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Aminoacyl-tRNA Synthetases in Biology and Medicine pp 119–144Cite as

Protein–Protein Interactions and Multi-component Complexes of Aminoacyl-tRNA Synthetases

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Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 344))

Abstract

Protein–protein interaction occurs transiently or stably when two or more proteins bind together to mediate a wide range of cellular processes such as protein modification, signal transduction, protein trafficking, and structural folding. The macromolecules involved in protein biosynthesis such as aminoacyl-tRNA synthetase (ARS) have a number of protein–protein interactions. The mammalian multi-tRNA synthetase complex (MSC) consists of eight different enzymes: EPRS, IRS, LRS, QRS, MRS, KRS, RRS, and DRS, and three auxiliary proteins: AIMP1/p43, AIMP2/p38, and AIMP/p18. The distinct ARS proteins are also connected to diverse protein networks to carry out biological functions. In this chapter we first show the protein networks of the entire MSC and explain how MSC components interact with or can regulate other proteins. Finally, it is pointed out that the understanding of protein–protein interaction mechanism will provide insight to potential therapeutic application for diseases related to the MSC network.

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References

  1. Eriani G, Delarue M, Poch O, Gangloff J, Moras D (1990) Nature 347:203

    Article  CAS  Google Scholar 

  2. Burbaum JJ, Schimmel P (1991) J Biol Chem 266:16965

    CAS  Google Scholar 

  3. Cusack S, Hartlein M, Leberman R (1991) Nucleic Acids Res 19:3489

    Article  CAS  Google Scholar 

  4. Robinson JC, Kerjan P, Mirande M (2000) J Mol Biol 304:983

    Article  CAS  Google Scholar 

  5. Kim JY, Kang YS, Lee JW, Kim HJ, Ahn YH, Park H, Ko YG, Kim S (2002) Proc Natl Acad Sci USA 99:7912

    Article  CAS  Google Scholar 

  6. Ko YG, Park H, Kim S (2002) Proteomics 2:1304

    Article  CAS  Google Scholar 

  7. Simos G, Segref A, Fasiolo F, Hellmuth K, Shevchenko A, Mann M, Hurt EC (1996) EMBO J 5:5437

    Google Scholar 

  8. Galani K, Grosshans H, Deinert K, Hurt EC, Simos G (2001) EMBO J 20:6889

    Article  CAS  Google Scholar 

  9. Christine K, Adam R, Hannes S, Dietrich S, Dmitri S (2013) Nucleic Acids Res 41:667

    Article  CAS  Google Scholar 

  10. Lee SW, Cho BH, Park SG, Kim S (2004) J Cell Sci 117:3725

    Article  CAS  Google Scholar 

  11. Havrylenko S, Legouis R, Negrutskii B, Mirande M (2011) J Biol Chem 286:28476

    Article  CAS  Google Scholar 

  12. Norcum MT (1989) J Biol Chem 264:15043

    CAS  Google Scholar 

  13. Norcum MT, Boisset N (2002) FEBS Lett 512:298

    Article  CAS  Google Scholar 

  14. Wolfe CL, Warrington JA, Davis S, Green S, Norcum MT (2003) Protein Sci 12:2282

    Article  CAS  Google Scholar 

  15. Park SG, Schimmel P, Kim S (2008) Proc Natl Acad Sci USA 105:11043

    Article  Google Scholar 

  16. Han JM, Lee MJ, Park SG, Lee SH, Razin E, Choi EC, Kim S (2006) J Biol Chem 281:38663

    Article  CAS  Google Scholar 

  17. Kim JY, Kang YS, Lee JW, Kim HJ, Ahn YH, Park H, Ko YG, Kim S (2002) Proc Natl Acad Sci USA 99:7912

    Article  CAS  Google Scholar 

  18. Quevillon S, Mirande M (1996) FEBS Lett 395:63

    Article  CAS  Google Scholar 

  19. Quevillon S, Robinson JC, Berthonneau E, Siatecka M, Mirande M (1999) J Mol Biol 285:183

    Article  CAS  Google Scholar 

  20. Galani K, Grosshans H, Deinert K, Hurt EC, Simos G (2001) EMBO J 20:6889

    Article  CAS  Google Scholar 

  21. Sampath P, Mazumder B, Seshadri V, Gerber CA, Chavatte L, Kinter M, Ting SM, Dignam JD, Kim S, Driscoll DM, Fox PL (2004) Cell 119:195

    Article  CAS  Google Scholar 

  22. Jia J, Arif A, Ray PS, Fox PL (2008) Mol Cell 29:679

    Article  CAS  Google Scholar 

  23. Ray PS, Jia J, Yao P, Majumder M, Hatzoglou M, Fox PL (2009) Nature 457:915

    Article  CAS  Google Scholar 

  24. Arif A, Jia J, Moodt RA, DiCorleto PE, Fox PL (2011) Proc Natl Acad Sci USA 108:1415

    Article  Google Scholar 

  25. Yao P, Potdar AA, Arif A, Ray PS, Mukhopadhyay R, Willard B, Xu Y, Yan J, Saidel GM, Fox PL (2012) Cell 149:88

    Article  CAS  Google Scholar 

  26. Kim DG, Choi JW, Lee JY, Kim H, Oh YS, Lee JW, Tak YK, Song JM, Razin E, Yun SH, Kim S (2012) FASEB J 26:4142

    Article  CAS  Google Scholar 

  27. Ofir-Birin Y, Fang P, Bennett SP, Zhang HM, Wang J, Rachmin I, Shapiro R, Song J, Dagan A, Pozo J, Kim S, Marshall AG, Schimmel P, Yang XL, Nechushtan H, Razin E, Guo M (2013) Mol Cell 49:30

    CAS  Google Scholar 

  28. Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E (2009) Mol Cell 34:603

    Article  CAS  Google Scholar 

  29. Han JM, Park BJ, Park SG, Oh YS, Choi SJ, Lee SW, Hwang SK, Chang SH, Cho MH, Kim S (2008) Proc Natl Acad Sci USA 105:11206

    Article  Google Scholar 

  30. Kwon NH, Kang T, Lee JY, Kim HH, Kim HR, Hong J, Oh YS, Han JM, Ku MJ, Lee SY, Kim S (2011) Proc Natl Acad Sci USA 108:19635

    Article  Google Scholar 

  31. Negrutskii BS, Deutscher MP (1991) Proc Natl Acad Sci USA 88:4991

    Article  CAS  Google Scholar 

  32. Negrutskii BS, Deutscher MP (1992) Proc Natl Acad Sci USA 89:3601

    Article  CAS  Google Scholar 

  33. Kyriacou SV, Deutscher MP (2008) Mol Cell 29:419

    Article  CAS  Google Scholar 

  34. Shin BS, Kim JR, Walker SE, Dong J, Lorsch JR, Dever TE (2011) Nat Struct Mol Biol 18:1227

    Article  CAS  Google Scholar 

  35. Lee JS, Park SG, Park H, Seol W, Lee S, Kim S (2002) Biochem Biophys Res Commun 291:158

    Article  CAS  Google Scholar 

  36. Facciponte JG, Wang XY, MacDonald IJ, Park JE, Arnouk H, Grimm MJ, Li Y, Kim H, Manjili MH, Easton DP, Subjeck JR (2006) Cancer Immunol Immunother 55:339

    Article  CAS  Google Scholar 

  37. Hilf N, Singh-Jasuja H, Schild H (2002) Int J Hyperthermia 18:521

    Article  CAS  Google Scholar 

  38. Manjili MH, Wang XY, Park J, Facciponte JG, Repasky EA, Subjeck JR (2002) Front Biosci 7:d43

    Article  CAS  Google Scholar 

  39. Han JM, Park SG, Liu B, Park BJ, Kim JY, Jin CH, Song YW, Li Z, Kim S (2007) Am J Pathol 170:2042

    Article  CAS  Google Scholar 

  40. Schild H, Rammensee HG (2000) Nat Immunol 1:100

    Article  CAS  Google Scholar 

  41. Nicchitta CV (1998) Curr Opin Immunol 10:103

    Article  CAS  Google Scholar 

  42. Kijimoto-Ochiai S (2002) Cell Mol Life Sci 59:648

    Article  CAS  Google Scholar 

  43. Conrad DH, Kilmon MA, Studer EJ, Cho S (1997) Biochem Soc Trans 25:393

    CAS  Google Scholar 

  44. Mossalayi MD, Arock M, Debré P (1997) Int Rev Immunol 16:129

    Article  CAS  Google Scholar 

  45. Kwon HS, Park MC, Kim DG, Cho K, Park YW, Han JM, Kim S (2012) J Cell Sci 125:4620

    Article  CAS  Google Scholar 

  46. Lee YS, Han JM, Son SH, Choi JW, Jeon EJ, Bae SC, Park YI, Kim S (2008) Biochem Biophys Res Commun 371:395

    Article  CAS  Google Scholar 

  47. Lee SW, Kim G, Kim S (2008) Exp Opin Drug Discov 3:945

    Article  CAS  Google Scholar 

  48. Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL (2001) Nat Cell Biol 3:587

    Article  CAS  Google Scholar 

  49. Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL (2000) Mol Cell 6:1365

    Article  CAS  Google Scholar 

  50. Kim MJ, Park BJ, Kang YS, Kim HJ, Park JH, Kang JW, Lee SW, Han JM, Lee HW, Kim S (2003) Nat Genet 34:330

    Article  CAS  Google Scholar 

  51. Liu J, Chung HJ, Vogt M, Jin Y, Malide D, He L, Dundr M, Levens D (2011) EMBO J 30:846

    Article  CAS  Google Scholar 

  52. Zhang J, Chen QM (2012) Oncogene 2012 32:2907

    Google Scholar 

  53. Choi JW, Kim DG, Park MC, Um JY, Han JM, Park SG, Choi EC, Kim S (2009) J Cell Sci 122:2710

    Article  CAS  Google Scholar 

  54. Magis C, van der Sloot AM, Serrano L, Notredame C (2012) Trends Biochem Sci 37:353

    Article  CAS  Google Scholar 

  55. Shen HM, Pervaiz S (2006) FASEB J 20:1589

    Article  CAS  Google Scholar 

  56. Bosari S, Viale G (1995) Virchows Arch 427:229

    Article  CAS  Google Scholar 

  57. Louis DN (1994) J Neuropathol Exp Neurol 53:11

    Article  CAS  Google Scholar 

  58. Mayo LD, Donner DB (2002) Trends Biochem Sci 27:462

    Article  CAS  Google Scholar 

  59. Daujat S, Neel H, Piette J (2001) Trends Genet 17:459

    Article  CAS  Google Scholar 

  60. Choi JW, Lee JW, Kim JK, Jeon HK, Choi JJ, Kim DG, Kim BG, Nam DH, Kim HJ, Yun SH, Kim S (2012) J Mol Cell Biol 4:164

    Article  CAS  Google Scholar 

  61. Park BJ, Kang JW, Lee SW, Choi SJ, Shin YK, Ahn YH, Choi YH, Choi D, Lee KS, Kim S (2005) Cell 120:209

    Article  CAS  Google Scholar 

  62. Park BJ, Oh YS, Park SY, Choi SJ, Rudolph C, Schlegelberger B, Kim S (2006) Cancer Res 66:6913

    Article  CAS  Google Scholar 

  63. Zhou J, Lim CU, Li JJ, Cai L, Zhang Y (2006) Cancer Lett 243:9

    Article  CAS  Google Scholar 

  64. Meulmeester E, Pereg Y, Shiloh Y, Jochemsen AG (2005) Cell Cycle 4:1166

    Article  CAS  Google Scholar 

  65. Caspari T (2000) Curr Biol 10:R315

    Article  CAS  Google Scholar 

  66. Oh YS, Kim DG, Kim G, Choi EC, Kennedy BK, Suh Y, Park BJ, Kim S (2010) Aging Cell 9:810

    Article  CAS  Google Scholar 

  67. Moir RD, Spann TP (2001) Cell Mol Life Sci 58:1748

    Article  CAS  Google Scholar 

  68. Ho CY, Lammerding J (2012) J Cell Sci 125:2087

    Article  CAS  Google Scholar 

  69. Pereira S, Bourgeois P, Navarro C, Esteves-Vieira V, Cau P, De Sandre-Giovannoli A, Lévy N (2008) Mech Ageing Dev 129:449

    Article  CAS  Google Scholar 

  70. Kang T, Kwon NH, Lee JY, Park MC, Kang E, Kim HH, Kang TJ, Kim S (2012) J Mol Biol 423:475

    Article  CAS  Google Scholar 

  71. Mohammad-Qureshi SS, Jennings MD, Pavitt GD (2008) Biochem Soc Trans 36:658

    Article  CAS  Google Scholar 

  72. Mbazima V, Da Costa DB, Omar A, Jovanovic K, Weiss SF (2010) Front Biosci 15:1150

    Article  CAS  Google Scholar 

  73. Rea VE, Rossi FW, De Paulis A, Ragno P, Selleri C, Montuori N (2012) Infez Med 20:8

    Google Scholar 

  74. Carmi-Levy I, Yannay-Cohen N, Kay G, Razin E, Nechushtan H (2008) Mol Cell Biol 28:5777

    Article  CAS  Google Scholar 

  75. Saadatmand J, Kleiman L (2012) Virus Res 169:340

    Article  CAS  Google Scholar 

  76. Javanbakht H, Halwani R, Cen S, Saadatmand J, Musier-Forsyth K, Gottlinger H, Kleiman L (2003) J Biol Chem 278:27644

    Article  CAS  Google Scholar 

  77. Stark LA, Hay RT (1998) J Virol 72:3037

    CAS  Google Scholar 

  78. Sheng Y, Chattopadhyay M, Whitelegge J, Valentine JS (2012) Curr Top Med Chem 12:2560

    Article  CAS  Google Scholar 

  79. Kunst CB, Mezey E, Brownstein MJ, Patterson D (1997) Nat Genet 15:91

    Article  CAS  Google Scholar 

  80. Kawamata H, Magrané J, Kunst C, King MP, Manfredi G (2008) J Biol Chem 283:28321

    Article  CAS  Google Scholar 

  81. Bec G, Kerjan P, Zha XD, Waller JP (1989) J Biol Chem 264:21131

    CAS  Google Scholar 

  82. Bec G, Kerjan P, Waller JP (1994) J Biol Chem 269:2086

    CAS  Google Scholar 

  83. Negrutskii BS, Shalak VF, Kerjan P, El’skaya AV, Mirande M (1999) J Biol Chem 274:4545

    Article  CAS  Google Scholar 

  84. Galani K, Grosshans H, Deinert K, Hurt EC, Simos G (2001) EMBO J 20:6889

    Article  CAS  Google Scholar 

  85. Wu H, Shi Y, Lin Y, Qian W, Yu Y, Huo K (2011) Mol Cell Biochem 357:209

    Article  CAS  Google Scholar 

  86. Fujisawa T, Takeda K, Ichijo H (2007) Mol Biotechnol 37:13

    Article  CAS  Google Scholar 

  87. Takeda K, Matsuzawa A, Nishitoh H, Ichijo H (2003) Cell Struct Funct 28:23

    Article  CAS  Google Scholar 

  88. Nagai H, Noguchi T, Takeda K, Ichijo H (2007) J Biochem Mol Biol 40:1

    Article  CAS  Google Scholar 

  89. Ko YG, Kim EY, Kim T, Park H, Park HS, Choi EJ, Kim S (2001) J Biol Chem 276:6030

    Article  CAS  Google Scholar 

  90. Martin DE, Hall MN (2005) Curr Opin Cell Biol 17:158

    Article  CAS  Google Scholar 

  91. Anthony JC, Anthony TG, Kimball SR, Jefferson LS (2001) J Nutr 131:856

    Google Scholar 

  92. Bonfils G, Jaquenoud M, Bontron S, Ostrowicz C, Ungermann C, De Virgilio C (2012) Mol Cell 46:105

    Article  CAS  Google Scholar 

  93. Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH, Kim S (2012) Cell 149:410

    Article  CAS  Google Scholar 

  94. Jewell JL, Russell RC, Guan KL (2013) Nat Rev Mol Cell Biol 14:133

    Article  CAS  Google Scholar 

  95. Sancak Y, Sabatini DM (2009) Biochem Soc Trans 37:289

    Article  CAS  Google Scholar 

  96. Collis SJ, DeWeese TL, Jeggo PA, Parker AR (2005) Oncogene 24:949

    Article  CAS  Google Scholar 

  97. Wakasugi K, Slike BM, Hood J, Otani A, Ewalt KL, Friedlander M, Cheresh DA, Schimmel P (2002) Proc Natl Acad Sci USA 99:173

    Article  CAS  Google Scholar 

  98. Yang XL, Skene RJ, McRee DE, Schimmel P (2002) Proc Natl Acad Sci USA 99:15369

    Article  CAS  Google Scholar 

  99. Sajish M, Zhou Q, Kishi S, Valdez DM Jr, Kapoor M, Guo M, Lee S, Kim S, Yang XL, Schimmel P (2012) Nat Chem Biol 8:547

    Article  CAS  Google Scholar 

  100. Tzima E, Reader JS, Irani-Tehrani M, Ewalt KL, Schwartz MA, Schimmel P (2005) J Biol Chem 280:2405

    Article  CAS  Google Scholar 

  101. Dejana E, Orsenigo F, Lampugnani MG (2008) J Cell Sci 121:2115

    Article  CAS  Google Scholar 

  102. Guelte LA, Gavard DJ (2011) J Biol Cell 103:593

    Article  CAS  Google Scholar 

  103. London NR, Whitehead KJ, Li DY (2009) Angiogenesis 12:149

    Article  CAS  Google Scholar 

  104. Vestweber D, Winderlich M, Cagna G, Nottebaum AF (2009) Trends Cell Biol 19:8

    Article  CAS  Google Scholar 

  105. Fox PL, Mazumder B, Ehrenwald E, Mukhopadhyay CK (2000) Free Radic Biol Med 28:1735

    Article  CAS  Google Scholar 

  106. Park MC, Kang T, Jin D, Han JM, Kim SB, Park YJ, Cho K, Park YW, Guo M, He W, Yang XL, Schimmel P, Kim S (2012) Proc Natl Acad Sci USA 109:640

    Article  Google Scholar 

  107. Brieher WM, Yap AS (2013) Curr Opin Cell Biol 25:39

    Article  CAS  Google Scholar 

  108. Akins MR, Benson DL, Greer CA (2007) J Comp Neurol 501:483

    Article  CAS  Google Scholar 

  109. Picard D (2002) Cell Mol Life Sci 59:1640

    Article  CAS  Google Scholar 

  110. Pearl LH, Prodromou C (2001) Adv Protein Chem 59:157

    Article  CAS  Google Scholar 

  111. Kang J, Kim T, Ko YG, Rho SB, Park SG, Kim MJ, Kwon HJ, Kim S (2000) J Biol Chem 275:31682

    Article  CAS  Google Scholar 

  112. Pearl LH, Prodromou C (2000) Curr Opin Struct Biol 10:46

    Article  CAS  Google Scholar 

  113. Pearl LH, Prodromou C (2006) Annu Rev Biochem 75:271

    Article  CAS  Google Scholar 

  114. Jackson SE (2013) Top Curr Chem 328:155

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Medicinal Bioconvergence Research Center, Graduate School of Convergence Science and Technology, College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea

    Jong Hyun Kim & Sunghoon Kim

  2. Department of Integrated OMICS for Biomedical Science, College of Pharmacy, Yonsei University, Seoul, 120-749, South Korea

    Jung Min Han

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  1. Jong Hyun Kim
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Correspondence to Jung Min Han .

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  1. Department of Molecular Medicine and Biopharmaceutical Sciences, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Korea, Republic of (South Korea)

    Sunghoon Kim

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Kim, J.H., Han, J.M., Kim, S. (2013). Protein–Protein Interactions and Multi-component Complexes of Aminoacyl-tRNA Synthetases. In: Kim, S. (eds) Aminoacyl-tRNA Synthetases in Biology and Medicine. Topics in Current Chemistry, vol 344. Springer, Dordrecht. https://doi.org/10.1007/128_2013_479

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