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Part of the series Advances in Biochemical Engineering/Biotechnology pp 1-41

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Network Metamodeling: Effect of Correlation Metric Choice on Phylogenomic and Transcriptomic Network Topology

  • Deborah A. WeighillAffiliated withFaculty of AgriSciences, Institute for Wine Biotechnology, Stellenbosch UniversityThe Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, KnoxvilleBiosciences Division, Oak Ridge National Laboratory
  • , Daniel JacobsonAffiliated withFaculty of AgriSciences, Institute for Wine Biotechnology, Stellenbosch UniversityThe Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, KnoxvilleBiosciences Division, Oak Ridge National Laboratory Email author 

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Abstract

We explore the use of a network meta-modeling approach to compare the effects of similarity metrics used to construct biological networks on the topology of the resulting networks. This work reviews various similarity metrics for the construction of networks and various topology measures for the characterization of resulting network topology, demonstrating the use of these metrics in the construction and comparison of phylogenomic and transcriptomic networks.

Keywords

Network comparison Network topology Similarity metrics