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Fluorinated Anthracyclines

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Book cover Anthracycline Chemistry and Biology I

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 282))

Abstract

The introduction of fluorine into biologically active molecules today represents one of the classicapproaches used in medicinal chemistry in the search for both increased potency and a more favorablemetabolic pathway.

This chapter aims to offer an updated overview of the efforts made by several research groups in thefield of fluorinated anthracyclines. We also give, along with the structures, brief descriptions of thesyntheses and current status of development.

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Authors and Affiliations

  1. R&D, Dept. of Chemistry – Sigma-Tau, via Pontina Km 30, 400, I-00040, Pomezia (Rome), Italy

    Giuseppe Giannini & Domenico Alloatti

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  1. Giuseppe Giannini
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  2. Domenico Alloatti
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Correspondence to Giuseppe Giannini .

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Karsten Krohn

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Giannini, G., Alloatti, D. (2007). Fluorinated Anthracyclines. In: Krohn, K. (eds) Anthracycline Chemistry and Biology I. Topics in Current Chemistry, vol 282. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2007_9

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