Abstract
Estrogens play an important role in mammalian reproductive cycles and a disturbance of this cycle can cause adverse effects like carcinogenicity. A mechanistic modeling approach is helpful in attempting to unravel the entanglement of genomic, non-genomic, and feedback signals involved in endocrine signaling. To make more balanced decisions on possible human health risks put forth by endocrine active compounds (e.g., estrogens and estrogen-like agents), a multidisciplinary approach is necessary. Besides traditional epidemiological studies, accumulation of mechanistic data is essential for all classes of agents. Combining all available information is a positive move towards a more complete risk assessment process.
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© 2002 Springer-Verlag Berlin Heidelberg
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Willems, B.A.T., Portier, C.J., Lucier, G.W. (2002). Mechanism-Based Carcinogenic Risk Assessment of Estrogens and Estrogen-Like Compounds. In: Metzler, M. (eds) Endocrine Disruptors – Part II . The Handbook of Environmental Chemistry, vol 3M. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10833691_4
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DOI: https://doi.org/10.1007/10833691_4
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