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Polymer Libraries pp 17–62Cite as

Parallel Optimization and High-Throughput Preparation of Well-Defined Copolymer Libraries Using Controlled/“Living” Polymerization Methods

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Part of the book series: Advances in Polymer Science ((POLYMER,volume 225))

Abstract

This chapter highlights the application of controlled/“living” polymerization (CLP) techniques in automated parallel synthesizers for both optimizing reaction parameters as well as preparing copolymer libraries. Special attention is given to the use of CLP techniques for constructing well-defined copolymer libraries. Furthermore, alternative strategies for the preparation of block copolymer libraries are discussed.

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Abbreviations

AA:

Acrylic acid

AcBr:

Acetyl bromide

AcCl:

Acetyl chloride

AcI:

Acetyl iodide

AFM:

Atomic force microscopy

AIBN:

α,α-Azobisisobutyronitrile

Amor:

N-Acryoyl morpholine

ATRP:

Atom transfer radical polymerization

BEB:

(1-Bromo ethyl) benzene

bpy:

4, 4′-Dialkyl substituted bipyridine

BrEBiB:

2-Bromo-2-methylpropanoyl bromide

CBDB:

2-Cyano-2-butyl dithio benzoate

CLP:

Controlled/“living” polymerization

CROP:

Cationic ring opening polymerization

CRP:

Controlled radical polymerization

CTA:

Chain transfer agent

DMA:

N,N-Dimethyl acrylamide

DMAc:

N,N-Dimethyl acetamide

DMAEMA:

N,N-Dimethyl aminoethyl acrylamide

DMF:

N,N-Dimethyl formamide

DP:

Degree of polymerization

DSC:

Differential scanning calorimetry

EEA:

1-Ethoxy ethyl acrylate

EBIB:

Ethyl-2-bromo-iso-butyrate

EtOx:

2-Ethyl-2-oxazoline

GC:

Gas chromatography

HPA:

2-Hydoxypropyl acrylate

iPrOx:

2-iso-Propyl-2-oxazoline

LCST:

Lower critical solution temperature

MA:

Methyl acrylate

MAA:

Methacrylic acid

MADIX:

Macromolecular design via the interchange of xanthates

MBP:

Methyl bromo propionate

MMA:

Methyl methacrylate

MeOMA:

2-Methoxyethyl 2-methylacrylate

MeO2MA:

2-(2-Methoxyethoxy)ethyl 2-methylacrylate

MeOx:

2-Methyl-2-oxazoline

M n :

Number average molar mass

nBA:

n-Butyl acrylate

NIPAM:

N-Isopropyl acrylamide

NMP:

Nitroxide mediated polymerization

NMR:

Nuclear magnetic resonance

NonOx:

2-Nonyl-2-oxazoline

OEGMA:

Oligo(ethyleneglycol) methyl ether methacrylate

OEGEMA:

Oligo(ethylene glycol) ethyl ether methacrylate

PAA:

Poly(acrylic acid)

PDI:

Polydispersity index

PEEA:

Poly(1-ethoxyethyl acrylate)

PEG:

Poly(ethyleneglycol)

PEO:

Poly(ethylene oxide)

PheOx:

2-Phenyl-2-oxazoline

PDMAEMA:

Poly(N,N-dimethyl aminoethyl methacrylate)

PMA:

Poly(methyl acrylate)

PMMA:

Poly(methyl methacrylate)

PnBA:

Poly(n-butyl acrylate)

PSt:

Poly(styrene)

PtBA:

Poly(tert-butyl acrylate)

RAFT:

Reversible addition-fragmentation chain transfer

SEC:

Size exclusion chromatography

s-BuLi:

sec-Butyllithium

SPE:

Solid phase extraction

SoyOx:

2-“Soyalkyl”-2-oxazoline

St:

Styrene

tBA:

tert-Butyl acrylate

TEMPO:

2,2,6,6-Tetramethyl-1-piperidinyloxy stable radical

Tg :

Glass transition temperature

TGA:

Thermal gravimetric analysis

TsCl:

p-Toluene sulfonyl chloride

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Acknowledgement

Financial support from the Dutch Polymer Institute (DPI project #502) is gratefully acknowledged.

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Authors and Affiliations

  1. Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology, Den Dolech 2, 5612, AZ, Eindhoven, The Netherlands

    C. Remzi Becer & Ulrich S. Schubert

  2. Laboratory of Organic and Macromolecular Chemistry, Friedrich-Schiller-University Jena, Humboldtstr., 10, 07743, Jena, Germany

    C. Remzi Becer & Ulrich S. Schubert

  3. Dutch Polymer Institute, John F. Kennedylaan 2, 5612, AB, Eindhoven, The Netherlands

    C. Remzi Becer & Ulrich S. Schubert

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  1. C. Remzi Becer
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  2. Ulrich S. Schubert
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Correspondence to Ulrich S. Schubert .

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Editors and Affiliations

  1. FB Technik (T1116), FH Oldenburg, Constantiaplatz 4, Emden, 26723, Germany

    Michael A. R. Meier

  2. Dept. Coatings & Polymeric Materials, North Dakota State University, Fargo, 58105, USA

    Dean C. Webster

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Becer, C.R., Schubert, U.S. (2010). Parallel Optimization and High-Throughput Preparation of Well-Defined Copolymer Libraries Using Controlled/“Living” Polymerization Methods. In: Meier, M., Webster, D. (eds) Polymer Libraries. Advances in Polymer Science, vol 225. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2009_16

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