Abstract
Radioimmunotherapy (RIT) efficacy has been demonstrated in hematology, in particular in B cell non-Hodgkin lymphoma (NHL). RIT can be applied in clinical practice using non-ablative activity of murine anti-CD20 131I-tositumomab and 90Y-ibritumomab tiuxetan. Today, different approaches are explored to improve efficacy of RIT in NHL: myeloablative RIT, RIT as consolidation after chemotherapy, RIT in first-line treatment, fractionated RIT, RIT using other antigen targets or other monoclonal antibody. This chapter reviews current advances in the fractionated radioimmunotherapy, in particular the use of Epratuzumab Tetraxetan, a 90-Y-labeled anti-CD22 antibody in the treatment of non-Hodgkin lymphoma. We present especially the result of a phase I/II, multi center, dose-escalation trial assessing 90Y-hLL2 administered once weekly for 2 or 3 weeks, achieving high rates of durable complete responses with manageable hematological toxicity in NHL relapsing patients.
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Kraeber-Bodéré, F. et al. (2012). Fractionated Radioimmunotherapy of Non-Hodgkin Lymphoma with 90-Y-Labeled Anti-CD22 Antibody, Epratuzumab Tetraxetan. In: Baum, R. (eds) Therapeutic Nuclear Medicine. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_709
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DOI: https://doi.org/10.1007/174_2012_709
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