Skip to main content

High-Resolution CT of the Lung in Children: Clinical Applications

  • Chapter
  • First Online:
  • 2588 Accesses

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

High-Resolution CT of the Lung in children: Clinical Applications (HRCT) of the chest allows a detailed structural assessment of secondary pulmonary lobules and intrapulmonary interstitium, Based on characteristic patterns and distribution of pathology, it has proved to be of great value for the diagnosis and management of adult patients with lung disease. More recently in the pediatric population HRCT was also recognized to be a valuable tool for exploring lung diseases. Airway diseases and air-space disease are now well known and described. In the recent past, progresses were done in the comprehension of pediatric interstitial lung disease. In the pediatric population, a developmental or genetic origin could be shown. So, classification of interstitial lung disease is now specific to the pediatric population. In this chapter we revisited well-known pediatric lung diseases and introduced notions about the newest childhood interstitial lung diseases.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Abbott GF, Rosado-de-Christenson ML, Franks TJ et al (2004) Pulmonary Langerhans cell histriocytosis. Radiographics 24:821–841

    PubMed  Google Scholar 

  • Abehsera M, Valeyre D, Grenier P et al (2000) Sarcoidosis with pulmonary fibrosis: CT patterns and correlation with pulmonary function. AJR 174:1751–1757

    CAS  PubMed  Google Scholar 

  • Agarwal R, Khan A, Garg M et al (2012) Chest radiographic and computed tomographic manifestations in allergic bronchopulmonary aspergillosis. World J Radiol 28:141–150

    Google Scholar 

  • Akira M, Yamamoto S, Sakatani M (1998) Bronchiolitis obliterans organizing pneumonia manifesting as multiple large nodules or masses. AJR 170:291–295

    CAS  PubMed  Google Scholar 

  • Albafouille V, Sayegh N, de Coudenhove S et al (1999) CT scan patterns of pulmonary alveolar proteinosis in children. Pediatr Radiol 29:147–152

    CAS  PubMed  Google Scholar 

  • Altamirano HG, McGeady SJ, Mansmann HC (1991) Right middle lobe syndrome in asthmatic children. Pediatr Asthma Allergy Immunol 5:33–37

    Google Scholar 

  • Amorosa JK, Miller RW, Laraya-Cuasay L et al (1992) Bronchiectasis in children with lymphocytic interstitial pneumonia and acquired immune deficiency syndrome. Pediatr Radiol 22:603–607

    CAS  PubMed  Google Scholar 

  • Aquino SL, Schechter MS, Chiles C et al (1999) High-resolution inspiratory and expiratory CT in older children and adults with bronchopulmonary dysplasia. AJR 173:963–967

    CAS  PubMed  Google Scholar 

  • Arslan N, Ilgan S, Ozkan M et al (2001) Utility of ventilation and perfusion scan in the diagnosis of young military recruits with an incidental findings of hyperlucent lung. Nucl Med Commun 22:525–530

    CAS  PubMed  Google Scholar 

  • Aukland SM, Rosendahl K, Owens CM et al (2009) Neonatal bronchopulmonary dysplasia predicts abnormal pulmonary HRCT scans in long-term survivors of extreme preterm birth. Thorax 64:405–410

    CAS  PubMed  Google Scholar 

  • Aydin K, Karabulut N, Demirkazik F et al (1997) Pulmonary involvement in adult Gaucher’s disease: high-resolution CT appearance. Br J Radiol 70:93–95

    CAS  PubMed  Google Scholar 

  • Bandeira T, Negreiro F, Ferreira R et al (2011) Clinical, radiological, and physiological differences between obliterative bronchiolitis and problematic severe asthma in adolescents and young adults: the early origins of the overlap syndrome? Pediatr Pulmonol 46:573–580

    PubMed  Google Scholar 

  • Bankier AA, van Muylen A, Knoop C et al (2001) Bronchiolitis obliterans syndrome in heart-lung transplant recipients: diagnosis with expiratory CT. Radiology 218:533–539

    CAS  PubMed  Google Scholar 

  • Bano S, Chaudhary V, Narula MK et al (2014) Pulmonary Langerhans cell histiocytosis in children: a spectrum of radiologic findings. Eur J Radiol 83:47–56

    PubMed  Google Scholar 

  • Barbato A, Frischer T, Kuehni CE et al (2009) Primary ciliary dyskinesia: a consensus statement on diagnostic and treatment approaches in children. Eur Respir J 34:1264–1276

    CAS  PubMed  Google Scholar 

  • Becciolini V, Gudinchet F, Cheseaux JJ et al (2001) Lymphocytic interstitial pneumonia in children with AIDS: high-resolution CT findings. Eur Radiol 11:1015–1020

    CAS  PubMed  Google Scholar 

  • Bhalla M, Turcios N, Aponte V et al (1991) Cystic fibrosis: scoring system with thin-section CT. Radiology 179:783–788

    CAS  PubMed  Google Scholar 

  • Bomelburg T, Roos N, von Lengerke HJ et al (1992) Invasive aspergillosis complicating induction chemotherapy of childhood leukaemia. Eur J Pediatr 151:485–487

    CAS  PubMed  Google Scholar 

  • Bonelli FS, Hartman TE, Swensen SJ et al (1998) Accuracy of high-resolution CT in diagnosing lung diseases. AJR 170:1507–1512

    CAS  PubMed  Google Scholar 

  • Braier J, Latella A, Balancini B et al (2004) Outcome in children with pulmonary Langerhans cell histiocytosis. Pediatr Blood Cancer 43:765–769

    PubMed  Google Scholar 

  • Brasfield D, Hicks G, Soong SJ et al (1980) Evaluation of scoring system of the chest radiograph in cystic fibrosis: a collaborative study. AJR 134:1195–1198

    CAS  PubMed  Google Scholar 

  • Brauner MW, Grenier P, Mompoint D et al (1989a) Pulmonary sarcoidosis: evaluation with high-resolution CT. Radiology 172:467–471

    CAS  PubMed  Google Scholar 

  • Brauner MW, Grenier P, Mouelhi MM et al (1989b) Pulmonary histiocytosis X: evaluation with high-resolution CT. Radiology 172:255–258

    CAS  PubMed  Google Scholar 

  • Brauner MW, Grenier P, Tijani K et al (1997) Pulmonary Langerhans cell histiocytosis: evolution of lesions on CT scans. Radiology 204:497–502

    CAS  PubMed  Google Scholar 

  • Brody AS, Molina PL, Klein JS et al (1999) High-resolution computed tomography of the chest in children with cystic fibrosis: support for use as an outcome surrogate. Pediatr Radiol 29:731–735

    CAS  PubMed  Google Scholar 

  • Brody AS, Klein JS, Molina PL et al (2004) High-resolution computed tomography in young patients with cystic fibrosis: distribution of abnormalities and correlation with pulmonary function test. J Pediatr 145:32–38

    PubMed  Google Scholar 

  • Brody AS, Tiddens HA, Castile RG et al (2005) Computed tomography in the evaluation of cystic fibrosis lung disease. Am J Respir Crit Care Med 172:1246–1252

    PubMed  Google Scholar 

  • Brody AS, Guillerman RP, HaY TC et al (2010) Neuroendocrine cell hyperplasia of infancy: diagnosis with high-resolution CT. Am J Roentgenol 194:238–244

    Google Scholar 

  • Canakis AM, Cutz E, Manson D (2002) Pulmonary interstitial glycogenosis: a new variant of neonatal interstitial lung disease. Am J Respir Crit Care Med 165:1557–1565

    Google Scholar 

  • Carignan S, Staples CA, Müller NL (1995) Intrathoracic lymphoproliferative disorders in the immunocompromised patient: CT findings. Radiology 197:53–58

    CAS  PubMed  Google Scholar 

  • Carré A, Szinnai G, Castanet M et al (2009) Five new TTF1/NKX2.1 mutations in brain-lung-thyroid syndrome: rescue by PAX8 synergism in one case. Hum Mol Genet 18:2266–2276

    PubMed  Google Scholar 

  • Cartier Y, Kavanagh PV, Johkoh T et al (1999) Bronchiectasis: accuracy of high-resolution CT in the differentiation of specific diseases. AJR 173:47–52

    CAS  PubMed  Google Scholar 

  • Castillo M, Vade A, Lim-Dunham JE et al (2010) Pulmonary interstitial glycogenosis in the setting of lung growth abnormality: radiographic and pathologic correlation. Pediatr Radiol 40:1562–1565

    PubMed  Google Scholar 

  • Cazzato S, di Palmo E, Ragazzo V et al (2013) Interstitial lung disease in children. Early Hum Dev 89(Suppl 3):S39–S43

    PubMed  Google Scholar 

  • Ceviz N, Kaynar H, Olgun H et al (2006) Pigeon breeder’s lung in childhood: is family screening necessary? Pediatr Pulmonol 41:279–282

    PubMed  Google Scholar 

  • Chang AB, Masel JP, Masters B (1998) Post-infectious bronchiolitis obliterans: clinical, radiological and pulmonary function sequelae. Pediatr Radiol 28:25–29

    Google Scholar 

  • Chibbar R, Shih F, Baga M et al (2004) Non specific interstitial pneumonia and usual interstitial pneumonia with mutation in surfactant protein C in familial pulmonary fibrosis. Modem Pathol 17:973–980

    CAS  Google Scholar 

  • Chung CJ, Fordham LA, Barker P et al (1999) Children with congenital pulmonary lymphangiectasia: after infancy. AJR 173:1583–1588

    CAS  PubMed  Google Scholar 

  • Clement A, Task Force ERS (2004) Task force on chronic interstitial lung disease in immunocompetent children. Eur Respir J 24:686–697

    CAS  PubMed  Google Scholar 

  • Cleveland RH, Staub Neish A, Zurakowski D et al (1998) Cystic fibrosis: a system for assessing and predicting progression. AJR 170:1067–1072

    CAS  PubMed  Google Scholar 

  • Cluzel P, Grenier P, Bernadac P et al (1991) Pulmonary alveolar microlithiasis: CT findings. J Comput Assist Tomogr 15:938–942

    CAS  PubMed  Google Scholar 

  • Colby TV (1998) Bronchiolitis pathologic considerations. Am J Clin Pathol 109:101–109

    CAS  PubMed  Google Scholar 

  • Connolly B, Manson D, Eberhard A et al (1996) CT appearance of pulmonary vasculitis in children. AJR 167:901–904

    CAS  PubMed  Google Scholar 

  • Copley SJ, Coren M, Nicholson AG et al (2000) Diagnostic accuracy of thin-section CT and chest radiography of pediatric interstitial lung disease. AJR 174:549–554

    CAS  PubMed  Google Scholar 

  • Cordier JF (2000) Organising pneumonia. Thorax 55:318–328

    CAS  PubMed Central  PubMed  Google Scholar 

  • Coulier B, Mailleux P, Mairesse M et al (1999) Pulmonary alveolar proteinosis, high-resolution CT findings and evolution in 5 patients. JBR-BTR 82:277–281

    CAS  PubMed  Google Scholar 

  • Dawson WB, Müller NL (1990) High-resolution computed tomography in pulmonary sarcoidosis. Semin Ultrasound CT MR 11:423–429

    CAS  PubMed  Google Scholar 

  • de Jong PA, Ottink MD, Robben SG et al (2004) Pulmonary disease assessment in cystic fibrosis: comparison if CT scoring systems and value of bronchial and arterial dimension measurements. Radiology 231:434–439

    PubMed  Google Scholar 

  • de Jong PA, Nakano Y, Lequin MH et al (2006) Dose reduction for CT in children with cystic fibrosis: is feasible to reduce the number of images per scan. Pediatr Radiol 36:50–53

    PubMed  Google Scholar 

  • de Mol M, de Jongste JC, van Westreenen M et al (2013) Diagnosis of invasive pulmonary aspergillosis in children with bronchoalveolar lavage galactomannan. Pediatr Pulmonol 48:789–796

    PubMed  Google Scholar 

  • Deniz O, Ors F, Tozkoparan E et al (2005) High-resolution computed tomographic features of pulmonary alveolar microlithiasis. Eur J Radiol 55:452–460

    PubMed  Google Scholar 

  • Deterding RR (2012) Infants and young children with children’s interstitial lung disease. Pediatr Allergy Immunol Pulmonol 23:25–31

    Google Scholar 

  • Deterding RR, Fan LL, Morton R et al (2001) Persistent tachypnea of infancy (PTI)—a new entity. Pediatr Pulmonol 23:72–73

    PubMed  Google Scholar 

  • Deutsch GH, Young LR (2010) Pulmonary interstitial glycogenosis: words of caution. Pediatr Radiol 40:1471–1475

    PubMed  Google Scholar 

  • Deutsch GH, Young LR, Deterding RR et al (2007) Diffuse lung disease in young children: application of a novel classification scheme. Am J Respir Crit Care Med 176:1120–1128

    PubMed Central  PubMed  Google Scholar 

  • Dinwiddie R, Sharief N, Crawford O (2002) Idiopathic interstitial pneumonitis in children: a national survey in the United Kingdomand Ireland. Pediatr Pulmonol 34:23–29

    CAS  PubMed  Google Scholar 

  • Doan ML, Guillerman RP, Dishop M et al (2008) Clinical, radiological and pathological features of ABCA3 mutations in children. Thorax 63:366–373

    CAS  PubMed  Google Scholar 

  • Dodd JD, Souza CA, Muller NL (2006) Conventional high-resolution CT versus helical high-resolution MDCT in the detection of bronchiectasis. AJR 187:414–420

    PubMed  Google Scholar 

  • Donnelly LF (2000) Langerhan’s cell histiocytosis showing low-attenuation mediastinal mass and cystic lung disease. AJR 174:877–878

    CAS  PubMed  Google Scholar 

  • Drent M, de Vries J, Lenters M et al (2003) Sarcoidosis: assessment of disease severity using HRCT. Eur Radiol 13:2462–2471

    PubMed  Google Scholar 

  • Duchateau F, Dechambre S, Coche E (2001) Imaging of pulmonary manifestations in subtype B of Niemann-Pick disease. Br J Radiol 74:1059–1061

    CAS  PubMed  Google Scholar 

  • Dutheil-Doco A, Ducou le Pointe H, Larroquet M et al (1997) Maladie de Gorham à manifestation pleuro-pulmonaire prédominante. J Radiol 78:665–667

    CAS  PubMed  Google Scholar 

  • Edwards EA, Metcalfe R, Milne DG (2003) Retrospective review of children presenting with non cystic fibrosis bronchiectasis: HRCT features and clinical relationships. Pediatr Pulmonol 36:87–93

    CAS  PubMed  Google Scholar 

  • Eichinger M, Optazaite DE, Kopp-Schneider A et al (2012) Morphologic and functional scoring of cystic fibrosis lung disease using MRI. Eur J Radiol 81:1321–1329

    PubMed  Google Scholar 

  • Fauré C, Verderi D, Schmit P et al (1986) The chest film in immotile cilia syndrome in children. Ann Radiol 29:301–311

    PubMed  Google Scholar 

  • Fauroux B, Clément A (2005) Paediatric sarcoidosis. Paediatr Respir Rev 6:128–133

    PubMed  Google Scholar 

  • Fenlon HM, Doran M, Sant SM et al (1996) High-resolution chest CT in systemic lupus erythematosus. AJR 166:301–307

    CAS  PubMed  Google Scholar 

  • Feretti GR, Lantuejoul S, Brambilla E et al (1996) Pulmonary involvement in Niemann-Pick disease subtype B: CT findings. J Comput Assist Tomogr 20:990–992

    Google Scholar 

  • Flowers JR, Clunie G, Burke M et al (1992) Bronchiolitis obliterans organizing pneumonia: the clinical and radiological features of seven cases and a review of the literature. Clin Radiol 45:371–377

    CAS  PubMed  Google Scholar 

  • Gaillard EA, Carty H, Heaf D et al (2003) Reversible bronchial dilatation in children: comparison of serial high-resolution computer tomography scans of the lungs. Eur J Radiol 47:215–220

    CAS  PubMed  Google Scholar 

  • Galambos C, Levy H, Cannon CL et al (2010) Pulmonary pathology in thyroid transcription factor-1 deficiency syndrome. Am J Respir Crit Care Med 182:549–554

    PubMed Central  PubMed  Google Scholar 

  • Godwin JD, Müller NL, Takasugi JE (1988) Pulmonary alveolar proteinosis: CT findings. Radiology 169:609–613

    CAS  PubMed  Google Scholar 

  • Goitein O, Elstein D, Abrahamov A et al (2001) Lung involvement and enzyme replacement therapy in Gaucher’s disease. QJM 94:407–415

    CAS  PubMed  Google Scholar 

  • Goo HW, Yang DH, Hong SJ et al (2010) Xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results. Pediatr Radiol 40:1490–1497

    PubMed  Google Scholar 

  • Gower WA, Nogee LM (2011) Surfactant dysfunction. Paediatr Respir Rev 12:223–229

    PubMed Central  PubMed  Google Scholar 

  • Grenier P, Maurice F, Musset D et al (1986) Bronchiectasis: assessment by thin-section CT. Radiology 161:95–99

    CAS  PubMed  Google Scholar 

  • Grenier P, Lenoir S, Brauner M (1990) Computed tomographic assessment of bronchiectasis. Semin Ultrasound CT MR 11:430–441

    CAS  PubMed  Google Scholar 

  • Grenier P, Chevret S, Beigelman C et al (1994) Chronic diffuse infiltrative lung disease: determination of the diagnostic value of clinical data, chest radiography, and CT with Bayesian analysis. Radiology 191:383–390

    CAS  PubMed  Google Scholar 

  • Grenier P, Mourey-Gerosa I, Benali K et al (1996) Abnormalities of the lung and lung parenchyma in asthmatics: CT observations in 50 patients and inter- and intraobsever variability. Eur Radiol 6:199–206

    CAS  PubMed  Google Scholar 

  • Griese M, Haug M, Brasch F et al (2009) Incidence and classification of pediatric diffuse parenchymal lung diseases in Germany. Orphanet J Rare Dis 4:26

    PubMed Central  PubMed  Google Scholar 

  • Grossman H, Merten DF, Spock A et al (1985) Radiographic features of sarcoidosis in pediatric patients. Semin Roentgenol 20:393–399

    Google Scholar 

  • Guan Y, Zeng Q, Yang H et al (2012) Pulmonary alveolar proteinosis: quantitative CT and pulmonary functional Correlations. Eur J Radiol 81:2430–2435

    Google Scholar 

  • Guillerman RP (2010) Imaging of childhood interstitial lung disease. Pediatr Allergy Immunol Pulmonol 23:43–68

    PubMed Central  PubMed  Google Scholar 

  • Guillot L, Carré A, Szinnai G et al (2012) NKX2-1 mutations leading to surfactant protein promoter dysregulation cause interstitial lung disease in “Brain-Lung-Thyroid Syndrome”. Hum Mutat 31:E1146–E1162

    Google Scholar 

  • Hansell DM (1998) Bronchiectasis. Radiol Clin North Am 36:107–128

    CAS  PubMed  Google Scholar 

  • Hansell DM, Moskovic E (1991) High-resolution computed tomography in extrinsic allergic alveolitis. Clin Radiol 43:8–12

    CAS  PubMed  Google Scholar 

  • Hartman TE, Primack SL, Swenson SJ et al (1993) Desquamative interstitial pneumonia: thin-section CT findings in 22 patients. Radiology 187:787–790

    CAS  PubMed  Google Scholar 

  • Helbich TH, Wojnarovsky C; Wunderbaldinger P et al (1997) Pulmonary alveolar microlithiasis in children: radiographic and high-resolution CT findings. AJR 168:63–65

    Google Scholar 

  • Helbich TH, Heinz-Peer G, Fleischmann D et al (1999) Evolution of CT findings in patients with cystic fibrosis. AJR 173:81–88

    CAS  PubMed  Google Scholar 

  • Herman M, Michalkova K, Kopriva F (1993) High-resolution CT in the assessment of bronchiectasis in children. Pediatr Radiol 23:376–379

    CAS  PubMed  Google Scholar 

  • Hiddema A, Engelshove HA (1999) Kartagener’s syndrome. JBR-BTR 82:112

    CAS  PubMed  Google Scholar 

  • Honda O, Johkoh T, Ichikado K et al (1999) Differential diagnosis of lymphocytic interstitial pneumonia and malignant lymphoma on high-resolution CT. AJR 173:71–74

    CAS  PubMed  Google Scholar 

  • Ichikado K, Johkoh T, Ikezoe J et al (1997) Acute interstitial pneumonia: high-resolution CT findings correlated with pathology. AJR 168:333–338

    CAS  PubMed  Google Scholar 

  • Inoue T, Toyoichiro K, Kikui M (1996) Idiopathic bronchiolitis obliterans organizing pneumonia (idiopathic BOOP) in childhood. Pediatr Pulmonol 22:67–72

    CAS  PubMed  Google Scholar 

  • Jain N, Covar RA, Gleason MC et al (2005) Quantitative computed tomography detects peripheral airway disease in asthmatic children. Pediatr Pulmonol 40:211–218

    PubMed  Google Scholar 

  • Jimenez S, Jimenez JR, Crespo M et al (2006) Computed tomography in children with cystic fibrosis: a new way to reduce radiation dose. Arch Dis Child 91:388–390

    CAS  PubMed Central  PubMed  Google Scholar 

  • Johkoh T, Ikezoe J, Tomiyama N et al (1992) CT findings in lymphangitic carcinomatosis of the lung: correlation with histologic findings and pulmonary function tests. AJR 158:1217–1222

    CAS  PubMed  Google Scholar 

  • Johkoh T, Müller NL, Cartier Y et al (1999a) Idiopathic interstitial pneumonias: diagnostic accuracy of thin-section CT in 129 patients. Radiology 211:555–560

    CAS  PubMed  Google Scholar 

  • Johkoh T, Müller NL, Pickford HA et al (1999b) Lymphocytic interstitial pneumonia: thin-section CT findings in 22 patients. Radiology 212:567–572

    CAS  PubMed  Google Scholar 

  • Johkoh T, Müller NL, Taniguchi H et al (1999c) Acute interstitial pneumonia: thin section CT findings in 36 patients. Radiology 211:859–863

    CAS  PubMed  Google Scholar 

  • Katzeinstein AL, Fiorelli RF (1994) Nonspecific interstitial pneumonia/fibrosis. Histologic features and clinical significance. Am J Surg Pathol 18:136–147

    Google Scholar 

  • Katzenstein AL, Myers JL, Mazur MT (1986) Acute interstitial pneumonia. A clinicopathologic, ultrastructural, and cell kinetic study. Am J Surg Pathol 10:256–267

    CAS  PubMed  Google Scholar 

  • Kim MJ, Lee KY (1996) Bronchiolitis obliterans in children with Stevens-Johnson syndrome: follow-up with high-resolution CT. Pediatr Radiol 26:22–25

    CAS  PubMed  Google Scholar 

  • Kim JS, Müller NL, Park CS et al (1997) Cylindrical bronchiectasis: diagnostic findings on thin-section CT. AJR 168:751–754

    CAS  PubMed  Google Scholar 

  • Kiper N, Gocmen A, Ozcelik U et al (1999) Long-term clinical course of patients with idiopathic pulmonary hemosiderosis (1979–1994): prolonged survival with low-dose corticosteroid therapy. Pediatr Pulmonol 27:180–184

    CAS  PubMed  Google Scholar 

  • Kleinau I, Perez-Canto A, Schmid HJ et al (1997) Bronchiolitis obliterans organizing pneumonia and chronic graft-versus-host disease in a child after allogeneic bone marrow transplantation. Bone Marrow Transplant 19:841–844

    CAS  PubMed  Google Scholar 

  • Koh DM, Hansell DM (2000) Computed tomography of diffuse interstitial lung disease in children. Clin Radiol 55:659–667

    CAS  PubMed  Google Scholar 

  • Konez O, Vyas PK, Goyal M (2000) Disseminated lymphangiomatosis presenting with massive chylothorax. Pediatr Radiol 30:35–37

    CAS  PubMed  Google Scholar 

  • Krude H, Schütz B, Biebermann H et al (2002) Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsuffi ciency. J Clin Invest 109:475–480

    CAS  PubMed Central  PubMed  Google Scholar 

  • Kuhn JP (1993) High-resolution computed tomography of pediatric pulmonary parenchymal disorders. Radiol Clin North Am 31:533–551

    CAS  PubMed  Google Scholar 

  • Lau DM, Siegel MJ, Hildebolt CF et al (1998) Bronchiolitis obliterans syndrome: thin-section CT diagnosis of obstructive changes in infants and young children after lung transplantation. Radiology 208:783–788

    CAS  PubMed  Google Scholar 

  • Lee EY (2013) Interstitial lung disease in infants: new classification system, imaging technique, clinical presentation and imaging findings. Pediatr Radiol 43:3–13

    PubMed  Google Scholar 

  • Lee KS, Kullnig P, Hartman TE et al (1994a) Cryptogenic organizing pneumonia: CT findings in 43 patients. AJR 162:543–546

    CAS  PubMed  Google Scholar 

  • Lee KS, Primack SL, Staples CA et al (1994b) Chronic infiltrative lung disease: comparison of diagnostic accuracies of radiography and low- and conventional-dose thin-section CT. Radiology 191:669–673

    CAS  PubMed  Google Scholar 

  • Li YW, Snow J, Smith W et al (1985) Localized pulmonary lymphangiectasia. AJR 145:269–270

    CAS  PubMed  Google Scholar 

  • Liebow AA, Carrington CB (1973) Diffuse pulmonary lymphoreticular infiltrations associated with dysproteinemia. Med Clin North Am 57:809–843

    CAS  PubMed  Google Scholar 

  • Lilleby V, Aaløkken TM, Johansen B (2006) Pulmonary involvement in patients with childhood-onset systemic lupus erythematosus. Clin Exp Rheumatol 24:203–208

    CAS  PubMed  Google Scholar 

  • Logan PM, Primack SL, Miller RR et al (1994) Invasive aspergillosis of the airways: radiographic, CT and pathologic findings. Radiology 193:383–388

    CAS  PubMed  Google Scholar 

  • Lucaya J, Gartner S, Garcia-Pena P et al (1998) Spectrum of manifestations of Swyer-James-MacLeod syndrome. J Comput Assist Tomogr 22:592–597

    CAS  PubMed  Google Scholar 

  • Lucaya J, Garcio-Pena P, Herrera L et al (2000) Expiratory chest CT in children. AJR 174:235–241

    CAS  PubMed  Google Scholar 

  • Lynch DA (1998) Imaging of asthma and allergic bronchopulmonary mycosis. Radiol Clin North Am 36:129–142

    CAS  PubMed  Google Scholar 

  • Lynch DA, Hay T, Newell JD Jr et al (1999) Pediatric diffuse lung disease: diagnosis and classification using high-resolution CT. AJR 173:713–718

    CAS  PubMed  Google Scholar 

  • Marchac V, Emond S, Mamou-Mani T et al (2002) Thoracic CT in pediatric patients with difficult-to-treat asthma. AJR 179:1245–1252

    PubMed  Google Scholar 

  • Marchiori E, Zanetti G, Escuissato DL et al (2012) Reversed halo sign: high-resolution CT scan findings in 79 patients. Chest 141:1260–1266

    PubMed  Google Scholar 

  • Marti-Bonmati L, Ruiz Perales F, Catala F et al (1989) CT findings in Swyer-James syndrome. Radiology 172:477–480

    CAS  PubMed  Google Scholar 

  • Mathew P, Bozeman P, Krance RA et al (1994) Bronchiolitis obliterans organizing pneumonia (BOOP) in children after allogeneic bone marrow transplantation. Bone Marrow Transplant 13:221–223

    CAS  PubMed  Google Scholar 

  • McCook TA, Kirks DR, Merten DF et al (1981) Pulmonary alveolar proteinosis in children. AJR 137:1023–1027

    CAS  PubMed  Google Scholar 

  • McGuinness G, Naidich DP (1995) Bronchiectasis: CT/clinical correlations. Semin Ultrasound CT MR 16:395–419

    CAS  PubMed  Google Scholar 

  • Mclean AN, Sproule MW, Cowan MD et al (1998) High-resolution computed tomography in asthma. Thorax 53:308–314

    CAS  PubMed Central  PubMed  Google Scholar 

  • Mechri M, Epaud R, Emond S et al (2010) Surfactant protein C gene (SFTPC) mutation-associated lung disease: high-resolution computed tomography (HRCT) findings and its relation to histological analysis. Pediatr Pulmonol 45:1021–1029

    CAS  PubMed  Google Scholar 

  • Meeks M, Bush A (2000) Primary ciliary dyskinesia (PCD). Pediatr Pulmonol 29:307–316

    CAS  PubMed  Google Scholar 

  • Mitchell CS, Parisi MT, Osborn RE (1993) Gorham’s disease involving the thoracic skeleton. Pediatr Radiol 23:543–544

    CAS  PubMed  Google Scholar 

  • Mitchell TA, Hamilos DL, Lynch DA et al (2000) Distribution and severity of bronchiectasis in allergic bronchopulmonary aspergillosis (ABPA). J Asthma 37:65–72

    CAS  PubMed  Google Scholar 

  • Moore AD, Godwin JD, Müller NL et al (1989) Pulmonary histiocytosis X: comparison of radiographic and CT findings. Radiology 172:249–254

    CAS  PubMed  Google Scholar 

  • Moore AD, Godwin JD, Dietrich PA (1992) Swyer-James syndrome: CT findings in eight patients. AJR 158:1211–1215

    CAS  PubMed  Google Scholar 

  • Müller NL, Colby TV (1997) Idiopathic interstitial pneumonias: high-resolution CT and histologic findings. RadioGraphics 17:1016–1022

    PubMed  Google Scholar 

  • Müller NL, Staples CA, Miller RR (1990) Bronchiolitis obliterans organizing pneumonia: CT features in 14 patients. AJR 154:983–987

    PubMed  Google Scholar 

  • Munk PL, Müller NL, Miller RR et al (1988) Pulmonary lymphangitic carcinomatosis: CT and pathologic findings. Radiology 166:705–709

    CAS  PubMed  Google Scholar 

  • Murch CR, Carr DH (1989) Computed tomography appearances of pulmonary alveolar proteinosis. Clin Radiol 40:240–243

    CAS  PubMed  Google Scholar 

  • Nadel HR, Stringer DA, Levison H et al (1985) The immotile cilia syndrome: radiological manifestations. Radiology 154:651–655

    CAS  PubMed  Google Scholar 

  • Nathanson I, Conboy K, Murphy S et al (1991) Ultrafast computerized tomography of the chest in cystic fibrosis: a new scoring system. Pediatr Pulmonol 11:81–86

    CAS  PubMed  Google Scholar 

  • Newman B, Kuhn JP, Kramer SS et al (2001) Congenital surfactant protein B deficiency—emphasis on imaging. Pediatr Radiol 31:327–331

    CAS  PubMed  Google Scholar 

  • Nishimura K, Kitaichi M, Izumi T et al (1992) Usual interstitial pneumonia: histologic correlation with high-resolution CT. Radiology 182:337–342

    CAS  PubMed  Google Scholar 

  • Nishimura K, Itoh H, Kitaichi M et al (1995) CT and pathological correlation of pulmonary sarcoidosis. Semin Ultrasound CT MR 16:361–370

    CAS  PubMed  Google Scholar 

  • Nogee LM, Dunbar AE, Wert SE et al (2001) A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N Engl J Med 344:573–579

    CAS  PubMed  Google Scholar 

  • Noonan JA, Walters LR, Reeves JT (1970) Pulmonary lymphangiectasis. Am R Dis Child 120:314–319

    CAS  Google Scholar 

  • Nowers K, Rasband JD, Berges G et al (2002) Semin Ultrasound CT MR 23:302–323

    PubMed  Google Scholar 

  • O’Connor OJ, Valeur M, McGarrigle AM et al (2010) Development of low-dose protocols for thin-section CT assessment of cystic fibrosis in pediatric patients. Radiology 257:820–829

    PubMed  Google Scholar 

  • Odame I, Li P, Lau L et al (2006) Pulmonary Langerhans cell histiocytosis: a variable disease in childhood. Pediatr Blood Cancer 47:889–893

    PubMed  Google Scholar 

  • Oppenheim C, Mamou-Mani T, Sayegh N et al (1994) Bronchopulmonary dysplasia: value of CT in identifying pulmonary sequelae. AJR 163:169–172

    CAS  PubMed  Google Scholar 

  • Osika E, Muller MH, Boccon-Gibod L (1997) Idiopathic pulmonary fibrosis in infants. Pediatr Pulmonol 23:49–54

    CAS  PubMed  Google Scholar 

  • Paganin F, Trussard V, Seneterre E et al (1992) Chest radiography and high-resolution computed tomography of the lungs in asthma. Am Rev Respir Dis 146:1084–1087

    CAS  PubMed  Google Scholar 

  • Pattishall EN, Kendig EL (1996) Sarcoidosis in children. Pediatr Pulmonol 22:195–203

    CAS  PubMed  Google Scholar 

  • Primack SL, Hartman TE, Ikezoe J et al (1993) Acute interstitial pneumonia: radiographic and CT findings in nine patients. Radiology 188:817–820

    CAS  PubMed  Google Scholar 

  • Primack SL, Miller RR, Müller NL (1995) Diffuse pulmonary hemorrhage: clinical, pathologic, and imaging features. AJR 164:295–300

    CAS  PubMed  Google Scholar 

  • Ramirez RE, Glasier C, Kirks D et al (1984) Pulmonary hemorrhage associated with systemic lupus erythematosus in children. Radiology 152:409–412

    CAS  PubMed  Google Scholar 

  • Rettwitz-Volk W, Schlober R, Ahrens P et al (1999) Congenital unilobar pulmonary lymphangiectasis. Pediatr Pulmonol 27:290–292

    CAS  PubMed  Google Scholar 

  • Reyes de la Rocha S, Pysher TJ, Leonard JC (1987) Dyskinetic cilia syndrome: clinical, radiographic and scintigraphic findings. Pediatr Radiol 17:97–103

    CAS  PubMed  Google Scholar 

  • Roberton BJ, Hansell DM (2011) Organizing pneumonia: a kaleidoscope of concepts and morphologies. Eur Radiol 21:2244–2254

    PubMed  Google Scholar 

  • Rossi UG, Owens CM (2005) The radiology of chronic lung disease in children. Arch Dis Child 90:601–607

    CAS  PubMed Central  PubMed  Google Scholar 

  • Rossi SE, Erasmus JJ, Volpacchio M et al (2003) RadioGraphics 23:1509–1519

    PubMed  Google Scholar 

  • Ruzal-Shapiro C (1998) Cystic fibrosis. An overview. Radiol Clin North Am 36:143–161

    CAS  PubMed  Google Scholar 

  • Sargent MA, Cairns RA, Murdoch MJ et al (1995) Obstructive lung disease in children after allogeneic bone marrow transplantation: evaluation with high-resolution CT. AJR 164:693–696

    CAS  PubMed  Google Scholar 

  • Schumacher RE, Marrogi AJ, Heidelberger KP (1989) Pulmonary alveolar proteinosis in a newborn. Pediatr Pulmonol 7:178–182

    CAS  PubMed  Google Scholar 

  • Seely JM, Effmann EL, Müller NL (1997) High-resolution CT of pediatric lung disease: imaging findings. AJR 168:1269–1275

    CAS  PubMed  Google Scholar 

  • Seely JM, Jones LT, Wallace C (1998) Systemic sclerosis: using high-resolution CT to detect lung disease in children. AJR 170:691–697

    CAS  PubMed  Google Scholar 

  • Seely JM, Salahudeen S Sr, Cadaval-Goncalves AT et al (2012) PulmonaryLangerhans cell histiocytosis: a comparative study of computed tomography in children and adults. J Thorac Imaging 27:65–67

    PubMed  Google Scholar 

  • Shah A, Pant CS, Bhagat R et al (1992) CT in childhood allergic bronchopulmonary aspergillosis. Pediatr Radiol 22:227–228

    CAS  PubMed  Google Scholar 

  • Shah RM, Sexauer W, Ostrum BJ et al (1997) High-resolution CT in the acute exacerbation of cystic fibrosis: evaluation of acute findings, reversibility of those findings, and clinical correlation. AJR 168:375–380

    Google Scholar 

  • Sharma V, Shaaban AM, Berges G et al (2002) The radiological spectrum of small-airway diseases. Semin Ultrasound CT MR 23:339–351

    PubMed  Google Scholar 

  • Shin SM, Kim SW, Cheon JE et al (2013) Bronchopulmonary dysplasia: new high resolution computed tomography scoring system and correlation between the high resolution computed tomography score and clinical severity. Korean J Radiol 14:350–360

    PubMed Central  PubMed  Google Scholar 

  • Siegel MJ (1999) Pediatric body CT. Lippincott Williams and Wilkens, Philadelphia, p. 126

    Google Scholar 

  • Sileo C, Epaud R, Mahloul M et al (2013) Sarcoidosis in children: HRCT findings and correlation with pulmonary function tests. Pediatr Pulmonol. doi: 10.1002/ppul.22956

  • Silva CI, Colby T, Muller NL (2004) Asthma and associated conditions: high resolution CT and pathologic findings. AJR 183:817–824

    PubMed  Google Scholar 

  • Sivit CJ, Miller CR, Rakusan TA et al (1995) Spectrum of chest radiographic abnormalities in children with AIDS and pneumocystis carinii pneumonia. Pediatr Radiol 25:389–392

    CAS  PubMed  Google Scholar 

  • Small JH, Flower CD, Traill ZC et al (1996) Air-trapping in extrinsic allergic alveolitis on computed tomography. Clin Radiol 51:684–688

    CAS  PubMed  Google Scholar 

  • Smets A, Mortelé K, de Praeter G et al (1997) Pulmonary and mediastinal lesions in children with Langerhans cell histiocytosis. Pediatr Radiol 27:873–876

    CAS  PubMed  Google Scholar 

  • Sminiotopoulos JG, Lonergan GJ, Abbott RM et al (1999) Image interpretation session: 1998. RadioGraphics 19:205–233

    Google Scholar 

  • Sockrider MM, Swank PR, Seilheimer DK et al (1994) Measuring clinical status in cystic fibrosis: internal validity and reliability of the modified NIH score. Pediatr Pulmonol 17:86–96

    CAS  PubMed  Google Scholar 

  • Stauffer Ettlin M, Pache JC, Renevey F et al (2006) Bird breeder’s disease: a rare diagnosis in young children. Eur J Pediatr 165:55–61

    PubMed  Google Scholar 

  • Sterclova M, Vasakova M, Dutka J et al (2006) Extrinsic allergic alveolitis: comparative study of the bronchoalveolar lavage profiles and radiological presentation. Postgrad Med J 82:598–601

    CAS  PubMed Central  PubMed  Google Scholar 

  • Stern EJ, Samples TL (1992) Dynamic ultrafast high-resolution CT findings in a case of Swyer-James syndrome. Pediatr Radiol 22:350–352

    CAS  PubMed  Google Scholar 

  • Swensen SJ, Hartman TE, Mayo JR et al (1995) Diffuse pulmonary lymphangiectasis: CT findings. J Comput Assist Tomogr 19:348–352

    CAS  PubMed  Google Scholar 

  • Swensen SJ, Aughenbaugh GL, Myers JL (1997) Diffuse lung disease: diagnostic accuracy of CT in patients undergoing surgical biopsy of the lung. Radiology 205:229–234

    CAS  PubMed  Google Scholar 

  • Taccone A, Occhi M, Garaventa A et al (1993) CT of invasive pulmonary aspergillosis in children with cancer. Pediatr Radiol 23:177–180

    CAS  PubMed  Google Scholar 

  • Tateishi T, Ohtani Y, Takemura T et al (2011) Serial high-resolution computed tomography findings of acute and chronic hypersensitivity pneumonitis induced by avian antigen. J Comput Assist Tomogr 35:272–279

    PubMed  Google Scholar 

  • Thomas AQ, Lane K, Philipps J et al (2002) Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred. Am J Respir Crit Care Med 165:1322–1328

    PubMed  Google Scholar 

  • Thompson BH, Stanford W, Galvin JR et al (1995) Varied radiologic appearances of pulmonary aspergillosis. RadioGraphics 15:1273–1284

    CAS  PubMed  Google Scholar 

  • Traill ZC, Maskell GF, Gleeson FV (1997) High-resolution CT findings of pulmonary sarcoidosis. AJR 168:1557–1560

    CAS  PubMed  Google Scholar 

  • Tunaci A, Berkmen YM, Gokmen E (1995) Pulmonary Gaucher’s disease: high-resolution computed tomographic features. Pediatr Radiol 25:237–238

    CAS  PubMed  Google Scholar 

  • Ujita M, Renzoni EA, Veeraraghavan S et al (2004) Organizing pneumonia: perilobular pattern at thin-section CT. Radiology 232:757–761

    PubMed  Google Scholar 

  • Verlaat CW, Peters HM, Semmekrot BA et al (1994) Congenital pulmonary lymphangiectasis presenting as a unilateral hyperlucent lung. Eur J Pediatr 153:202–205

    CAS  PubMed  Google Scholar 

  • Vincent JM, Armstrong P, Wilson AG (1992) Extrinsic allergic alveolitis and eosinophilic pneumonia. Imaging 4:5–13

    Google Scholar 

  • von Vigier RO, Trummler SA, Laux-End R et al (2000) Pulmonary renal syndrome in childhood: a report of twenty-one cases and a review of the literature. Pediatr Pulmonol 29:382–388

    Google Scholar 

  • Wallis C, Whitehead B, Malone M et al (1996) Pulmonary alveolar microlithiasis in childhood: diagnosis by transbronchial biopsy. Pediatr Pulmonol 21:62–64

    CAS  PubMed  Google Scholar 

  • Ward S, Heyneman L, Lee MJ et al (1999) Accuracy of CT in the diagnosis of allergic bronchopulmonary aspergillosis in asthmatic patients. AJR 173:937–942

    CAS  PubMed  Google Scholar 

  • Webb WR (1994) High-resolution computed tomography of obstructive lung disease. Radiol Clin North Am 32:745–757

    CAS  PubMed  Google Scholar 

  • Webb WR, Müller NL, Naidich DP (1996) High-resolution CT of the lung, 2nd edn. Lippincott-Raven, Philadelphia

    Google Scholar 

  • Wittram C, Mark EJ, McLoud TG (2003) CT-Histologic correlation of the ATS/ERS 2002 classification of idiopathic interstitial pneumonias. RadioGraphics 23:1057–1071

    PubMed  Google Scholar 

  • Won HJ, Lee KS, Cheon JE et al (1998) Invasive pulmonary aspergillosis: prediction at thin-section CT in patients with neutropenia—a prospective study. Radiology 208:777–782

    CAS  PubMed  Google Scholar 

  • Yang DH, Goo HW (2006) Generalized lymphangiomatosis: radiologic findings in three pediatric patients. Korean J Radiol 7:287–291

    PubMed Central  PubMed  Google Scholar 

  • Yassa NA, Wilcox AG (1998) High-resolution CT pulmonary findings in adults with Gaucher’s disease. Clin Imaging 22:339–342

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hubert Ducou Le Pointe .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Ducou Le Pointe, H. (2014). High-Resolution CT of the Lung in Children: Clinical Applications. In: Garcia-Peña, P., Guillerman, R. (eds) Pediatric Chest Imaging. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2014_1000

Download citation

  • DOI: https://doi.org/10.1007/174_2014_1000

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37336-7

  • Online ISBN: 978-3-642-37337-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics