Abstract
FDG PET/CT is a valuable tool to evaluate many dermatologic malignancies, especially in more advanced disease states. The literature supporting the use of FDG PET/CT in staging, restaging, or treatment assessment is greatest in melanoma. When compared to conventional imaging, FDG PET/CT is superior due to better lesion sensitivity and the extended imaging coverage. Changes in management due to PET/CT results are frequently reported in more than 30% of patients with skin cancers.
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References
Abeloff MD et al (eds) (2008) Abeloff’s clinical oncology. 4th edn. Churchill Livingstone Elsevier, Philadelphia, p 2592
Akcali C et al (2007) Detection of metastases in patients with cutaneous melanoma using FDG-PET/CT. J Int Med Res 35(4):547–553
Aukema T et al (2010) Utility of preoperative 18F-FDG PET/CT and brain MRI in melanoma patients with palpable lymph node metastases. Ann Surg Oncol 17(10):2773–2778
Balch CM et al (1983) A multifactorial analysis of melanoma. IV. Prognostic factors in 200 melanoma patients with distant metastases (stage III). J Clin Oncol Off J Amer Soc Clin Oncol 1(2):126–134
Balch CM et al (2001) Prognostic factors analysis of 17, 600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging. J Clin Oncol 19(16):3622–3634
Blumer SL et al (2009) Cutaneous and subcutaneous imaging on FDG-PET: benign and malignant findings. Clin Nucl Med 34(10):675–683
Bosserhoff A (ed) (2011) Melanoma development: molecular biology. Springer-Verlag, New York, p 390
Cho SB et al (2005) Fluorodeoxyglucose positron emission tomography in cutaneous squamous cell carcinoma: retrospective analysis of 12 patients. Dermatol Surg 31(4):442–446 (Discussion 446-7)
Concannon R, Larcos GS, Veness M (2010) The impact of 18F-FDG PET-CT scanning for staging and management of Merkel cell carcinoma: results from Westmead Hospital, Sydney, Australia. J Am Acad Dermatol 62(1):76–84
Da Forno PD, Saldanha GS (2011) Molecular aspects of melanoma. Clin Lab Med 31(2):331–343
Denoyer D et al (2010) High-contrast PET of melanoma using (18)F-MEL050, a selective probe for melanin with predominantly renal clearance. J Nucl Med 51(3):441–447
Denoyer D et al (2011) Improved detection of regional melanoma metastasis using 18F–6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide, a melanin-specific PET probe, by perilesional administration. J Nucl Med 52(1):115–122
Dimitrakopoulou-Strauss A, Strauss LG, Burger C (2001) Quantitative PET studies in pretreated melanoma patients: a comparison of 6-[18F]fluoro-L-dopa with 18F-FDG and (15)O-water using compartment and noncompartment analysis. J Nucl Med 42(2):248–256
Dirisamer A et al (2008) Dual-time-point FDG-PET/CT for the detection of hepatic metastases. Mol Imag Biology 10(6):335–340
Edge S et al (eds) (2009) AJCC cancer staging manual, 7th edn. Springer, New York
Elstrom R et al (2003) FDG-PET scanning in lymphoma by WHO classification. Blood 101(10):3875–3876
Essler M et al (2011) Prognostic value of [18F]-fluoro-deoxy-glucose PET/CT, S100 or MIA for assessment of cancer-associated mortality in patients with high risk melanoma. PLoS ONE 6(9):e24632
Etchebehere EC et al (2010) Impact of [F-18] FDG-PET/CT in the restaging and management of patients with malignant melanoma. Nucl Med Commun 31(11):925–930
Feeney J et al (2010) Characterization of T-cell lymphomas on FDG PET/CT. Am J Roentgenol 195(2):333–340
Fosko SW et al (2003) Positron emission tomography for basal cell carcinoma of the head and neck. Arch Dermatol 139(9):1141–1146
Freton A et al (2011) Initial PET/CT staging for choroidal melanoma: AJCC correlation and second nonocular primaries in 333 patients. Eur J Ophthalmol 22(2):236–243
Friedman KP, Wahl RL (2004) Clinical use of positron emission tomography in the management of cutaneous melanoma. Semin Nucl Med 34(4):242–253
Gritters L et al (1993) Initial assessment of positron emission using 2-fluorine-18-fluoro-2-deoxy-d-glucose in the imaging of malignant melanoma. J Nucl Med 34:1420–1427
Gulec SA et al (2003) The role of fluorine-18 deoxyglucose positron emission tomography in the management of patients with metastatic melanoma: impact on surgical decision making. Clin Nucl Med 28(12):961–965
Habif TP (2010) Clinical dermatology. 5th edn. Elsevier, Mosby
Haerle SK et al (2011) The value of (18)F-FDG-PET/CT imaging for sinonasal malignant melanoma. Eur Arch Otorhinolaryngol 269(1):127–33
Hamid O et al (2011) Systemic treatments of metastatic melanoma: new approaches. J Surg Onc 104:425–429
Hocker T, Tsao H (2007) Ultraviolet radiation and melanoma: a systematic review and analysis or reported sequence variants. Hum Mutat 28(6):578–588
Hodi F et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:711–723
Hofman MS et al (2007) Assessing response to chemotherapy in metastatic melanoma with FDG PET: early experience. Nucl Med Commun 28(12):902–906
Iagaru A et al (2006) Merkel cell carcinoma: Is there a role for 2-deoxy-2-[f-18]fluoro-d-glucose-positron emission tomography/computed tomography? Mol Imag Biology : MIB : Off Publ Acad Mol Imag 8(4):212–217
Jimenez-Requena F et al (2010) Meta-analysis of the performance of 18F-FDG PET in cutaneous melanoma. Eur J Nucl Med Mol Imag 37:284–300
Kako S et al (2007) FDG-PET in T-cell and NK-cell neoplasms. Ann Oncol 18:1685–1690
Kalady MF et al (2003) Thin melanomas: predictive lethal characteristics from a 30-year clinical experience. Ann Surg 238(4):528–535 Discussion 535–7
Kalkanis D et al (2011) F-18 FDG PET positive hilar and mediastinal lymphadenopathy mimicking metastatic disease in a melanoma patient treated with interferon-alpha-2b. Clin Nucl Med 36(2):154–155
Kern K (1991) [14C]deoxyglucose uptake and imaging in malignant melanoma. J Surg Res 50:643–647
Kim J-S et al (2010) Before and after treatment 18F-FDG PET/CT images in a patient with cutaneous T-cell lymphoma. Eur J Nucl Med Mol Imag 37:1995
Krug B et al (2008) Role of PET in the initial staging of cutaneous malignant melanoma: systematic review. Radiology 249(3):836–844
Kumar R et al (2006) 18F-fluorodeoxyglucose-positron emission tomography in evaluation of primary cutaneous lymphoma. Br J Dermatol 155:357–363
Kuo PH et al (2008a) FDG-PET/CT in the evaluation of cutaneous T-cell lymphoma. Mol Imag Biol 10:74–81
Kuo PH et al (2008b) FDG-PET/CT for the evaluation of response to therapy of cutaneous T-cell lymphoma to vorinostat (suberoylanilide hydroxamic acid, SAHA) in a phase II trial. Mol Imag Biol 10:306–314
Kurli M, Chin K, Finger PT (2008) Whole-body 18 FDG PET/CT imaging for lymph node and metastatic staging of conjunctival melanoma. Br J Ophthalmol 92(4):479–482
Lachiewicz AM et al (2008) Epidemiologic support for melanoma heterogeneity using the surveillance, epidemiology, and end results program. J Invest Dermatol 128(5):1340–1342
Lamarre ED et al (2011) Role of positron emission tomography in management of sinonasal neoplasms-a single institution’s experience. Amer J Otolaryngol. PMID 21925763 [Epub ahead of print]
Lampreave JL et al (1998) PET evaluation of therapeutic limb perfusion in Merkel’s cell carcinoma. J Nucl Med 39(12):2087–2090
Laver NV, McLaughlin ME, Duker JS (2010) Ocular melanoma. Arch Pathol Lab Med 134(12):1778–1784
Leong SP et al (2011) Cutaneous melanoma: a model to study cancer metastasis. J Surg Onc 103:538–549
Lindholm P et al (1995) Carbon-11-methionine PET imaging of malignant melanoma. J Nucl Med 36(10):1806–1810
Maury F et al (2011) Interest of (18)F-FDG PET-CT scanning for staging and management of merkel cell carcinoma: a retrospective study of 15 patients. J Eur Acad Dermatol Venereol doi: 10.1111/j.1468-3083.2011.03994.x
Mercier GA, Alavi A, Fraker DL (2001) FDG positron emission tomography in isolated limb perfusion therapy in patients with locally advanced melanoma: preliminary results. Clin Nucl Med 26(10):832–836
Metser U, Even-Sapir E (2007) Increased (18)F-fluorodeoxyglucose uptake in benign, nonphysiologic lesions found on whole-body positron emission tomography/computed tomography (PET/CT): accumulated data from four years of experience with PET/CT. Semin Nucl Med 37(3):206–222
Metser U et al (2007) Benign nonphysiologic lesions with increased 18F-FDG uptake on PET/CT: characterization and incidence. Am J Roentgenol 189(5):1203–1210
Mishima Y et al (1997) In vivo diagnosis of human malignant melanoma with positron emission tomography using specific melanoma-seeking 18F-DOPA analogue. J Neurooncol 33(1–2):163–169
Nieder C, Grosu AL (2005) Response monitoring by positron emission tomography during radiotherapy of a squamous cell skin carcinoma. Onkologie 28(10):505–507
Niederkohr RD et al (2007) Clinical value of including the head and lower extremities in 18F-FDG PET/CT imaging for patients with malignant melanoma. Nucl Med Commun 28(9):688–695
Peloschek P et al (2010) Diagnostic imaging in Merkel cell carcinoma: lessons to learn from 16 cases with correlation of sonography, CT, MRI and PET. Eur J Radiol 73(2):317–323
Pfannenberg C et al (2007) Prospective comparison of 18F-fluorodeoxyglucose positron emission tomography/computed tomography and whole-body magnetic resonance imaging in staging of advanced malignant melanoma. Eur J Cancer 43(3):557–564
Pfluger T et al (2011) PET/CT in malignant melanoma: contrast-enhanced CT versus plain low-dose CT. Eur J Nucl Med Mol Imag 38(5):822–831
Plettenberg A et al (1995) Human melanocytes and melanoma cells constitutively express the Bcl-2 proto-oncogene in situ and in cell culture. Am J Pathol 146(3):651–659
Querellou S et al (2010) Clinical and therapeutic impact of 18F-FDG PET/CT whole-body acquisition including lower limbs in patients with malignant melanoma. Nucl Med Commun 31(9):766–772
Quevado W, Szabo GJ (1969) Influence of age and UV on the populations of dopa-positive melanocytes in human skin. J Invest Dermatol 52(3):287–290
Reinhardt MJ et al (2006) Diagnostic performance of whole body dual modality 18F-FDG PET/CT imaging for N- and M-staging of malignant melanoma: experience with 250 consecutive patients. J Clin Oncol 24(7):1178–1187
Ren G, Pan Y, Cheng Z (2010) Molecular probes for malignant melanoma imaging. Curr Pharm Biotechnol 11(6):590–602
Ribas A et al (2010) Imaging of CTLA4 blockade-induced cell replication with (18)F-FLT PET in patients with advanced melanoma treated with tremelimumab. J Nucl Med 51(3):340–346
Robert C et al (2011) Ipilimumab plus dacarbazine for previously treated metastatic melanoma. N Engl J Med 364:2517–2526
Seetharamu N, Ott PA, Pavlick AC (2010) Mucosal melanomas: a case-based review of the literature. The Oncologist 15(7):772–781
Shapiro M et al (2002) Assessment of tumor burden and treatment response by 18F-fluorodeoxyglucose injection and positron emission tomography in patients with cutaneous T- and B-cell lymphomas. J Am Acad Dermatol 47(4):623–628
Society AC (2011a) Cancer Facts & Figures 2011. American Cancer Society, Atlanta
Society AC (2011b) Melanoma skin cancer. In: American Cancer Society, A.C. Society, Editor 2011, American Cancer Society, Atlanta
Spraul CW, Lang GE, Lang GK (2001) Value of positron emission tomography in the diagnosis of malignant ocular tumors. Ophthalmologica. J Int d’ophtalmologie. Int J Ophthalmol. Zeitschrift fur Augenheilkunde 215(3):163–168
Strobel K et al (2007) High risk melanoma: accuracy of FDG PET/CT with added CT morphologic information for detection of metastases. Radiology 244(2):566–574
Strobel K et al (2008) Chemotherapy response assessment in stage IV melanoma patients-comparison of 18F-FDG-PET/CT, CT, brain MRI, and tumormarker S-100B. Eur J Nucl Med Mol Imag 35(10):1786–1795
Strobel K et al (2009) Limited value of 18F-FDG PET/CT and S-100B tumour marker in the detection of liver metastases from uveal melanoma compared to liver metastases from cutaneous melanoma. Eur J Nucl Med Mol Imag 36(11):1774–1782
Talbot J-N et al (2005) 6-[F-18]Fluoro-L-DOPA positron emission tomography in the imaging of merkel cell carcinoma: preliminary report of three cases with 2-Deoxy-2-[F-18]Fluoro-d-glucose positron emission tomography or pentetreotide-(111In) SPECT data. Mol Imaging Biol 7:257–261
Tsai EY et al (2006) Staging accuracy in mycosis fungoides and Sezary syndrome using positron emission tomography and computed tomography. Arch Dermatol 142:577–584
Uren RF et al (2011) Guidelines for lymphoscintigraphy and F18 FDG PET scans in melanoma. J Surg Onc 104:405–419
Valencak J et al (2004) Positron emission tomography with [18F] 2-fluoro-D-2-deoxyglucose in primary cutaneous T-cell lymphomas. Haematologica 89(1):115–116
Valk P et al (1996) Cost-effectiveness of PET imaging in clinical oncology. Nucl Med Biol 23(6):737–743
Wagner J et al (2001) FDG-PET sensitivity for melanoma lymph node metastases is dependent on tumor volume. J Surg Onc 77(4):237–242
Wahl R et al (1991) 18F–2-deoxyglucose-2-fluoro-d-glucose uptake into human tumor xenografts. Feasibility studies for cancer imaging with positron-emission tomography. Cancer 67:1544–1550
Ware R et al (2011) First human study of N-(2-(diethylamino)ethyl)-6-[F-18]fluoropyridine-3-carboxamide (MEL050). J Nucl Med 52(Suppl 1):415
Wehrli NE et al (2007) Determination of age-related changes in structure and function of skin, adipose tissue, and skeletal muscle with computed tomography, magnetic resonance imaging, and positron emission tomography. Semin Nucl Med 37(3):195–205
Wong HH, Wang J (2010) Merkel cell carcinoma. Arch Pathol Lab Med 134(11):1711–1716
Wong CO, Pham AN, Dworkin HJ (2000) F-18 FDG accumulation in an octreotide negative Merkel cell tumor. Clin Positron Imag 3(2):71–73
Yang J (2011) Melanoma vaccines. Cancer J 17(5):277–282
Yu L et al (1999) Detection of microscopic melanoma metastases in sentinel lymph nodes. Cancer 86:617–627
Zwald FOR, Brown M (2011) Skin cancer in solid organ transplant recipients: advances in therapy and management. part I. Epidemiology of skin cancer in solid organ transplant recipients. J Am Acad Dermatol 65(2):253–261
Acknowledgments
The authors would like to thank Khalil Salman, MD, and Robert Lucaj, MD, for their help in preparing some of the cases.
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Brandon, D., Barron, B. (2012). Dermatological. In: Peller, P., Subramaniam, R., Guermazi, A. (eds) PET-CT and PET-MRI in Oncology. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_498
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DOI: https://doi.org/10.1007/174_2011_498
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