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Advances in Radiation Oncology in Lung Cancer pp 157–172Cite as

Four-dimensional Radiation Therapy for Non-Small Cell Lung Cancer: A Clinical Perspective

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The purpose of this chapter is to review 4-dimensional radiotherapy (4DRT) for lung cancer in a way that supports the wider adoption of existing technologies and effective treatment strategies. 4DRT is defined, the components of a 4DRT program are identified, resource-sensitive 4DRT strategies are addressed and our own institution's approach to 4D lung RT is discussed.

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References

  • Admiraal MA, Schuring D, Hurkmans CW (2008) Dose calculations accounting for breathing motion in stereotactic lung radiotherapy based on 4D-CT and the internal target volume. Radiother Oncol 86(1):55–60

    Article  PubMed  Google Scholar 

  • Albain KS, Crowley JJ, Turrisi AT III, Gandara DR, Farrar WB, Clark JI, Beasley KR, Livingston RB (2002) Concurrent cisplatin, etoposide, and chest radiotherapy in pathologic stage IIIB non-small-cell lung cancer: a Southwest Oncology Group phase II study, SWOG 9019. J Clin Oncol 20(16):3454–3460

    Article  PubMed  CAS  Google Scholar 

  • Aristophanous M, Berbeco RI, Killoran JH, Yap JT, Sher DJ, Allen AM, Larson E, Chen AB (2011) Clinical Utility of 4D FDG-PET/CT Scans in Radiation Treatment Planning. Int J Radiat Oncol Biol Phys [Epub ahead of print]http://dx.doi.org/10.1016/j.ijrobp.2010.12.060

  • Armstrong JG, Burman C, Leibel S, Fontenla D, Kutcher G, Zelefsky M, Fuks Z (1993) Three-dimensional conformal radiation therapy may improve the therapeutic ratio of high-dose radiation therapy for lung cancer. Int J Radiat Oncol Biol Phys 26(4):685–689

    Article  PubMed  CAS  Google Scholar 

  • Arvidson NB, Mehta MP, Tomé WA (2008) Dose coverage beyond the gross tumor volume for various stereotactic body radiotherapy planning techniques reporting similar control rates for stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 72(5):1597–1603

    Article  PubMed  Google Scholar 

  • Balter JM, Ten Haken RK, Lawrence TS, Lam KL, Robertson JM (1996) Uncertainties in CT-based radiation therapy treatment planning associated with patient breathing. Int J Radiat Oncol Biol Phys 36(1):167–174

    Article  PubMed  CAS  Google Scholar 

  • Bentzen SM (2008) Radiation oncology health technology assessment: the best is the enemy of the good. Nat Clin Pract Oncol 5(10):563

    Article  PubMed  Google Scholar 

  • Blomgren H, Lax I, Näslund I, Svanström R (1995) Stereotactic high-dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients. Acta Oncol 34(6):861–870

    Article  PubMed  CAS  Google Scholar 

  • Chang JY, Cox JD (2010) Improving radiation conformality in the treatment of non-small cell lung cancer. Semin Radiat Oncol 20(3):171–177

    Article  PubMed  Google Scholar 

  • Chen QS, Weinhous MS, Deibel FC, Ciezki JP, Macklis RM (2001) Fluoroscopic study of tumor motion due to breathing: facilitating precise radiation therapy for lung cancer patients. Med Phys 28(9):1850–1856

    Article  PubMed  CAS  Google Scholar 

  • Chinneck CD, McJury M, Hounsell AR (2010) The potential for undertaking slow CT using a modern CT scanner. Br J Radiol 83(992):687–693

    Article  PubMed  CAS  Google Scholar 

  • Cho PS, Johnson RH, Griffin TW (1995) Cone-beam CT for radiotherapy applications. Phys Med Biol 40(11):1863–1883

    Article  PubMed  CAS  Google Scholar 

  • Clarkson JR, Leech HJ, Taylor AG, Mason SW (1959) A moving-beam caesium 137 telecurie unit. Br J Radiol 32:798–804

    Article  PubMed  CAS  Google Scholar 

  • Coolens C, Breen S, Purdie TG, Owrangi A, Publicover J, Bartolac S, Jaffray DA (2009) Implementation and characterization of a 320-slice volumetric CT scanner for simulation in radiation oncology. Med Phys 36(11):5120–5127

    Article  PubMed  CAS  Google Scholar 

  • Cuijpers JP, Verbakel WF, Slotman BJ, Senan S (2010) A novel simple approach for incorporation of respiratory motion in stereotactic treatments of lung tumors. Radiother Oncol 97(3):443–448

    Article  PubMed  Google Scholar 

  • Curran WJ, Scott CB, Langer CJ (2003) Long-term benefit is observed in a phase III comparison of sequential vs concurrent chemoradiation for patients with unresected stage III NSCLC: RTOG 9410 (Abstract). Proc Am Soc Clin Oncol 22:621

    Google Scholar 

  • Dahele M, Slotman B (2011) Implementing new radiotherapy techniques. Br J Healthc Manag Guide Healthc Technol 17(3):22–30

    Google Scholar 

  • De Ruysscher D, Faivre-Finn C, Nestle U, Hurkmans CW, Le Péchoux C, Price A, Senan S (2010) European Organisation for Research and Treatment of Cancer recommendations for planning and delivery of high-dose, high-precision radiotherapy for lung cancer. J Clin Oncol 28(36):5301–5310

    Article  PubMed  Google Scholar 

  • Derycke S, Van Duyse B, De Gersem W, De Wagter C, De Neve W (1997) Non-coplanar beam intensity modulation allows large dose escalation in stage III lung cancer. Radiother Oncol 45(3):253–261

    Article  PubMed  CAS  Google Scholar 

  • Devic S, Tomic N, Faria S, Menard S, Lisbona R, Lehnert S (2010) Defining radiotherapy target volumes using 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography: still a Pandora’s box? Int J Radiat Oncol Biol Phys 78(5):1555–1562

    Article  PubMed  Google Scholar 

  • Dieleman EM, Senan S, Vincent A, Lagerwaard FJ, Slotman BJ, de Koste JR (2007) Four-dimensional computed tomographic analysis of esophageal mobility during normal respiration. Int J Radiat Oncol Biol Phys 67(3):775–780

    Article  PubMed  Google Scholar 

  • Dillman RO, Seagren SL, Propert KJ, Guerra J, Eaton WL, Perry MC, Carey RW, Frei EF III, Green MR (1990) A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. N Engl J Med 323(14):940–945

    Article  PubMed  CAS  Google Scholar 

  • Dillman RO, Herndon J, Seagren SL, Eaton WL Jr, Green MR (1996) Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of cancer and leukemia group B (CALGB) 8433 trial. J Natl Cancer Inst 88(17):1210–1215

    Article  PubMed  CAS  Google Scholar 

  • Donnelly ED, Parikh PJ, Lu W, Zhao T, Lechleiter K, Nystrom M, Hubenschmidt JP, Low DA, Bradley JD (2007) Assessment of intrafraction mediastinal and hilar lymph node movement and comparison to lung tumor motion using four-dimensional CT. Int J Radiat Oncol Biol Phys 69(2):580–588

    Article  PubMed  Google Scholar 

  • Elmpt W, Ollers M, Velders M, Poels K, Mijnheer B, Ruysscher DD, Dekker A, Lambin P, Boersma L (2008) Transition from a simple to a more advanced dose calculation algorithm for radiotherapy of non-small cell lung cancer (NSCLC): implications for clinical implementation in an individualized dose–escalation protocol. Radiother Oncol 88(3):326–334

    Article  PubMed  Google Scholar 

  • Emami B, Purdy JA, Manolis J, Barest G, Cheng E, Coia L, Doppke K, Galvin J, LoSasso T, Matthews J et al (1991) Three-dimensional treatment planning for lung cancer. Int J Radiat Oncol Biol Phys 21(1):217–227

    Article  PubMed  CAS  Google Scholar 

  • Franks KN, Purdie TG, Dawson LA, Bezjak A, Jaffray DA, Bissonnette JP (2010) Incorporating heterogeneity correction and 4DCT in lung stereotactic body radiation therapy (SBRT): The effect on target coverage, organ-at-risk doses, and dose conformity. Med Dosim 35(2):101–107

    Article  PubMed  Google Scholar 

  • Gandara DR, Chansky K, Albain KS, Leigh BR, Gaspar LE, Lara PN Jr, Burris H, Gumerlock P, Kuebler JP, Bearden JD III, Crowley J, Livingston R (2003) Southwest Oncology Group. Consolidation docetaxel after concurrent chemoradiotherapy in stage IIIB non-small-cell lung cancer: phase II Southwest Oncology Group Study S9504. J Clin Oncol 21(10):2004–2010

    Article  PubMed  CAS  Google Scholar 

  • Graham MV, Matthews JW, Harms WB Sr, Emami B, Glazer HS, Purdy JA (1994) Three-dimensional radiation treatment planning study for patients with carcinoma of the lung. Int J Radiat Oncol Biol Phys 29(5):1105–1117

    Article  PubMed  CAS  Google Scholar 

  • Guckenberger M, Wilbert J, Meyer J, Baier K, Richter A, Flentje M (2007) Is a single respiratory correlated 4D-CT study sufficient for evaluation of breathing motion? Int J Radiat Oncol Biol Phys 67(5):1352–1359

    Article  PubMed  Google Scholar 

  • Herzlinger RE (2006) Why innovation in health care is so hard. Harv Bus Rev 84(5):58–66 156

    PubMed  Google Scholar 

  • Higgins J, Bezjak A, Hope A, Panzarella T, Li W, Cho JB, Craig T, Brade A, Sun A, Bissonnette JP (2010) Effect of Image-Guidance Frequency on Geometric Accuracy and Setup Margins in Radiotherapy for Locally Advanced Lung Cancer. Int J Radiat Oncol Biol Phys [Epub ahead of print]http://dx.doi.org/10.1016/j.ijrobp.2010.04.006

  • Hurkmans CW, Cuijpers JP, Lagerwaard FJ, Widder J, van der Heide UA, Schuring D, Senan S (2009) Recommendations for implementing stereotactic radiotherapy in peripheral stage IA non-small cell lung cancer: report from the Quality Assurance Working Party of the randomised phase III ROSEL study. Radiat Oncol 4:1

    Article  PubMed  Google Scholar 

  • Hurkmans CW, van Lieshout M, Schuring D, van Heumen MJ, Cuijpers JP, Lagerwaard FJ, Widder J, van der Heide UA, Senan S (2011) Quality assurance of 4D-CT scan techniques in multicenter phase iii trial of surgery versus stereotactic radiotherapy (Radiosurgery or surgery for operable early stage (Stage 1A) non-small-cell Lung cancer [ROSEL] Study). Int J Radiat Oncol Biol Phys 80(3):918–927

    Article  PubMed  Google Scholar 

  • Inoue A, Kunitoh H, Sekine I, Sumi M, Tokuuye K, Saijo N (2001) Radiation pneumonitis in lung cancer patients: a retrospective study of risk factors and the long-term prognosis. Int J Radiat Oncol Biol Phys 49(3):649–655

    Article  PubMed  CAS  Google Scholar 

  • Jaffray DA, Siewerdsen JH, Wong JW, Martinez AA (2002) Flat-panel cone-beam computed tomography for image-guided radiation therapy. Int J Radiat Oncol Biol Phys 53(5):1337–1349

    Article  PubMed  Google Scholar 

  • Jiang SB, Wolfgang J, Mageras GS (2008) Quality assurance challenges for motion-adaptive radiation therapy: gating, breath holding, and four-dimensional computed tomography. Int J Radiat Oncol Biol Phys 71(1 suppl):S103–S107

    Article  PubMed  Google Scholar 

  • Kamada T, Tsujii H, Mizoe JE, Matsuoka Y, Tsuji H, Osaka Y, Minohara S, Miyahara N, Endo M, Kanai T (1999) A horizontal CT system dedicated to heavy-ion beam treatment. Radiother Oncol 50(2):235–237

    Article  PubMed  CAS  Google Scholar 

  • Keall P (2004) 4 dimensional computed tomography imaging and treatment planning. Semin Radiat Oncol 14(1):81–90

    Article  PubMed  Google Scholar 

  • Keall PJ, Mageras GS, Balter JM, Emery RS, Forster KM, Jiang SB, Kapatoes JM, Low DA, Murphy MJ, Murray BR, Ramsey CR, Van Herk MB, Vedam SS, Wong JW, Yorke E (2006a) The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Med Phys 33(10):3874–3900

    Article  PubMed  Google Scholar 

  • Keall P, Vedam S, George R, Bartee C, Siebers J, Lerma F, Weiss E, Chung T (2006b) The clinical implementation of respiratory-gated intensity-modulated radiotherapy. Med Dosim 31(2):152–162

    Article  PubMed  Google Scholar 

  • Kong FM, Ten Haken RK, Schipper MJ, Sullivan MA, Chen M, Lopez C, Kalemkerian GP, Hayman JA (2005) High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: long-term results of a radiation dose escalation study. Int J Radiat Oncol Biol Phys 63(2):324–333

    Article  PubMed  Google Scholar 

  • Kotter JP (1995) Leading change: why transformation efforts fail. Harv Bus Rev 73(2):59–67

    Google Scholar 

  • Lagerwaard FJ, Senan S (2007) Lung cancer: intensity-modulated radiation therapy, four-dimensional imaging and mobility management. Front Radiat Ther Oncol 40:239–252

    Article  PubMed  Google Scholar 

  • Lagerwaard FJ, van Sornsen De Koste JR, Nijssen-Visser MR, Schuchhard-Schipper RH, Oei SS, Munne A, Senan S (2001) Multiple “slow” CT scans for incorporating lung tumor mobility in radiotherapy planning. Int J Radiat Oncol Biol Phys 51(4):932–937

    Article  PubMed  CAS  Google Scholar 

  • Lagerwaard FJ, Haasbeek CJ, Smit EF, Slotman BJ, Senan S (2008) Outcomes of risk-adapted fractionated stereotactic radiotherapy for stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 70(3):685–692

    Article  PubMed  Google Scholar 

  • Liao ZX, Komaki RR, Thames HD Jr, Liu HH, Tucker SL, Mohan R, Martel MK, Wei X, Yang K, Kim ES, Blumenschein G, Hong WK, Cox JD (2010) Influence of technologic advances on outcomes in patients with unresectable, locally advanced non-small-cell lung cancer receiving concomitant chemoradiotherapy. Int J Radiat Oncol Biol Phys 76(3):775–781

    Article  PubMed  Google Scholar 

  • Liu HH, Balter P, Tutt T, Choi B, Zhang J, Wang C, Chi M, Luo D, Pan T, Hunjan S, Starkschall G, Rosen I, Prado K, Liao Z, Chang J, Komaki R, Cox JD, Mohan R, Dong L (2007) Assessing respiration-induced tumor motion and internal target volume using four-dimensional computed tomography for radiotherapy of lung cancer. Int J Radiat Oncol Biol Phys 68(2):531–540

    Article  PubMed  Google Scholar 

  • Mackie TR, Holmes T, Swerdloff S, Reckwerdt P, Deasy JO, Yang J, Paliwal B, Kinsella T (1993) Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy. Med Phys 20(6):1709–1719

    Article  PubMed  CAS  Google Scholar 

  • Mageras GS, Yorke E, Rosenzweig K, Braban L, Keatley E, Ford E, Leibel SA, Ling CC (2001) Fluoroscopic evaluation of diaphragmatic motion reduction with a respiratory gated radiotherapy system. J Appl Clin Med Phys 2(4):191–200

    Article  PubMed  CAS  Google Scholar 

  • Mayles WP (2010) Radiotherapy Development Board Survey of the availability and use of advanced radiotherapy technology in the UK. Clin Oncol (R Coll Radiol) 22(8):636–642

    Article  CAS  Google Scholar 

  • Minohara S, Kanai T, Endo M, Noda K, Kanazawa M (2000) Respiratory gated irradiation system for heavy-ion radiotherapy. Int J Radiat Oncol Biol Phys 47(4):1097–1103

    Article  PubMed  CAS  Google Scholar 

  • Mori S, Endo M, Komatsu S, Yashiro T, Kandatsu S, Baba M (2007) Four-dimensional measurement of lung tumor displacement using 256-multi-slice CT-scanner. Lung Cancer 56(1):59–67

    Article  PubMed  Google Scholar 

  • Nagata Y, Wulf J, Lax I, Timmerman R, Zimmermann F, Stojkovski I, Jeremic B (2011) Stereotactic radiotherapy of primary lung cancer and other targets: results of consultant meeting of the International Atomic Energy Agency. Int J Radiat Oncol Biol Phys 79(3):660–669

    Article  PubMed  Google Scholar 

  • Nakamura M, Narita Y, Matsuo Y, Narabayashi M, Nakata M, Yano S, Miyabe Y, Matsugi K, Sawada A, Norihisa Y, Mizowaki T, Nagata Y, Hiraoka M (2008) Geometrical differences in target volumes between slow CT and 4D CT imaging in stereotactic body radiotherapy for lung tumors in the upper and middle lobe. Med Phys 35(9):4142–4148

    Article  PubMed  Google Scholar 

  • Ohara K, Okumura T, Akisada M, Inada T, Mori T, Yokota H, Calaguas MJ (1989) Irradiation synchronized with respiration gate. Int J Radiat Oncol Biol Phys 17(4):853–857

    Article  PubMed  CAS  Google Scholar 

  • Ong C, Verbakel WF, Cuijpers JP, Slotman BJ, Senan S (2011) Dosimetric impact of interplay effect on RapidArc lung stereotactic treatment delivery. Int J Radiat Oncol Biol Phys 79(1):305–311

    Article  PubMed  Google Scholar 

  • Palma D, Visser O, Lagerwaard FJ, Belderbos J, Slotman BJ, Senan S (2010) Impact of introducing stereotactic lung radiotherapy for elderly patients with stage I non-small-cell lung cancer: a population-based time-trend analysis. J Clin Oncol 28(35):5153–5159

    Article  PubMed  Google Scholar 

  • Pantarotto JR, Piet AH, Vincent A, de Koste JR, Senan S (2009) Motion analysis of 100 mediastinal lymph nodes: potential pitfalls in treatment planning and adaptive strategies. Int J Radiat Oncol Biol Phys 74(4):1092–1099

    Article  PubMed  Google Scholar 

  • Phernambucq EC, Spoelstra FO, Verbakel WF, Postmus PE, Melissant CF, Maassen van den Brink KI, Frings V, van de Ven PM, Smit EF, Senan S (2011) Outcomes of concurrent chemoradiotherapy in patients with stage III non-small-cell lung cancer and significant comorbidity. Ann Oncol 22(1):132–138

    Article  PubMed  CAS  Google Scholar 

  • Ragan DP, Perez CA (1978) Efficacy of CT-assisted two dimensional treatment planning: analysis of 45 patients. AJR Am J Roentgenol 131(1):75–79

    Article  PubMed  CAS  Google Scholar 

  • Redmond KJ, Song DY, Fox JL, Zhou J, Rosenzweig CN, Ford E (2009) Respiratory motion changes of lung tumors over the course of radiation therapy based on respiration-correlated four-dimensional computed tomography scans. Int J Radiat Oncol Biol Phys 75(5):1605–1612

    Article  PubMed  Google Scholar 

  • Riegel AC, Chang JY, Vedam SS, Johnson V, Chi PC, Pan T (2009) Cine computed tomography without respiratory surrogate in planning stereotactic radiotherapy for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 73(2):433–441

    Article  PubMed  Google Scholar 

  • Ritchie CJ, Hsieh J, Gard MF, Godwin JD, Kim Y, Crawford CR (1994) Predictive respiratory gating: a new method to reduce motion artifacts on CT scans. Radiology 190(3):847–852

    PubMed  CAS  Google Scholar 

  • Rosenzweig KE, Hanley J, Mah D, Mageras G, Hunt M, Toner S, Burman C, Ling CC, Mychalczak B, Fuks Z, Leibel SA (2000) The deep inspiration breath-hold technique in the treatment of inoperable non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 48(1):81–87

    Article  PubMed  CAS  Google Scholar 

  • Routsis D, Staffurth J, Beardmore C, Mackay R (2010) Radiotherapy Development Board Education and training for intensity-modulated radiotherapy in the UK. Clin Oncol (R Coll Radiol) 22(8):675–680

    Article  CAS  Google Scholar 

  • Sher DJ, Wolfgang JA, Niemierko A, Choi NC (2007) Quantification of mediastinal and hilar lymph node movement using four-dimensional computed tomography scan: implications for radiation treatment planning. Int J Radiat Oncol Biol Phys 69(5):1402–1408

    Article  PubMed  Google Scholar 

  • Shih HA, Jiang SB, Aljarrah KM, Doppke KP, Choi NC (2004) Internal target volume determined with expansion margins beyond composite gross tumor volume in three-dimensional conformal radiotherapy for lung cancer. Int J Radiat Oncol Biol Phys 60(2):613–622

    PubMed  Google Scholar 

  • Simpson DR, Lawson JD, Nath SK, Rose BS, Mundt AJ, Mell LK (2009) Utilization of advanced imaging technologies for target delineation in radiation oncology. J Am Coll Radiol 6(12):876–883

    Article  PubMed  Google Scholar 

  • Sirkin HL, Keenan P, Jackson A (2005) The hard side of change management. Harv Bus Rev 83(10):108–118 158

    PubMed  Google Scholar 

  • Slotman BJ, Lagerwaard FJ, Senan S (2006) 4D imaging for target definition in stereotactic radiotherapy for lung cancer. Acta Oncol 45(7):966–972

    Article  PubMed  Google Scholar 

  • Sonke JJ, Belderbos J (2010) Adaptive radiotherapy for lung cancer. Semin Radiat Oncol 20(2):94–106

    Article  PubMed  Google Scholar 

  • Sonke JJ, Zijp L, Remeijer P, van Herk M (2005) Respiratory correlated cone beam CT. Med Phys 32(4):1176–1186

    Article  PubMed  Google Scholar 

  • Spear SJ (2004) Learning to lead at Toyota. Harv Bus Rev 82(5):78–86 151

    PubMed  Google Scholar 

  • Sura S, Gupta V, Yorke E, Jackson A, Amols H, Rosenzweig KE (2008) Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: the Memorial Sloan-Kettering Cancer Center (MSKCC) experience. Radiother Oncol 87(1):17–23

    Article  PubMed  Google Scholar 

  • Taremi M, Hope A, Dahele M, Pearson S, Fung S, Purdie T, Brade A, Cho J, Sun A, Bissonnette JP, Bezjak A (2011) Stereotactic body radiotherapy for medically inoperable lung cancer: prospective, single-center study of 108 consecutive patients. Int J Radiat Oncol Biol Phys [Epub ahead of print]

    Google Scholar 

  • Underberg RW, Lagerwaard FJ, Cuijpers JP, Slotman BJ, de Koste JR, Senan S (2004) Four-dimensional CT scans for treatment planning in stereotactic radiotherapy for stage I lung cancer. Int J Radiat Oncol Biol Phys 60(4):1283–1290

    Article  PubMed  Google Scholar 

  • Underberg RW, Lagerwaard FJ, Slotman BJ, Cuijpers JP, Senan S (2005) Use of maximum intensity projections (MIP) for target volume generation in 4DCT scans for lung cancer. Int J Radiat Oncol Biol Phys 63(1):253–260

    Article  PubMed  Google Scholar 

  • van Dam IE, de Koste JR, Hanna GG, Muirhead R, Slotman BJ, Senan S (2010) Improving target delineation on 4 dimensional CT scans in stage I NSCLC using a deformable registration tool. Radiother Oncol 96(1):67–72

    Article  PubMed  Google Scholar 

  • van Elmpt W, Hamill J, Jones J, De Ruysscher D, Lambin P, Ollers M (2011) Optimal gating compared to 3D and 4D PET reconstruction for characterization of lung tumours. Eur J Nucl Med Mol Imaging 38(5):843–855

    Article  PubMed  Google Scholar 

  • Verbakel WF, Senan S, Cuijpers JP, Slotman BJ, Lagerwaard FJ (2009) Rapid delivery of stereotactic radiotherapy for peripheral lung tumors using volumetric intensity-modulated arcs. Radiother Oncol 93(1):122–124

    Article  PubMed  Google Scholar 

  • Verbakel W, Ladenius-Lischer I, Slotman BJ, Senan S (2010) A hybrid IMRT technique for high-dose radiotherapy in large-volume stage III lung tumors: planning comparison with 3 other techniques. Int J Radiat Oncol Biol Phys 78(3):S811 (A3357)

    Article  Google Scholar 

  • Verellen D, Depuydt T, Gevaert T, Linthout N, Tournel K, Duchateau M, Reynders T, Storme G, De Ridder M (2010) Gating and tracking, 4D in thoracic tumours. Cancer Radiother 14(6-7):446–454

    Article  PubMed  CAS  Google Scholar 

  • Wanet M, Lee JA, Weynand B, De Bast M, Poncelet A, Lacroix V, Coche E, Grégoire V, Geets X (2011) Gradient-based delineation of the primary GTV on FDG-PET in non-small cell lung cancer: a comparison with threshold-based approaches, CT and surgical specimens. Radiother Oncol 98(1):117–125

    Article  PubMed  Google Scholar 

  • Weiss E, Wijesooriya K, Dill SV, Keall PJ (2007) Tumor and normal tissue motion in the thorax during respiration: analysis of volumetric and positional variations using 4D CT. Int J Radiat Oncol Biol Phys 67(1):296–307

    Article  PubMed  Google Scholar 

  • Whitton A, Warde P, Sharpe M, Oliver TK, Bak K, Leszczynski K, Etheridge S, Fleming K, Gutierrez E, Favell L, Green E (2009) Organisational standards for the delivery of intensity-modulated radiation therapy in Ontario. Clin Oncol (R Coll Radiol) 21(3):192–203

    Article  CAS  Google Scholar 

  • Williams MV, Cooper T, Mackay R, Staffurth J, Routsis D, Burnet N (2010) The implementation of intensity-modulated radiotherapy in the UK. Clin Oncol (R Coll Radiol) 22(8):623–628

    Article  CAS  Google Scholar 

  • Wong JW, Sharpe MB, Jaffray DA, Kini VR, Robertson JM, Stromberg JS, Martinez AA (1999) The use of active breathing control (ABC) to reduce margin for breathing motion. Int J Radiat Oncol Biol Phys 44(4):911–919

    Article  PubMed  CAS  Google Scholar 

  • Yamada K, Soejima T, Yoden E, Maruta T, Okayama T, Sugimura K (2002) Improvement of three-dimensional treatment planning models of small lung targets using high-speed multi-slice computed tomographic imaging. Int J Radiat Oncol Biol Phys 54(4):1210–1216

    Article  PubMed  Google Scholar 

  • Yamamoto T, Langner U, Loo BW Jr, Shen J, Keall PJ (2008) Retrospective analysis of artifacts in four-dimensional CT images of 50 abdominal and thoracic radiotherapy patients. Int J Radiat Oncol Biol Phys 72(4):1250–1258

    Article  PubMed  Google Scholar 

  • Yeung AR, Li J, Shi W, Newlin H, Morris CG, Samant S, Saito A, Chvetsov A, Liu C, Palta J, Olivier K (2010) Optimal image-guidance scenario with cone-beam computed tomography in conventionally fractionated radiotherapy for lung tumors. Am J Clin Oncol 33(3):276–280

    PubMed  Google Scholar 

  • Yom SS, Liao Z, Liu HH, Tucker SL, Hu CS, Wei X, Wang X, Wang S, Mohan R, Cox JD, Komaki R (2007) Initial evaluation of treatment-related pneumonitis in advanced-stage non-small-cell lung cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 68(1):94–102

    Article  PubMed  CAS  Google Scholar 

  • Yu CX (1995) Intensity-modulated arc therapy with dynamic multileaf collimation: an alternative to tomotherapy. Phys Med Biol 40(9):1435–1449

    Article  PubMed  CAS  Google Scholar 

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Conflicts of interest

The Department of Radiation Oncology, VU University Medical Center has research collaborations with Varian Medical Systems Inc. (Palo Alto, CA, USA), Brainlab AG (Feldkirchen, Germany), Velocity Medical Solutions (Atlanta, GA, USA).

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  1. Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    Max Dahele, Johan Cuijpers & Suresh Senan

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  1. Max Dahele
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  2. Johan Cuijpers
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Correspondence to Max Dahele .

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  1. Institute of Lung Diseases, Institutski put 4, Sremska Kamenica, 21204, Serbia

    Branislav Jeremic

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Dahele, M., Cuijpers, J., Senan, S. (2011). Four-dimensional Radiation Therapy for Non-Small Cell Lung Cancer: A Clinical Perspective. In: Jeremic, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_284

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  • DOI: https://doi.org/10.1007/174_2011_284

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-19924-0

  • Online ISBN: 978-3-642-19925-7

  • eBook Packages: MedicineMedicine (R0)

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