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Pathogenesis and Therapy of Rheumatoid Arthritis

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Book cover Tissue-Specific Estrogen Action

Part of the book series: Ernst Schering Foundation Symposium Proceedings ((SCHERING FOUND,volume 2006/1))

Abstract

Rheumatoid arthritis is a chronic disabling disease affecting at least 1% of the population on a worldwide basis. Research aimed at understanding the pathogenesis of this disease led to the identification of TNFα as a major pro-inflammatory cytokine expressed in the inflamed joints of patients with rheumatoid arthritis. Subsequently, in vitro studies provided evidence to suggest that TNFα played an important role in driving the expression of additional pro-inflammatory cytokines, such as IL-1, GM-CSF, IL-6, and IL-8, in synovial cell cultures. Another important finding that confirmed the pathological significance of TNFα was that mice genetically engineered to overexpress TNFα spontaneously developed arthritis. Subsequently, the therapeutic effect TNFα blockade was tested in animal models prior to clinical trials in human patients, which provided unequivocal verification of the validity of TNFα as a therapeutic target. Anti-TNFα therapy is now accepted as a fully-validated treatment modality for rheumatoid arthritis.

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Acknowledgements

This work was supported by the Arthritis Research Campaign (ARC) of Great Britain.

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  1. Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, W6 8LH, London, UK

    R. O. Williams

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K. S. Korach T. Wintermantel

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Williams, R.O. (2007). Pathogenesis and Therapy of Rheumatoid Arthritis. In: Korach, K.S., Wintermantel, T. (eds) Tissue-Specific Estrogen Action. Ernst Schering Foundation Symposium Proceedings, vol 2006/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/2789_2006_019

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