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Genomics and Systems Biology of Mammalian Cell Culture pp 251–284Cite as

Genetic Aspects of Cell Line Development from a Synthetic Biology Perspective

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Part of the book series: Advances in Biochemical Engineering Biotechnology ((ABE,volume 127))

Abstract

Animal cells can be regarded as factories for the production of relevant proteins. The advances described in this chapter towards the development of cell lines with higher productivity capacities, certain metabolic and proliferation properties, reduced apoptosis and other features must be regarded in an integrative perspective. The systematic application of systems biology approaches in combination with a synthetic arsenal for targeted modification of endogenous networks are proposed to lead towards the achievement of a predictable and technologically advanced cell system with high biotechnological impact.

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    L. Botezatu, S. Sievers, L. Gama-Norton, R. Schucht, H. Hauser & D. Wirth

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    Wei Shou Hu

  2. , Institut für Bioprozess- und Biosystemte, Technische Universität Hamburg-Harburg, Denickestr. 15, Hamburg, 21073, Germany

    An-Ping Zeng

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Botezatu, L., Sievers, S., Gama-Norton, L., Schucht, R., Hauser, H., Wirth, D. (2011). Genetic Aspects of Cell Line Development from a Synthetic Biology Perspective. In: Hu, W., Zeng, AP. (eds) Genomics and Systems Biology of Mammalian Cell Culture. Advances in Biochemical Engineering Biotechnology, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2011_117

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