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Isoquinolinesulfonamide: A Specific Inhibitor of Rho-Kinase and the Clinical Aspect of Anti-Rho-Kinase Therapy

  • Chapter
Inhibitors of Protein Kinases and Protein Phosphates

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 167))

Abstract

The light of molecular pharmacology research has been focused on protein kinase inhibitor sulfonamide derivatives since 1978. Our studies on naphthalene and isoquinoline sulfonamide derivatives over the last 25 years have achieved a pronounced contribution toward elucidating the physiological function of various protein kinases and, moreover, toward developing a new type of medicine. This chapter relates to the discovery of new protein kinase inhibitors, their mechanisms of action, and their clinical application in Japan.

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Author information

Authors and Affiliations

  1. Western Therapeutics Institute, 100-32 Yagotohonmachi, Showa-ku, 466-0825, Nagoya, Japan

    H. Hidaka

  2. Department of Neurosurgery, Nagoya Daini Red Cross Hospital, 2-9 Myoken, Showa-ku, 466-8650, Nagoya, Japan

    Y. Suzuki

  3. Chukyo Hospital, 1-1-10 Sanjo, Minami-ku, 457-8510, Nagoya, Japan

    M. Shibuya

  4. Department of Pharmacology, Pharmaceutical Science, Kitasato University, 5-9-1 Shirokane, Minato-ku, 108-8641, Tokyo, Japan

    Y. Sasaki

Authors
  1. H. Hidaka
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  2. Y. Suzuki
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  3. M. Shibuya
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  4. Y. Sasaki
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Editor information

Editors and Affiliations

  1. Dipartimento di Chimica Biologica, Università di Padova, Via Trieste 75, Padova, 35121, Italy

    Lorenzo A. Pinna

  2. MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, MSI/WTB Complex, Dow St., Dundee, DD1 5EH, Scotland, UK

    Patricia T.W. Cohen Ph.D. (Professor of Molecular Biology) (Professor of Molecular Biology)

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© 2005 Springer-Verlag

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Hidaka, H., Suzuki, Y., Shibuya, M., Sasaki, Y. (2005). Isoquinolinesulfonamide: A Specific Inhibitor of Rho-Kinase and the Clinical Aspect of Anti-Rho-Kinase Therapy. In: Pinna, L.A., Cohen, P.T. (eds) Inhibitors of Protein Kinases and Protein Phosphates. Handbook of Experimental Pharmacology, vol 167. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26670-4_15

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