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Re-irradiation: New Frontiers pp 143–153Cite as

Prostate Cancer

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Salvage radiotherapy for locally recurrent prostate cancer after primary radiation is generally performed by brachytherapy. Only a limited amount of small studies has been performed, all retrospective. In these studies the rate of severe toxicity was high and outcome was disappointing, and therefore, salvage treatments are not popular. Furthermore, it is unclear whether salvage treatment will improve disease-specific or overall survival. Salvage currently can be considered in patients with a pathology proven local recurrence after an interval of at least 2–3 years after primary treatment, together with a limited and non-aggressive tumor presentation at time of salvage. Currently, experienced groups recommend at least equal doses to primary treatment to the entire prostate. Current developments in PET and MRI imaging give the possibility to localize the macroscopic recurrent tumor in the prostate. This enables future focal salvage techniques which can be expected to reduce severe toxicity rates.

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  1. Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht,, The Netherlands

    Marco van Vulpen

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  1. Marco van Vulpen
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Correspondence to Marco van Vulpen .

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  1. , Dept. Internal Medicine, Nordlandssykehuset HF, Prinsensgate 164, Bodoe, 8092, Norway

    Carsten Nieder

  2. Department of Radiation Oncology, University Medical Center Groningen, Hanzeplein 1, Groningen, 9700 RB, Netherlands

    Johannes A. Langendijk

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van Vulpen, M. (2010). Prostate Cancer. In: Nieder, C., Langendijk, J. (eds) Re-irradiation: New Frontiers. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2010_74

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  • DOI: https://doi.org/10.1007/174_2010_74

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