Abstract
Since its beginnings, the main magnetic field strength of MR-systems has constantly been increased for high resolution spectrometers, small animal imaging systems and clinical MRI. The obvious motivation is the higher signal-to-noise ratio achievable. However, other effects that result from changes in the relaxation times, the ratio of the object extensions with respect to the RF wave length, or the deposited energy have to be considered. The basic physical effects and their consequences for the most common measurement methods, such as fast gradient echo, turbo spin echo and echo planar imaging are presented and discussed in this chapter.
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References
Ahn CB, Kim JH, Cho ZH (1986) High-speed spiral-scan echo planar NMR imaging-I. IEEE Trans Med Imaging 5:2–7
Alsop DC (1997) The sensitivity of low flip angle RARE imaging. Magn Reson Med 37:176–184
Andersson JL, Skare S (2002) A model-based method for retrospective correction of geometric distortions in diffusion-weighted EPI. Neuroimage 16:177–199
Atkinson D, Hill DL, Stoyle PN et al (1999) Automatic compensation of motion artifacts in MRI. Magn Reson Med 41:163–170
Bammer R, Aksoy M, Liu C (2007) Augmented generalized SENSE reconstruction to correct for rigid body motion. Magn Reson Med 57:90–102
Bangerter NK, Hargreaves BA, Vasanawala SS et al (2004) Analysis of multiple-acquisition SSFP. Magn Reson Med 51:1038–1047
Baudrexel S, Volz S, Preibisch C et al (2009) Rapid single-scan T 2*-mapping using exponential excitation pulses and image-based correction for linear background gradients. Magn Reson Med 62:263–268
Bernstein MA, Huston J 3rd, Ward HA (2006) Imaging artifacts at 3.0 T. J Magn Reson Imaging 24:735–746
Bieri O, Scheffler K (2006) On the origin of apparent low tissue signals in balanced SSFP. Magn Reson Med 56:1067–1074
Bulte JW, Kraitchman DL (2004) Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed 17:484–499
Busse RF (2004) Reduced RF power without blurring: correcting for modulation of refocusing flip angle in FSE sequences. Magn Reson Med 51:1031–1037
Busse RF, Hariharan H, Vu A et al (2006) Fast spin echo sequences with very long echo trains: design of variable refocusing flip angle schedules and generation of clinical T2 contrast. Magn Reson Med 55:1030–1037
Busse RF, Brau AC, Vu A et al (2008) Effects of refocusing flip angle modulation and view ordering in 3D fast spin echo. Magn Reson Med 60:640–649
Carr HY, Purcell EM (1954) Effects of diffusion on free precession in nuclear magnetic resonance experiments. Phys Rev 94:630–638
Casselman JW, Kuhweide R, Deimling M et al (1993) Constructive interference in steady state-3DFT MR imaging of the inner ear and cerebellopontine angle. AJNR 14:47–57
Chen Z, Johnston LA, Kwon DH et al (2010) An optimised framework for reconstructing and processing MR phase images. Neuroimage 49:1289–1300
Cho ZH, Ro YM, Park ST et al (1996) NMR functional imaging using a tailored RF gradient echo sequence: a true susceptibility measurement technique. Magn Reson Med 35:1–5
Collins CM, Li S, Smith MB (1998) SAR and B1 field distributions in a heterogeneous human head model within a birdcage coil. Specific energy absorption rate. Magn Reson Med 40:847–856
Constable RT, Spencer DD (1999) Composite image formation in z-shimmed functional MR imaging. Magn Reson Med 42:110–117
Constable RT, Anderson AW, Zhong J et al (1992) Factors influencing contrast in fast spin-echo MR imaging. Magn Reson Imaging 10:497–511
Deichmann R, Gottfried JA, Hutton C et al (2003) Optimized EPI for fMRI studies of the orbitofrontal cortex. Neuroimage 19:430–441
Derbyshire JA, Wright GA, Henkelman RM et al (1998) Dynamic scan-plane tracking using MR position monitoring. J Magn Reson Imaging 8:924–932
Dumoulin CL, Souza SP, Darrow RD (1993) Real-time position monitoring of invasive devices using magnetic resonance. Magn Reson Med 29:411–415
Duyn JH, van Gelderen P, Li TQ et al (2007) High-field MRI of brain cortical substructure based on signal phase. Proc Natl Acad Sci USA 104:11796–11801
Edelstein WA, Hutchison JM, Johnson G et al (1980) Spin warp NMR imaging and applications to human whole-body imaging. Phys Med Biol 25:751–756
Ehman RL, Felmlee JP (1989) Adaptive technique for high-definition MR imaging of moving structures. Radiology 173:255–263
Elliott AM, Bernstein MA, Ward HA et al (2007) Nonlinear averaging reconstruction method for phase-cycle SSFP. Magnetic resonance imaging 25:359–364
Feinberg DA, Hale JD, Watts JC et al (1986) Halving MR imaging time by conjugation: demonstration at 3.5 kG. Radiology 161:527–531
Fischer HW, Rinck PA, Van Haverbeke Y et al (1990) Nuclear relaxation of human brain gray and white matter: analysis of field dependence and implications for MRI. Magn Reson Med 16:317–334
Frahm J, Merboldt KD, Hanicke W (1993) Functional MRI of human brain activation at high spatial resolution. Magn Reson Med 29:139–144
Freeman R, Hill H (1971) Phase and intensity anomalities in Fourier transform NMR. J Magn Reson 4:366–383
Friston KJ, Ashburner J, Poline JB et al (1995) Spatial realignment and normalization of images. Hum Brain Mapp 2:165–189
Gieseke J, Wattjes M, Lutterbey G et al (2004) Ultra fast T2-weighted TSE sequences using flip angle sweep with half-fourier and SENSE at 3 T. Neuroradiology 46(Suppl 1):122
Glover GH (1999) 3D z-shim method for reduction of susceptibility effects in BOLD fMRI. Magn Reson Med 42:290–299
Glover GH, Lee AT (1995) Motion artifacts in fMRI: comparison of 2DFT with PR and spiral scan methods. Magn Reson Med 33:624–635
Glover GH, Noll DC (1993) Consistent projection reconstruction (CPR) techniques for MRI. Magn Reson Med 29:345–351
Gyngell M (1989) The steady-state signals in short-repetition-time sequences. J Magn Reson 81:474–483
Haacke EM, Xu Y, Cheng YC et al (2004) Susceptibility weighted imaging (SWI). Magn Reson Med 52:612–618
Haake E, Brown R, Thompson M et al (1999) Fast imaging in the steady state. In: Haacke E, Brown R, Thompson M, Venkatesan R (eds) Magnetic resonance imaging: physical principles and sequence design, Wiley, New York, pp 451–512
Hahn EL (1950) Spin echoes. Phys Rev 80:580–594
He X, Yablonskiy DA (2009) Biophysical mechanisms of phase contrast in gradient echo MRI. Proc Natl Acad Sci USA 106:13558–13563
Henkelman RM, Hardy PA, Bishop JE et al (1992) Why fat is bright in RARE and fast spin-echo imaging. J Magn Reson Imaging 2:533–540
Hennig J (1988) Multiecho imaging sequences with low refocusing flip angles. J Magn Reson 78:397–407
Hennig J (1991) Echoes—How to generate, recognize, use or avoid them in MR-imaging sequences. Part I + II. Concepts Magn Reson 3:125–143, 179–192
Hennig J, Scheffler K (2000) Easy improvement of signal-to-noise in RARE-sequences with low refocusing flip angles. Magn Reson Med 44:983–985
Hennig J, Scheffler K (2001) Hyperechoes. Magn Reson Med 46:6–12
Hennig J, Nauerth A, Friedburg H (1986) RARE imaging: a fast imaging method for clinical MR. Magn Reson Med 3:823–833
Hennig J, Weigel M, Scheffler K (2003) Multiecho sequences with variable refocusing flip angles: optimization of signal behavior using smooth transitions between pseudo steady states (TRAPS). Magn Reson Med 49:527–535
Hennig J, Weigel M, Scheffler K (2004) Calculation of flip angles for echo trains with predefined amplitudes with the extended phase graph (EPG)-algorithm: principles and applications to hyperecho and TRAPS sequences. Magn Reson Med 51:68–80
Himmelreich U, Dresselaers T (2009) Cell labeling and tracking for experimental models using magnetic resonance imaging. Methods 48:112–124
Hoffmann MB, Stadler J, Kanowski M et al (2009) Retinotopic mapping of the human visual cortex at a magnetic field strength of 7 T. Clin Neurophysiol 120:108–116
Hoult DI, Phil D (2000) Sensitivity and power deposition in a high-field imaging experiment. J Magn Reson Imaging 12:46–67
Jezzard P, Balaban RS (1995) Correction for geometric distortion in echo planar images from B0 field variations. Magn Reson Med 34:65–73
Jezzard P, Duewell S, Balaban RS (1996) MR relaxation times in human brain: measurement at 4 T. Radiology 199:773–779
Kaiser R, Bartholdi E, Ernst R (1974) Diffusion and field-gradient effects in NMR Fourier spectroscopy. J Chem Phys 60:2057–2061
Katscher U, Bornert P, Leussler C et al (2003) Transmit SENSE. Magn Reson Med 49:144–150
Kiefer B, Grässner J, Hausmann R (1994) Image acquisition in a second with half-Fourier-acquisition single-shot turbo spin echo. J Magn Reson Imaging 4:86
Kim B, Boes JL, Bland PH et al (1999) Motion correction in fMRI via registration of individual slices into an anatomical volume. Magn Reson Med 41:964–972
Koenig SH, Brown RD 3rd, Adams D et al (1984) Magnetic field dependence of 1/T 1 of protons in tissue. Invest Radiol 19:76–81
Kumar A, Welti I, Ernst RR (1975) NMR Fourier zeugmatography. J Magn Reson 18:69–83
Kwong KK, Belliveau JW, Chesler DA et al (1992) Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 89:5675–5679
Lauterbur PC (1973) Image formation by induced local interactions: examples employing nuclear magnetic resonance. Nature 242:190–191
Lauterbur PC (1974) Magnetic resonance zeugmatography. Pure Appl Chem 40:149–157
Le Roux P, Hinks RS (1993) Stabilization of echo amplitudes in FSE sequences. Magn Reson Med 30:183–190
Lebel RM, Wilman AH (2007) Intuitive design guidelines for fast spin echo imaging with variable flip angle echo trains. Magn Reson Med 57:972–975
Lebel RM, Wilman AH (2009) Time-efficient fast spin echo imaging at 4.7 T with low refocusing angles. Magn Reson Med 62:96–105
Li TQ, van Gelderen P, Merkle H et al (2006) Extensive heterogeneity in white matter intensity in high-resolution T 2*-weighted MRI of the human brain at 7.0 T. Neuroimage 32:1032–1040
Liu C, Bammer R, Kim DH et al (2004) Self-navigated interleaved spiral (SNAILS): application to high-resolution diffusion tensor imaging. Magn Reson Med 52:1388–1396
Luo J, He X, d’Avignon DA et al (2010) Protein-induced water 1H MR frequency shifts: contributions from magnetic susceptibility and exchange effects. J Magn Reson 202:102–108
Maclaren J, Speck O, Stucht D et al (2010) Navigator accuracy requirements for prospective motion correction. Magn Reson Med 63:162–170
Mansfield P (1984) Real-time echo-planar imaging by NMR. Br Med Bull 40:187–190
Mansfield P, Maudsley AA (1977) Planar spin imaging by NMR. J Magn Reson 27:101–119
Mao W, Smith MB, Collins CM (2006) Exploring the limits of RF shimming for high-field MRI of the human head. Magn Reson Med 56:918–922
Martin WR, Wieler M, Gee M (2008) Midbrain iron content in early Parkinson disease: a potential biomarker of disease status. Neurology 70:1411–1417
Meiboom S, Gill D (1958) Modified spin-echo method for measuring nuclear relaxation times. Rev Sci Instrum 29:688–691
Melki PS, Mulkern RV, Panych LP et al (1991) Comparing the FAISE method with conventional dual-echo sequences. J Magn Reson Imaging 1:319–326
Melki PS, Jolesz FA, Mulkern RV (1992) Partial RF echo-planar imaging with the FAISE method. II. Contrast equivalence with spin-echo sequences. Magn Reson Med 26:342–354
Michaeli S, Garwood M, Zhu XH et al (2002) Proton T 2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr–Purcell spin echoes at 4 T and 7 T. Magn Reson Med 47:629–633
Morgan PS, Bowtell RW, McIntyre DJ et al (2004) Correction of spatial distortion in EPI due to inhomogeneous static magnetic fields using the reversed gradient method. J Magn Reson Imaging 19:499–507
Mugler JP (2007) Signal and contrast properties of very-long spin-echo trains for 3D T2-weighted turbo-spin-echo imaging; Berlin, Germany, p 1716
Mugler JP, Bao S, Mulkern RV et al (2000a) Optimized single-slab three-dimensional spin-echo MR imaging of the brain. Radiology 216:891–899
Mugler JP, Kiefer B, Brookeman JR (2000b) Three-dimensional T2-weighted imaging of the brain using very long spin-echo trains, Denver, USA, p 687
Mugler JP, Wald LL, Brookeman JR (2001) T2-weighted 3D spin-echo train imaging of the brain at 3 Tesla: reduced power deposition using low flip-angle refocusing RF pulses. 2001; Glasgow, United Kingdom, p 438
Mulkern RV, Wong ST, Winalski C et al (1990) Contrast manipulation and artifact assessment of 2D and 3D RARE sequences. Magn Reson Imaging 8:557–566
Mulkern RV, Melki PS, Jakab P et al (1991) Phase-encode order and its effect on contrast and artifact in single-shot RARE sequences. Med Phys 18:1032–1037
Noll DC (1997) Multishot rosette trajectories for spectrally selective MR imaging. IEEE Trans Med Imaging 16:372–377
Ogawa S, Lee TM, Kay AR et al (1990) Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 87:9868–9872
Ooi MB, Krueger S, Thomas WJ et al (2009) Prospective real-time correction for arbitrary head motion using active markers. Magn Reson Med 62:943–954
Ordidge RJ, Gorell JM, Deniau JC et al (1994) Assessment of relative brain iron concentrations using T 2-weighted and T 2*-weighted MRI at 3 Tesla. Magn Reson Med 32:335–341
Oshio K, Feinberg DA (1991) GRASE (Gradient- and spin-echo) imaging: a novel fast MRI technique. Magn Reson Med 20:344–349
Patel MR, Klufas RA, Alberico RA et al (1997) Half-fourier acquisition single-shot turbo spin-echo (HASTE) MR: comparison with fast spin-echo MR in diseases of the brain. AJNR Am J Neuroradiol 18:1635–1640
Pipe JG (1999) Motion correction with PROPELLER MRI: application to head motion and free-breathing cardiac imaging. Magn Reson Med 42:963–969
Pruessmann KP, Weiger M, Scheidegger MB et al (1999) SENSE: sensitivity encoding for fast MRI. Magn Reson Med 42:952–962
Qin L, van Gelderen P, Derbyshire JA et al (2009) Prospective head-movement correction for high-resolution MRI using an in-bore optical tracking system. Magn Reson Med 62:924–934
Reichenbach JR, Venkatesan R, Schillinger DJ et al (1997) Small vessels in the human brain: MR venography with deoxyhemoglobin as an intrinsic contrast agent. Radiology 204:272–277
Robson MD, Gore JC, Constable RT (1997) Measurement of the point spread function in MRI using constant time imaging. Magn Reson Med 38:733–740
Rooney WD, Johnson G, Li X et al (2007) Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo. Magn Reson Med 57:308–318
Rosen BR, Belliveau JW, Vevea JM et al (1990) Perfusion imaging with NMR contrast agents. Magn Reson Med 14:249–265
Scheffler K (1999) A pictorial description of steady-states in rapid magnetic resonance imaging. Concepts Magn Reson 11:291–304
Scheffler K, Seifritz E, Bilecen D et al (2001) Detection of BOLD changes by means of a frequency-sensitive trueFISP technique: preliminary results. NMR Biomed 14:490–496
Sobol WT, Gauntt DM (1996) On the stationary states in gradient echo imaging. J Magn Reson Imaging 6:384–398
Sodickson DK, Manning WJ (1997) Simultaneous acquisition of spatial harmonics (SMASH): fast imaging with radiofrequency coil arrays. Magn Reson Med 38:591–603
Speck O (2005) Spin-echo based T1-contrast at 3 T: the problem and a simple solution. Proceedings of the 13th Annual Meeting of the ISMRM, Miami Beach, USA, p 2197
Speck O, Hennig J, Zaitsev M (2006) Prospective real-time slice-by-slice motion correction for fMRI in freely moving subjects. MAGMA 19:55–61
Speck O, Stadler J, Zaitsev M (2008) High resolution single-shot EPI at 7 T. MAGMA 21:73–86
Stenger VA, Boada FE, Noll DC (2000) Three-dimensional tailored RF pulses for the reduction of susceptibility artifacts in T(*)(2)-weighted functional MRI. Magn Reson Med 44:525–531
Tetzlaff RH, Mader I, Kuker W et al (2008) Hyperecho-turbo spin-echo sequences at 3 T: clinical application in neuroradiology. AJNR Am J Neuroradiol 29:956–961
Thesen S, Heid O, Mueller E et al (2000) Prospective acquisition correction for head motion with image-based tracking for real-time fMRI. Magn Reson Med 44:457–465
Weigel M, Hennig J (2006) Contrast behavior and relaxation effects of conventional and hyperecho-turbo spin echo sequences at 1.5 and 3 T. Magn Reson Med 55:826–835
Weigel M, Hennig J (2008) Development and optimization of T2 weighted methods with reduced RF power deposition (Hyperecho-TSE) for magnetic resonance imaging. Zeitschrift fur medizinische Physik 18:151–161
Weigel M, Zaitsev M, Hennig J (2007) Inversion recovery prepared turbo spin echo sequences with reduced SAR using smooth transitions between pseudo steady states. Magn Reson Med 57:631–637
Welch EB, Felmlee JP, Ehman RL et al (2002a) Motion correction using the k-space phase difference of orthogonal acquisitions. Magn Reson Med 48:147–156
Welch EB, Manduca A, Grimm RC et al (2002b) Spherical navigator echoes for full 3D rigid body motion measurement in MRI. Magn Reson Med 47:32–41
Wesbey GE, Moseley ME, Ehman RL (1984a) Translational molecular self-diffusion in magnetic resonance imaging. I. Effects on observed spin-spin relaxation. Invest Radiol 19:484–490
Wesbey GE, Moseley ME, Ehman RL (1984b) Translational molecular self-diffusion in magnetic resonance imaging. II. Measurement of the self-diffusion coefficient. Invest Radiol 19:491–498
Williamson DS, Mulkern RV, Jakab PD et al (1996) Coherence transfer by isotropic mixing in Carr–Purcell–Meiboom–Gill imaging: implications for the bright fat phenomenon in fast spin-echo imaging. Magn Reson Med 35:506–513
Woessner DE (1961) Effects of diffusion in nuclear magnetic resonance spin-echo experiments. J Chem Phys 34:2057–2061
Zaitsev M, Hennig J, Speck O (2004) Point spread function mapping with parallel imaging techniques and high acceleration factors: fast, robust, and flexible method for echo-planar imaging distortion correction. Magn Reson Med 52:1156–1166
Zaitsev M, Dold C, Sakas G et al (2006) Magnetic resonance imaging of freely moving objects: prospective real-time motion correction using an external optical motion tracking system. Neuroimage 31:1038–1050
Zeng H, Constable RT (2002) Image distortion correction in EPI: comparison of field mapping with point spread function mapping. Magn Reson Med 48:137–146
Zhong K, Leupold J, von Elverfeldt D et al (2008) The molecular basis for gray and white matter contrast in phase imaging. Neuroimage 40:1561–1566
Zur Y, Wood ML, Neuringer LJ (1991) Spoiling of transverse magnetization in steady-state sequences. Magn Reson Med 21:251–263
Zur Y, Stokar S, Bendel P (1988) An analysis of fast imaging sequences with steady-state transverse magnetization refocusing. Magn Reson Med 6:175–193
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Speck, O., Weigel, M., Scheffler, K. (2012). Contrasts, Mechanisms and Sequences. In: Hennig, J., Speck, O. (eds) High-Field MR Imaging. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2010_101
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