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Nano/Micro Biotechnology pp 251–265Cite as

Development of Fundamental Technologies for Micro Bioreactors

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Part of the book series: Advances in Biochemical Engineering / Biotechnology ((ABE,volume 119))

Abstract

This chapter reviews the development of fundamental technologies required for microchip-based bioreactors utilizing living mammalian cells and pressure driven flow. The most important factor in the bioreactor is the cell culture. For proper cell culturing, continuous medium supply from a microfluidic channel and appropriate modification of the channel surface to accommodate cell attachment is required. Moreover, the medium flow rate should be chosen carefully, because shear stress affects cell activity. The techniques presented here could be applied to the development of micro bioreactors such as microlivers, pigment production by plant cells, and artificial insemination.

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Acknowledgements

We thank Drs. Björn Renberg and Kae Sato for critical reading of the manuscript.

Author information

Authors and Affiliations

  1. Department of Applied Biological Chemistry, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan

    Kiichi Sato

  2. Center for NanoBio Integration, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

    Kiichi Sato & Takehiko Kitamori

  3. PRESTO, Japan Science and Technology Agency (JST), Sambancho, Chiyoda-ku, Tokyo, 102-0075, Japan

    Kiichi Sato

  4. Department of Applied Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

    Takehiko Kitamori

  5. Micro Chemistry Group, Kanagawa Academy of Science and Technology, Sakado, Takatsu-ku, Kawasaki, Kanagawa, 213-0012, Japan

    Takehiko Kitamori

Authors
  1. Kiichi Sato
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  2. Takehiko Kitamori
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Corresponding author

Correspondence to Takehiko Kitamori .

Editor information

Editors and Affiliations

  1. Saitama Industrial Technology Center, Kamiaoki 3-12-18, Kawaguchi-shi, Saitama, 333-0844, Japan

    Isao Endo

  2. School of Engineering, Dept. Bioengineering, University of Tokyo, Hongo 7-3-1, Tokyo, 113-8656, Japan

    Teruyuki Nagamune

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© 2009 Springer-Verlag Berlin Heidelberg

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Sato, K., Kitamori, T. (2009). Development of Fundamental Technologies for Micro Bioreactors. In: Endo, I., Nagamune, T. (eds) Nano/Micro Biotechnology. Advances in Biochemical Engineering / Biotechnology, vol 119. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2008_43

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