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Biosynthetic Anthracycline Variants

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Book cover Anthracycline Chemistry and Biology I

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 282))

Abstract

In addition to synthetic and semisynthetic methods, new anthracycline structures have been generatedby biosynthetic methods: genetic engineering of Streptomyces productionstrains, bioconversion and chemoenzymatic synthesis. In this review, we discuss the set of moleculespotentially producible by biosynthetic methods and which structures have so far been realized. Biosyntheticvariation in the anthracycline molecule manifests itself either as structure changes in the tetracyclicaglycone, or as variation in glycosylation. Understanding the biosynthetic sequence and knowledgeof the substrate specificities of the enzymes participating in it enable rational generation of newanthracycline diversity. Future possibilities include protein engineering of the biosynthetic enzymesto improve the production of new structural combinations.

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Authors and Affiliations

  1. Department of Biochemistry and Food Chemistry, University of Turku, 20014, Turku, Finland

    Jarmo Niemi & Pekka Mäntsälä

  2. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden

    Mikko Metsä-Ketelä & Gunter Schneider

Authors
  1. Jarmo Niemi
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  2. Mikko Metsä-Ketelä
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  3. Gunter Schneider
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  4. Pekka Mäntsälä
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Corresponding author

Correspondence to Jarmo Niemi .

Editor information

Karsten Krohn

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© 2008 Springer-Verlag Berlin Heidelberg

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Niemi, J., Metsä-Ketelä, M., Schneider, G., Mäntsälä, P. (2008). Biosynthetic Anthracycline Variants. In: Krohn, K. (eds) Anthracycline Chemistry and Biology I. Topics in Current Chemistry, vol 282. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2007_13

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