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References
Aronoff S (1965) Catalase: kinetics of photo-oxidation. Science 150: 72–73
Austin LM, Boissy RE (1995) Mammalian tyrosinase related protein-1 is recognised by autoantibodies from vitiliginous Smyth chickens. Am J Pathol 146:1529–1541
Baharav E, Merimski O, Shoenfeld Y, Zigelman R, Gilbrud B, Yecheskel G, Youinou P, Fishman P (1996) Tyrosinase as an autoantigen in patients with vitiligo. Clin Exp Immunol 105: 84–88
Beazley WD, Gaze DC, Panske A, Panzig E, Schallreuter KU (1999) Serum selenium levels and glutathione peroxidase activities in vitiligo. Br J Dermatol 141: 301–303
Bhawan J, Bhutani LK (1983) Keratinocyte damage in vitiligo. J Cutaneous Path 10: 207–212
Blau N, Barnes I, Dhondt JL (1996) International database of tetrahydrobiopterin deficiences. J Inherit Metab Dis 19: 8–14
Boissy R, Liu YY, Medrano EE, Nordlund JJ (1991) Structural aberration of the rough endoplasmic reticulum and melanosome compartmentalisation in long term cultures of melanocytes from vitiligo patients. J Invest Dermatol 97: 395–404
Boissy RE, Sakai C, Zhao H, Kobayashi T, Hearing VJ (1998) Human tyrosinase related protein-1 (TRP-1). Exp Dermatol 7: 198–204
Boissy RE, Manga P (2004) On the etiology of contact/occupational vitiligo. Pigment Cell Res 17: 208–14
Calanchini-Postizzi E, Frenk E (1987) Long-term actinic damage in sun-exposed vitiligo and normally pigmented skin. Dermatologica 174: 266–71
Casp CB, She JX, McCormack WT (2002) Genetic association of the catalase gene (CAT) with vitiligo susceptibility. Pigment Cell Res 15: 62–6
Cui J, R Harning, M Henn, J-C Bystryn (1992) Identification of pigment cells antigens defined by vitiligo antibodies. J Invest Dermatol 98: 162–165
Cui J, Arita Y, Bystryn J-C (1993) Cytolytic antibodies to melanocytes in vitiligo. J Invest Dermatol 100: 812–815
Cui J, Chen D, Misfeldt ML, Swinfard RW, Bystryn J-C (1995) Antimelanoma antibodies in swine with spontaneously regressing melanoma. Pigment Cell Res 8: 60–63
Darr D, Fridovich I (1994) Free radicals in cutaneous biology. J Invest Dermatol 102: 671–675
Davis MD, Ribeiro P, Tipper J, Kaufman S (1992) 7-Tetrahydrobiopterin, a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydrolases. Proc Natl Acad Sci USA 89: 10108–10113
De la Fuente-Fernandez R (1997) Mutations in GTP-cyclohydrolase I gene and vitiligo. Lancet 350: 640
Diehle J (2004) Med Thesis, University of Hamburg, Germany
Galbraith GM, Miller D, Emerson DL (1988) Western blot analysis of serum antibody reactivity with human melanoma cell antigens in alopecia areata and vitiligo. Clin Immunol Immunopathol 48: 317–324
Grimes PE, Sevall JS, Vojdani A (1996) Cytomegalovirus DNA identified in skin biopsy specimens of patients with vitiligo. J Am Acad Dermatol 1996; 35:21–26
Grimes PE, Elkadi T, Sanders, J (1999) Epstein-Barr virus infection in patients with vitiligo (abstr). J Invest Dermatol 112: 604
Halaban R, Moellmann GE (1990) Murine and human b-locus pigmentation genes encode a glycoprotein (gp75) with catalase activity. Proc Nat Acad Sci USA 1990 87:4809–4813
Hamzavi I, Jain H, Mclean D, Shapiro J, Zeng H, Lui H (2004) Parametric modelling of narrowband UVB phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. Arch Dermatol 140: 677–83
Harning R, Cui J, Bystryn J-C (1991) Relation between the incidence and level of pigment cell antibodies and disease activity in vitiligo. J Invest Dermatol 97: 1078–1080
Hasse S, Gibbons NC, Rokos H, Marles LK, Schallreuter KU (2004) Perturbed 6-tetrahydrobi-opterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress. J Invest Dermatol 122: 307–313
Herrath MG, Oldstone MB (1996) Virus induced autoimmune disease. Curr Opin Immunol 8:878–885
Jimbow K, Chen H, Park JS, Thomas P (2001) Increased sensitivity of melanocytes to oxidative stress and abnormal expression of tyrosinase related protein in vitiligo. Br J Dermatol 144: 55–65
Kemp EH, Gawkrodger DJ, MacNeil S, Watson PF, Weetman AP (1997a) Detection of tyrosinase autoantibodies in vitiligo patients using 35S-labelled recombinant human tyrosinase in a radioimmunoassay. J Invest Dermatol 109: 69–73
Kemp EH, Gawkrodger DJ, Watson PF, Weetman AP (1997b) Immunoprecipitation of melanogenic enzyme autoantigens with vitiligo sera: evidence for cross-reactive autoantibodies to tyrosinase and tyrosinase-related protein-2 (TRP-2). Clin Exp Immunol 109:495–500
Kemp EH, Waterman, Gawkrodger DJ, Watson PF, Weetman AP (1998) Autoantibodies to tyrosinase-related protein-1 (TRP-1) detected in the sera of vitiligo patients using a quantitative radiobinding assay. Br J Dermatol 139: 798–805
Kemp EH, Waterman EA, Gawkrodger DJ, Watson PF, Weetman AP (1999) Identification of epitopes on tyrosinase which are recognised by autoantibodies from patients with vitiligo. J Invest Dermatol 113: 267–271
Kwon BS (1993) Pigmentation genes: the tyrosinase gene family and the pmell7 gene family. J Invest Dermatol 100: 134S–140S
Laihia JK, Jansen CT (1997) Upregulation of human epidermal Langerhans cell B7-1 and B7-2 costimulatory molecules in vivo by solar stimulating irradiation. Eur J Immunol 27:984–989
Laskin JD, Piccinini LA (1986) Tyrosinase isozyme heterogeneity in differentiating B16/C3 melanoma. J Biol Chem 261: 16626–16635
LePoole IC, Das PK, van den Wijngaard RM, Bos JD, Westerhof W (1993a) Review of the etiopathomechanism of vitiligo: A convergence theory. Exp Dermatol 2: 146–153
LePoole IC, van dan Wijngaard RM, Westerhof W, Dutrieux RP, Das PK (1993b) Presence or absence of melanocytes in vitiligo lesions: an immunohistochemical investigation. J Invest Dermatol 100: 816–822
LePoole C, Wijngaard Van den, Smit NPM, Oosting J, Westerhof W, Pavel S (1994) Catechol-O-methyl transferase in vitiligo. Arch Dermatol Res 286: 81–86
Le Poole IC, Wankowicz-Kalinska A, van der Wijngaard RMJGJ, Nickoloff BJ, Das PK (2004) Autoimmune aspects of depigmentation in vitiligo. J Invest Dermatol Symp Proc 9: 68–72
Manga P, Sato K, Ye L, Beerman F, Lamoreux ML, Orlow SJ (2000). Mutational analysis of the modulation of tyrosinase by tyrosinase related proteins 1 and 2 in vitro. J Pigment Cell Res 13: 364–374
Maresca V, Roccella M, Roccella F, Camera E, Del Porto G, Passi S, Grammatico P, Picardo M (1997) Increased sensitivity to peroxidative agents as a possible pathogenic factor of melanocyte damage in vitiligo. J Invest Dermatol 109: 310–313
Marks DB, Marks AD, Smith CM (1996) Oxygen metabolism and oxygen toxicity. In: Basic Medical Biochemistry: A Clinical Approach. Baltimore: Williams and Wilkins 327–340
Marles LK, Peters EM, Tobin DJ, Hibberts NA, Schallreuter KU (2003) Tyrosine hydroxylase isoenzyme I is present in human melanosomes: a possible novel function in pigmentation. Exp Dermatol 12: 61–70
Medrano EE and Nordlund JJ (1990) Successful culture of adult human melanocytes obtained from normal and vitiligo donors. J Invest Dermatol 95: 441–445
Moellmann G, Klein-Angerer S, Scollay DA, Nordlund JJ, Lerner AB (1982) Extracellular granular material and degeneration of keratinocytes in the normally pigmented epidermis of patients with vitiligo. J Invest Dermatol 79: 321–330
Moretti S, Spallanzani A, Amato L et al. (2002) New insights into the pathogenesis of vitilgo: imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res 15: 87–92
Morrone A, Picardo M, De Luca C, Terminali O, Passi S, Ippolito F (1992) Catecholamines and vitiligo. Pigment Cell Res 5: 58–62
Morse SS, Sakaguchi N, Sakaguchi S (1999) Virus and autoimmunity: induction of autoimmune disease in mice by mouse T-lymphotropic virus (MTLV) destroying CD4 and T cells. J Immunol 162: 5309–5316
Naughton GK, Eisinger M, Bystryn J-C (1983a) Antibodies to normal human melanocytes in vitiligo. J Exp Med 158: 246–251
Naughton GK, Eisinger M, Bystryn J-C (1983b) Detection of antibodies to melanocytes in vitiligo by specific immunoprecipitation. J Invest Dermatol 81: 540–542
Naughton GK, Reggiardo MD, Bystryn J-C (1986a) Correlation between vitiligo antibodies and extent of depigmentation in vitiligo. J Am Acad Dermatol 15: 978–981
Naughton GK, Mahaffey M, Bystryn J-C (1986b) Antibodies to surface antigens of pigment cells in animals with vitiligo. Proc Soc Exp Biol Med 181: 423–426
Nordlund JJ, Ortonne JP (1992) Vitiligo and depigmentation. Curr Prob Dermatol 4: 3–30
Nordlund JJ, Boissy RE, Hearing VJ, King RA, Ortonne JP (eds) (1998) The pigmentary system. Physiology and Pathophysiology. Oxford University Press, Oxford
Norris DA, Kissinger RM, Naughton GK, Bystryn J-C (1998) Evidence for immunologic mechanisms in human vitiligo: patients’ sera induce damage to human melanocytes in vitro by complement-mediated damage and antibody-dependent cellular toxicity. J Invest Dermatol 90: 783–789
Okamoto T, Irie RF, Fujii S, Huang SKS, Nizze AJ, Morton DL, Hoon DSB (1998) Anti-tyrosinase related protein-2 immune response in vitiligo patients and melanoma patients receiving active-specific immunotherapy. J Invest Dermatol 111: 1034–1039
Orlow SJ, Boissy RE, Moran D, Pifka-Hinst S (1993) Subcellular distribution of tyrosinase and tyrosinase related protein 1: Implications for melanosomal biogenesis. J Invest Dermatol 100:55–64
Ortonne JP, Bose SK (1993) Vitiligo: Where do we stand? Pigment Cell Res 8: 61–72
Rokos H, Beazley WD, Schallreuter KU (2002) Oxidative stress in vitilgo: photo-oxidation of pterins produces H2O2 and pterin-6-carboxylic acid. Biochem Biophys Res Commun 292:805–11
Rokos H, Moore J, Hasse S, Gillbro JM, Wood JM, Schallreuter KU (2004) In vivo Fluorescence Excitation Spectroscopy and in vivo FT-Raman Spectroscopy in human skin: Evidence of H2O2 oxidation of epidermal albumin in patients with vitiligo. J Raman Spectrosc 35: 125–130
Rutault K, Alderman C, Chain BM, Katz DR (1999) Reactive oxygen species activate human peripheral blood dendritic cells. Free Radic Biol Med 26: 232–238
Schallreuter KU, Pittelkow MR (1988) Defective calcium uptake in keratinocyte cell cultures from vitiliginous skin. Arch Dermatol Res 280: 137–139
Schallreuter KU, Wood JM, Berger J (1991) Low catalase levels in the epidermis of patients with vitiligo. J Invest Dermatol 97: 1081–1085
Schallreuter KU, Wood JM, Pittelkow MR, Gütlich M, Lemke KR, Rödl W, Swanson NN, Hitzemann K, Ziegler I (1994a) Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin. Science 263: 1444–1446
Schallreuter KU, Wood JM, Ziegler I, Lemke KR, Pittelkow MR, Lindsey NJ, Gütlich M (1994b) Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo. Biochim Biophys Acta 1226: 181–192
Schallreuter KU, Büttner G, Pittelkow MR, Wood JM, Swanson NN, Körner C (1994c) Cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Communs 204:43–48
Schallreuter KU, Wood JM, Lemke KR, Levenig C (1995a) Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB exposure: a case study on 33 patients. Dermatol 190: 223–229
Schallreuter KU, Lemke KR, Pittelkow MR, Wood JM, Körner C, Malik R (1995b) Catecholamines and keratinocyte differentiation. J Invest Dermatol 104: 953–957
Schallreuter KU, Wood JM, Pittelkow MR, Büttner G, Swanson NN, Körner C, Ehrke C (1996a) Increased monoamine oxidase A activity in the epidermis of patients with vitiligo. Arch Dermatol Res 288: 14–18
Schallreuter KU, Pittelkow MR, Swanson NN (1996b) Defective calcium transport in vitiliginous melanocytes. Arch Dermatol Res 288: 11–13
Schallreuter KU, Blau N (1997) GTP-cyclohydrolase and vitiligo. Lancet 350: 1254
Schallreuter KU, Zschiesche M, Moore J, Panske A, Hibberts NA, Herrmann FH, Metelmann HR, Sawatzki J (1998) In vivo evidence for compromised phenylalanine metabolism in vitiligo. Biochem Biophys Res Commun 243: 395–399
Schallreuter KU, Moore J, Wood JM, Beazley WD, Gaze DC, Tobin DJ, Marshall HS, Panske A, Panzig E, Hibberts NA (1999a) In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. J Invest Dermatol Symp Proc4: 91–96
Schallreuter KU (1999b). Successful treatment of oxidative stress in vitiligo. Skin Pharmacol Appl Skin Physiol 12: 132–138
Schallreuter KU, Wood JM (1999c) The importance of L-phenylalanine transport and its autocrine turnover to L-tyrosine for melanogenesis in human epidermal melanocytes. Biochem Biophys Res Commun 262: 423–428
Schallreuter KU, Moore J, Wood JM, Beazley WD, Peters EMJ, Marles LK, Behrens-Williams SC, Dummer R, Blau N, Thöny B (2001) Epidermal H2O2 accumulation alters tetrahydrobiopterin (6BH4) recycling in vitiligo: Identification of a general mechanism in regulation of all 6BH4, dependent processes? J Invest Dermatol 116: 167–74
Schallreuter KU, Tobin DJ, Panske A (2002) Decreased photodamage and low incidence of non-melanoma skin cancer in 136 sun-exposed caucasian patients with vitiligo. Dermatology 204: 194–201
Schallreuter KU, Behrens-Williams S, Khaliq TP et al. (2003) Increased epidermal functioning wild-type p53 expression in vitiligo. Exp Dermatol 12: 268–277
Schallreuter KU, Elwary SM, Gibbons NC, Rokos H, Wood JM (2004) Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun 315: 502–508
Shimizu S, Shiota K, Yamamoto S et al. (2003) Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases ntric oxide synthase activity in vascular endothelial cells. Free Radic Biol Med 34: 1343–52
Song Y, Connor E, Li Y, Zorovich B, Balducci P, Maclaren N (1994) The role of tyrosinase in autoimmune vitiligo. Lancet 344: 1049–1052
Spritz RA, Gowan K, Bennett DC, Fain PR (2004) Novel vitiligo susceptibility loci on chromosomes 7 (AIS2) and 8 (AIS3), confirmation of SLEV1 on chromosome 17, and their roles in an autoimmune diathesis. Am J Hum Genet 74: 188–91
Stark JM(1998) Immunological adjuvance of metabolic origin: oxidative stress, postulated impaired function of thiol proteases and immunogenicity. Scand J Immunol 48: 475–479
Tobin DJ, Swanson NN, Pittelkow MR, Peters EMJ, Schallreuter KU (2000) Melanocytes are not absent in lesional skin of long duration vitiligo. J Pathol 2000 191: 407–416
Vile GF (1997) Active oxygen species mediate the solar ultraviolet radiation-dependent increase in the tumour suppressor protein p53 in human skin fibroblasts. FEBS Lett 412: 70–74
Westerhof W, Nieuweboer-Krobotova L, Mulder PG, Glazenburg EJ (1999) Left-right comparison study of the combination of fluticasone propionate and UVA vs either fluticasone propionate or UVA alone for the long term treatment of vitiligo. Arch Dermatol 135:1061–6
Wood JM, Schallreuter KU (1991) Studies on the reactions between human tyrosinase, superoxide anion, hydrogen peroxide and thiols. Biochim Biophys Acta 1074: 378–385
Wood JM, Jimbow K, Boissy RE, Slominski A, Plonka PM, Slawinski J, Wortsman J, Tosk J (1999) What’s the use of generating melanin? Exp Dermatol 8: 133–164
Würfel F, Panske A, Schallreuter KU (2000) Are viral infections a possible cause for the manifestation of vitiligo? J Pigment Cell Res 13: 404
Xie Z, Chen D, Jiao D, Bystryn J-C (1999) Vitiligo antibodies are not directed to tyrosinase. Arch Dermatol 135: 417–422
Yohn JJ, Norris DA, Yrastorza G, Buno IJ, Leff JA, Hake SS, Repine JE (1991) Disparate antioxidant enzyme activities in cultured human cutaneous fibroblasts, keratinocytes and melanocytes. J Invest Dermatol 97: 405–409
Yokoyama K, Suzuki H, Yasumoto K, Tomita Y, Shibahara S (1994) Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2. Biochim Biophys Acta 1217: 317–321
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Schallreuter, K.U. (2005). Vitiligo. In: Hertl, M. (eds) Autoimmune Diseases of the Skin. Springer, Vienna. https://doi.org/10.1007/3-211-27377-8_18
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