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TRPs in the Brain

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Reviews of Physiology, Biochemistry and Pharmacology, Vol. 163

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 163))

Abstract

The Transient receptor potential (TRP) family of cation channels is a large protein family, which is mainly structurally uniform. Proteins consist typically of six transmembrane domains and mostly four subunits are necessary to form a functional channel. Apart from this, TRP channels display a wide variety of activation mechanisms (ligand binding, G-protein coupled receptor dependent, physical stimuli such as temperature, pressure, etc.) and ion selectivity profiles (from highly Ca2+ selective to non-selective for cations). They have been described now in almost every tissue of the body, including peripheral and central neurons. Especially in the sensory nervous system the role of several TRP channels is already described on a detailed level. This review summarizes data that is currently available on their role in the central nervous system. TRP channels are involved in neurogenesis and brain development, synaptic transmission and they play a key role in the development of several neurological diseases.

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Acknowledgments

The authors are supported by the FWO Vlaanderen and the Bijzonder Onderzoeksfonds of the KU Leuven. We would like to thank all members of the Laboratory of Ion Channel Research, KU Leuven, for stimulating discussions.

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Authors and Affiliations

  1. Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine (CMM), KU Leuven, Herestraat 49 (bus 802), BE-3000, Leuven, Belgium

    Rudi Vennekens, Aurelie Menigoz & Bernd Nilius

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  1. Rudi Vennekens
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  2. Aurelie Menigoz
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  3. Bernd Nilius
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Correspondence to Rudi Vennekens .

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Editors and Affiliations

  1. Lab. Fysiologie, Katholieke Universiteit Leuven, Herestraat 49, Leuven, 3000, Belgium

    Bernd Nilius

  2. School of Medicine, Deptartment of Neurobiology, University of Pittsburgh, Fifth Avenue 3501, Pittsburgh, 15261, Pennsylvania, USA

    Susan G. Amara

  3. Medizinische Fakultät, Walther-Straub-Institut für Pharmakologi, Ludwig-Maximilians-Universität München, Goethestr. 33, München, 80336, Germany

    Thomas Gudermann

  4. Abt. Neurobiologie, MPI für Biophysikalische Chemie, Am Faßberg 11, Göttingen, 37077, Germany

    Reinhard Jahn

  5. Inst. Zytobiologie und, Zytopathologie, Universität Marburg, Robert-Koch-Str. 5, Marburg, 35033, Germany

    Roland Lill

  6. , Abteilung II, Max-Planck-Institut für Herz- und Lungen, Ludwigstr. 43, Bad Nauheim, 61231, Germany

    Stefan Offermanns

  7. School of Biosciences, Cardiff University, Museum Ave., Cardiff, CF10 3US, United Kingdom

    Ole H. Petersen

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Vennekens, R., Menigoz, A., Nilius, B. (2012). TRPs in the Brain. In: Nilius, B., et al. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 163. Reviews of Physiology, Biochemistry and Pharmacology, vol 163. Springer, Berlin, Heidelberg. https://doi.org/10.1007/112_2012_8

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