepherd WFI, Coster DJ, Chin Foog TC, Rice NSC, Jones BR (1980) Effect of cyclosporin A on the survival of corneal grafts in rabbits. Br J Ophthalmol 64:148–153

    PubMed  Google Scholar 

  85. Zhang EP, Schulte F, Bulfone-Paus S, Hoffman F (2000) The effect of corticosteroid and cyclosporin A on murine corneal allograft rejection. Graefes Arch Clin Exp Ophthalmol 238:525–530

    PubMed  Google Scholar 

  86. Claerhout I, Beele H, Verstraete A, Van den Broecke C, Kestelyn P (2001) The effect of duration and timing of systemic cyclosporine therapy on corneal allograft survival in a rat model. Graefes Arch Clin Exp Ophthalmol 23:152–157

    Google Scholar 

  87. Hill JC (1994) Systemic cyclosporin in high-risk keratoplasty. Short-term versus long-term therapy. Ophthalmology 101:12833

    Google Scholar 

  88. Hill JC (1995) Systemic cyclosporin in high-risk keratoplasty: long-term results. Eye 9:422–428

    PubMed  Google Scholar 

  89. Sundmacher R, Reinhard T, Heering P (1992) Six years' experience with systemic cyclosporin A prophylaxis in high-risk perforating keratoplasty patients. A retrospective study. Ger J Ophthalmol 1:432–436

    PubMed  Google Scholar 

  90. Poon AC, Forbes JE, Dart JK, Subramaniam S, Bunce C, Madison P, Ficker LA, Tuft SJ, Gartry DS, Buckley RJ (2001) Systemic cyclosporin A in high-risk penetrating keratoplasties: a case-control study. Br J Ophthalmol 85:1465–1469

    Google Scholar 

  91. Inoue K, Kimura C, Amano S, Sato T, Fujjita N, Kagayo F, Kaji Y, Tsuru T, Araie M (2001) Long-term outcome of cyclosporine treatment following penetrating keratoplasty. Jpn J Ophthalmol 45:378–382

    Article  PubMed  Google Scholar 

  92. Rumelt S, Berdusky V, Blum-Hareuveni T, Rehany V (2002) Systemic cyclosporin A in high failure risk, repeated corneal transplantation. Br J Ophthalmol 86:988–992

    Article  PubMed  Google Scholar 

  93. Algros MP, Angonin R, Delbose B, Cahn JY, Kantelip B (2002) Danger of systemic cyclosporin for corneal grafts. Cornea 21:613–614

    Article  PubMed  Google Scholar 

  94. Ippoliti G, Fronterre A (1987) Use of locally injected anti-T monoclonal antibodies in the treatment of acute corneal graft rejection. Transplant Prod 19:2579–2580

    Google Scholar 

  95. Ippoliti G, Fronterre A (1989) Usefulness of CD3 or CD6 anti-T monoclonal antibodies in the treatment of acute corneal graft rejection. Transplant Proc 21:3133–3134

    PubMed  Google Scholar 

  96. Newman DK, Isaacs JD, Watson PG, Meyer PA, Hale G, Waldmann H (1995) Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H. Eye 9:564–569

    PubMed  Google Scholar 

  97. Dick AD, Meyer P, James T, Forrester JV, Hale G, Waldmann H, et al. (2000) Campath-1H therapy in refractory ocular inflammatory disease. Br J Ophthalmol 84:107–109

    Article  PubMed  Google Scholar 

  98. Schmitz K, Hitzer S, Behrens-Baumann W (2002) Immune suppression by combination therapy with basiliximab and cyclosporin in high risk keratoplasty. A pilot study. Ophthalmology 99:38–45

    Google Scholar 

  99. Thiel MA, Coster DJ, Williams KA (2003) The potential of antibody-based immunosuppressive agents for corneal transplantation. Immunol Cell Biol 81:93–105

    Article  PubMed  Google Scholar 

  100. Thiel MA, Coster DJ, Standfield SD, et al. (2002) Penetration of engineered antibody fragments into the eye. Clin Exp Immunol 128:67–74

    Article  PubMed  Google Scholar 

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Coster, D.J., Williams, K.A. (2005). Immunomodulation for Corneal Transplantation. In: Krieglstein, G.K., Weinreb, R.N., Pleyer, U., Mondino, B. (eds) Uveitis and Immunological Disorders. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26752-2_4

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