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C-H Activation pp 35–56Cite as

Mechanistic Considerations in the Development and Use of Azine, Diazine and Azole N-Oxides in Palladium-Catalyzed Direct Arylation

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Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 292))

Abstract

Azines, diazines or thiazole N-oxides are highly reactive substrates in palladium-catalyzed direct arylation reaction. For these reactions, the results are inconsistent with an SEAr reaction pathway and may best fit with a concerted metalation-deprotonation-like (CMD) mechanism.

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Acknowledgments

NSERC, the Research Corporation, the Sloan Foundation, the ACS (PRF AC), Merck Frosst, Merck Inc., Amgen, Eli Lilly, Astra Zeneca, and Boehringer Ingelheim are thanked for financial support of this and our other research programs.

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Authors and Affiliations

  1. Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON, Canada, K1N 6N5

    Keith Fagnou

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  1. Keith Fagnou
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Correspondence to Keith Fagnou .

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Editors and Affiliations

  1. Scripps Research Institute, N.Torrey Pines Rd. 10550, La Jolla, 92037, USA

    Jin-Quan Yu

  2. College of Chemistry, Peking University, Chengfu Road 202, Beijing, 100871, China, People's Republic

    Zhangjie Shi

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Fagnou, K. (2009). Mechanistic Considerations in the Development and Use of Azine, Diazine and Azole N-Oxides in Palladium-Catalyzed Direct Arylation. In: Yu, JQ., Shi, Z. (eds) C-H Activation. Topics in Current Chemistry, vol 292. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2009_14

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