Chapter

Functional Imaging and Modeling of the Heart

Volume 3504 of the series Lecture Notes in Computer Science pp 162-171

Virtual Ventricular Wall: Effects of Pathophysiology and Pharmacology on Transmural Propagation

  • Oleg V. AslanidiAffiliated withSchool of Biomedical Sciences, University of Leeds
  • , Jennifer L. LambertAffiliated withSchool of Medicine, University of Leeds
  • , Neil T. SrinivasanAffiliated withSchool of Medicine, University of Leeds
  • , Arun V. HoldenAffiliated withSchool of Biomedical Sciences, University of Leeds

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Abstract

Effects of pathophysiological conditions and pharmacological intervention on transmural propagation are computed for the virtual ventricular wall. ST depression during sub-endocardial ischaemia and unidirectional functional block in the vulnerable window during Class III drug action are explained by changes induced in the transmural dispersion of action potential duration.